MicroRNA-independent roles of the RNase III enzymes Drosha and Dicer
The ribonuclease III enzymes Drosha and Dicer are renowned for their central roles in the biogenesis of microRNAs (miRNAs). For many years, this has overshadowed the true versatility and importance of these enzymes in the processing of other RNA substrates. For example, Drosha also recognizes and cl...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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The Royal Society
2013-01-01
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| Series: | Open Biology |
| Subjects: | |
| Online Access: | https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.130144 |
| _version_ | 1818313764724801536 |
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| author | Timothy M. Johanson Andrew M. Lew Mark M. W. Chong |
| author_facet | Timothy M. Johanson Andrew M. Lew Mark M. W. Chong |
| author_sort | Timothy M. Johanson |
| collection | DOAJ |
| description | The ribonuclease III enzymes Drosha and Dicer are renowned for their central roles in the biogenesis of microRNAs (miRNAs). For many years, this has overshadowed the true versatility and importance of these enzymes in the processing of other RNA substrates. For example, Drosha also recognizes and cleaves messenger RNAs (mRNAs), and potentially ribosomal RNA. The cleavage of mRNAs occurs via recognition of secondary stem-loop structures similar to miRNA precursors, and is an important mechanism of repressing gene expression, particularly in progenitor/stem cell populations. On the other hand, Dicer also has critical roles in genome regulation and surveillance. These include the production of endogenous small interfering RNAs from many sources, and the degradation of potentially harmful short interspersed element and viral RNAs. These findings have sparked a renewed interest in these enzymes, and their diverse functions in biology. |
| first_indexed | 2024-12-13T08:38:56Z |
| format | Article |
| id | doaj.art-c82ef0a58456404ead4ad306d5653d99 |
| institution | Directory Open Access Journal |
| issn | 2046-2441 |
| language | English |
| last_indexed | 2024-12-13T08:38:56Z |
| publishDate | 2013-01-01 |
| publisher | The Royal Society |
| record_format | Article |
| series | Open Biology |
| spelling | doaj.art-c82ef0a58456404ead4ad306d5653d992022-12-21T23:53:35ZengThe Royal SocietyOpen Biology2046-24412013-01-0131010.1098/rsob.130144130144MicroRNA-independent roles of the RNase III enzymes Drosha and DicerTimothy M. JohansonAndrew M. LewMark M. W. ChongThe ribonuclease III enzymes Drosha and Dicer are renowned for their central roles in the biogenesis of microRNAs (miRNAs). For many years, this has overshadowed the true versatility and importance of these enzymes in the processing of other RNA substrates. For example, Drosha also recognizes and cleaves messenger RNAs (mRNAs), and potentially ribosomal RNA. The cleavage of mRNAs occurs via recognition of secondary stem-loop structures similar to miRNA precursors, and is an important mechanism of repressing gene expression, particularly in progenitor/stem cell populations. On the other hand, Dicer also has critical roles in genome regulation and surveillance. These include the production of endogenous small interfering RNAs from many sources, and the degradation of potentially harmful short interspersed element and viral RNAs. These findings have sparked a renewed interest in these enzymes, and their diverse functions in biology.https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.130144rnase iii enzymesdroshadicermicrornarna processing |
| spellingShingle | Timothy M. Johanson Andrew M. Lew Mark M. W. Chong MicroRNA-independent roles of the RNase III enzymes Drosha and Dicer Open Biology rnase iii enzymes drosha dicer microrna rna processing |
| title | MicroRNA-independent roles of the RNase III enzymes Drosha and Dicer |
| title_full | MicroRNA-independent roles of the RNase III enzymes Drosha and Dicer |
| title_fullStr | MicroRNA-independent roles of the RNase III enzymes Drosha and Dicer |
| title_full_unstemmed | MicroRNA-independent roles of the RNase III enzymes Drosha and Dicer |
| title_short | MicroRNA-independent roles of the RNase III enzymes Drosha and Dicer |
| title_sort | microrna independent roles of the rnase iii enzymes drosha and dicer |
| topic | rnase iii enzymes drosha dicer microrna rna processing |
| url | https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.130144 |
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