Deficient DNA base-excision repair in the forebrain leads to a sex-specific anxiety-like phenotype in mice

Deficient DNA base-excision repair in the forebrain leads to a sex-specific anxiety-like phenotype in mice

Abstract Background Neuropsychiatric disorders, such as schizophrenia (SZ) and autism spectrum disorder (ASD), are common, multi-factorial and multi-symptomatic disorders. Ample evidence implicates oxidative stress, deficient repair of oxidative DNA lesions and DNA damage in the development of these...

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Bibliographic Details
Main Authors: Flavia S. Mueller, René Amport, Tina Notter, Sina M. Schalbetter, Han-Yu Lin, Zuzana Garajova, Parisa Amini, Ulrike Weber-Stadlbauer, Enni Markkanen
Format: Article
Language:English
Published: BMC 2022-07-01
Series:BMC Biology
Subjects:
Neuronal DNA damage
Anxiety
GABA
XRCC1
DNA repair
Online Access:https://doi.org/10.1186/s12915-022-01377-1

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