CLCA1 Regulates Airway Mucus Production and Ion Secretion Through TMEM16A

CLCA1 Regulates Airway Mucus Production and Ion Secretion Through TMEM16A

TMEM16A, a Ca<sup>2+</sup>-activated chloride channel (CaCC), and its regulator, CLCA1, are associated with inflammatory airway disease and goblet cell metaplasia. CLCA1 is a secreted protein with protease activity that was demonstrated to enhance membrane expression of TMEM16A. Expressi...

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Bibliographic Details
Main Authors: Raquel Centeio, Jiraporn Ousingsawat, Rainer Schreiber, Karl Kunzelmann
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:International Journal of Molecular Sciences
Subjects:
CLCA1
TMEM16A
anoctamin 1
airway epithelium
mucus
MUC5AC
Online Access:https://www.mdpi.com/1422-0067/22/10/5133

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