Discovery of Novel Chemical Series of OXA-48 β-Lactamase Inhibitors by High-Throughput Screening

Discovery of Novel Chemical Series of OXA-48 β-Lactamase Inhibitors by High-Throughput Screening

The major cause of bacterial resistance to β-lactams is the production of hydrolytic β-lactamase enzymes. Nowadays, the combination of β-lactam antibiotics with β-lactamase inhibitors (BLIs) is the main strategy for overcoming such issues. Nevertheless, particularly challenging β-lactamases, such as...

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Bibliographic Details
Main Authors: Barbara Garofalo, Federica Prati, Rosa Buonfiglio, Isabella Coletta, Noemi D’Atanasio, Angela Molteni, Daniele Carettoni, Valeria Wanke, Giorgio Pochetti, Roberta Montanari, Davide Capelli, Claudio Milanese, Francesco Paolo Di Giorgio, Rosella Ombrato
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Pharmaceuticals
Subjects:
OXA-48
β-lactamase inhibitor
bacterial resistance
HTS
Online Access:https://www.mdpi.com/1424-8247/14/7/612

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