Usefulness of absorption techniques in doubtful cases of incompatibility Rh maternal fetal: a case report
INTRODUCTION This case report traces the diagnostic and therapeutic process of the Immuno-Transfusion Service in a case of fetal anaemia characterized by various inconsistencies between clinical and laboratory data. The paper describes an alternative technique implemented with the aim of reso...
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Format: | Article |
Language: | English |
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Università degli Studi di Torino
2023-06-01
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Series: | Journal of Biomedical Practitioners |
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Online Access: | https://ojs.unito.it/index.php/jbp/article/view/7771 |
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author | Eleonora Donno Jessica Di Monte Manuela Di Mascio Tiziana Orsini Annalisa Di Valerio Luisa Pinti Paola Massaro Seila Scardapane Francesca Fusilli Franco Salvatore Amalia Procida Antonio Esposito |
author_facet | Eleonora Donno Jessica Di Monte Manuela Di Mascio Tiziana Orsini Annalisa Di Valerio Luisa Pinti Paola Massaro Seila Scardapane Francesca Fusilli Franco Salvatore Amalia Procida Antonio Esposito |
author_sort | Eleonora Donno |
collection | DOAJ |
description |
INTRODUCTION
This case report traces the diagnostic and therapeutic process of the Immuno-Transfusion Service in a case of fetal anaemia characterized by various inconsistencies between clinical and laboratory data.
The paper describes an alternative technique implemented with the aim of resolving incompatibilities between positive IAT and negative DAT.
In addition, the algorithm necessary to reach a diagnosis in a transfusion medicine laboratory is traced, namely, the performance of first- and second-level immuno-haematological tests, the evaluation of fetal clinical signs, and the preparation of blood components necessary for intrauterine transfusion.
CASE PRESENTATION
The case involves a pregnant woman who comes to the Immuno-Transfusion Service following a positive Indirect Antiglobulin Test and fetal anaemia.
The main questions relate not only the presence of immunization in the woman, which should have been avoided by immunoprophylaxis (being group 0 Rh negative), but also the stability of the antibody titer (or level) throughout the pregnancy, fetal recovery after TIU, and the presence of a negative Direct Antiglobulin Test.
CONCLUSIONS
Questions that were completely resolved at caesarean section with the discovery of a giant chorioangioma that, by sequestering fetal red blood cells, caused anaemia and the confirmation of a rare blood phenotype of the father that caused the woman's immunization.
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first_indexed | 2024-03-13T03:14:23Z |
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id | doaj.art-c83245f1007542fa87c8241da9a72ea1 |
institution | Directory Open Access Journal |
issn | 2532-7925 |
language | English |
last_indexed | 2024-03-13T03:14:23Z |
publishDate | 2023-06-01 |
publisher | Università degli Studi di Torino |
record_format | Article |
series | Journal of Biomedical Practitioners |
spelling | doaj.art-c83245f1007542fa87c8241da9a72ea12023-06-26T06:50:02ZengUniversità degli Studi di TorinoJournal of Biomedical Practitioners2532-79252023-06-017110.13135/2532-7925/7771Usefulness of absorption techniques in doubtful cases of incompatibility Rh maternal fetal: a case reportEleonora Donno0Jessica Di Monte1Manuela Di Mascio2Tiziana Orsini3Annalisa Di Valerio4Luisa Pinti5Paola Massaro6Seila Scardapane7Francesca Fusilli8Franco Salvatore9Amalia Procida10Antonio Esposito11Università degli studi “Gabriele d’Annunzio”, Chieti - ItaServizio di Immunoematologia e Medicina Trasfusionale, Ospedale Clinicizzato “SS. Annunziata”, Chieti - ItaServizio di Immunoematologia e Medicina Trasfusionale, Ospedale Clinicizzato “SS. Annunziata”, Chieti - ItaServizio di Immunoematologia e Medicina Trasfusionale, Ospedale Clinicizzato “SS. Annunziata”, Chieti - ItaServizio di Immunoematologia e Medicina Trasfusionale, Ospedale Clinicizzato “SS. Annunziata”, Chieti - ItaServizio di Immunoematologia e Medicina Trasfusionale, Ospedale Clinicizzato “SS. Annunziata”, Chieti - ItaServizio di Immunoematologia e Medicina Trasfusionale, Ospedale Clinicizzato “SS. Annunziata”, Chieti - ItaServizio di Immunoematologia e Medicina Trasfusionale, Ospedale Clinicizzato “SS. Annunziata”, Chieti - ItaServizio di Immunoematologia e Medicina Trasfusionale, Ospedale Clinicizzato “SS. Annunziata”, Chieti - ItaServizio di Immunoematologia e Medicina Trasfusionale, Ospedale Clinicizzato “SS. Annunziata”, Chieti - ItaServizio di Immunoematologia e Medicina Trasfusionale, Ospedale Clinicizzato “SS. Annunziata”, Chieti - ItaUniversità degli studi “Gabriele d’Annunzio”, Chieti - Ita INTRODUCTION This case report traces the diagnostic and therapeutic process of the Immuno-Transfusion Service in a case of fetal anaemia characterized by various inconsistencies between clinical and laboratory data. The paper describes an alternative technique implemented with the aim of resolving incompatibilities between positive IAT and negative DAT. In addition, the algorithm necessary to reach a diagnosis in a transfusion medicine laboratory is traced, namely, the performance of first- and second-level immuno-haematological tests, the evaluation of fetal clinical signs, and the preparation of blood components necessary for intrauterine transfusion. CASE PRESENTATION The case involves a pregnant woman who comes to the Immuno-Transfusion Service following a positive Indirect Antiglobulin Test and fetal anaemia. The main questions relate not only the presence of immunization in the woman, which should have been avoided by immunoprophylaxis (being group 0 Rh negative), but also the stability of the antibody titer (or level) throughout the pregnancy, fetal recovery after TIU, and the presence of a negative Direct Antiglobulin Test. CONCLUSIONS Questions that were completely resolved at caesarean section with the discovery of a giant chorioangioma that, by sequestering fetal red blood cells, caused anaemia and the confirmation of a rare blood phenotype of the father that caused the woman's immunization. https://ojs.unito.it/index.php/jbp/article/view/7771Indirect antiglobulin test (IAT)haemolytic disease of the newbornRh alloimmunizationfetal anaemiagiant chorioangioma |
spellingShingle | Eleonora Donno Jessica Di Monte Manuela Di Mascio Tiziana Orsini Annalisa Di Valerio Luisa Pinti Paola Massaro Seila Scardapane Francesca Fusilli Franco Salvatore Amalia Procida Antonio Esposito Usefulness of absorption techniques in doubtful cases of incompatibility Rh maternal fetal: a case report Journal of Biomedical Practitioners Indirect antiglobulin test (IAT) haemolytic disease of the newborn Rh alloimmunization fetal anaemia giant chorioangioma |
title | Usefulness of absorption techniques in doubtful cases of incompatibility Rh maternal fetal: a case report |
title_full | Usefulness of absorption techniques in doubtful cases of incompatibility Rh maternal fetal: a case report |
title_fullStr | Usefulness of absorption techniques in doubtful cases of incompatibility Rh maternal fetal: a case report |
title_full_unstemmed | Usefulness of absorption techniques in doubtful cases of incompatibility Rh maternal fetal: a case report |
title_short | Usefulness of absorption techniques in doubtful cases of incompatibility Rh maternal fetal: a case report |
title_sort | usefulness of absorption techniques in doubtful cases of incompatibility rh maternal fetal a case report |
topic | Indirect antiglobulin test (IAT) haemolytic disease of the newborn Rh alloimmunization fetal anaemia giant chorioangioma |
url | https://ojs.unito.it/index.php/jbp/article/view/7771 |
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