Retinoic acid delays initial photoreceptor differentiation and results in a highly structured mature retinal organoid

Retinoic acid delays initial photoreceptor differentiation and results in a highly structured mature retinal organoid

Abstract Background Human-induced pluripotent stem cell-derived retinal organoids are a valuable tool for disease modelling and therapeutic development. Many efforts have been made over the last decade to optimise protocols for the generation of organoids that correctly mimic the human retina. Most...

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Main Authors: Carla Sanjurjo-Soriano, Nejla Erkilic, Krishna Damodar, Hassan Boukhaddaoui, Michalitsa Diakatou, Marcela Garita-Hernandez, Daria Mamaeva, Gregor Dubois, Zhour Jazouli, Carla Jimenez-Medina, Olivier Goureau, Isabelle Meunier, Vasiliki Kalatzis
Format: Article
Language:English
Published: BMC 2022-09-01
Series:Stem Cell Research & Therapy
Subjects:
Induced pluripotent stem cells
Retinal organoids
Retinoic acid
Photoreceptors
Rods
Cones
Online Access:https://doi.org/10.1186/s13287-022-03146-x

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