Peroxisome proliferator-activated receptors, farnesoid X receptor, and dual modulating drugs in hypertension

Peroxisome proliferator-activated receptors, farnesoid X receptor, and dual modulating drugs in hypertension

Hypertension characterized by an elevated blood pressure is a cardiovascular disease that afflicts greater than one in every three adults worldwide. Nuclear receptors are large superfamily of DNA-binding transcription factors that target genes to regulate metabolic and cardiovascular function. Drugs...

Full description

Bibliographic Details
Main Author:	John D. Imig
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-06-01
Series:	Frontiers in Physiology
Subjects:	blood pressure proliferator-activated receptors farnesoid X receptor soluble epoxide hydrolase diabetes
Online Access:	https://www.frontiersin.org/articles/10.3389/fphys.2023.1186477/full

Similar Items

Dual soluble epoxide hydrolase inhibitor – farnesoid X receptor agonist interventional treatment attenuates renal inflammation and fibrosis
by: Md. Abdul Hye Khan, et al.
Published: (2024-01-01)

Natural Products Targeting Liver X Receptors or Farnesoid X Receptor
by: Jianglian She, et al.
Published: (2022-01-01)

Editorial: Nuclear receptors in hemodynamics and blood pressure control
by: John D. Imig, et al.
Published: (2023-09-01)

Multi-Target Approaches in Metabolic Syndrome
by: Felix F. Lillich, et al.
Published: (2021-03-01)

Structural basis of the farnesoid X receptor/retinoid X receptor heterodimer on inverted repeat DNA
by: Longying Jiang, et al.
Published: (2023-01-01)

Stimulation of the farnesoid X receptor promotes M2 macrophage polarization
by: Thiranut Jaroonwitchawan, et al.
Published: (2023-01-01)

Mangrove Tirucallane- and Apotirucallane-Type Triterpenoids: Structure Diversity of the C-17 Side-Chain and Natural Agonists of Human Farnesoid/Pregnane–X–Receptor
by: Zhong-Ping Jiang, et al.
Published: (2018-12-01)

Farnesoid X Receptor, Bile Acid Metabolism, and Gut Microbiota
by: Hideki Mori, et al.
Published: (2022-07-01)

TO901317 regulating apolipoprotein M expression mediates via the farnesoid X receptor pathway in Caco-2 cells
by: Berggren-Söderlund Maria, et al.
Published: (2011-11-01)

Upregulation of microRNA-23b-3p induced by farnesoid X receptor regulates the proliferation and apoptosis of osteosarcoma cells
by: Bin Wu, et al.
Published: (2019-11-01)

Farnesoid X Receptor Expression in Microscopic Colitis: A Potential Role in Disease Etiopathogenesis
by: Joana Torres, et al.
Published: (2017-10-01)

The Farnesoid X Receptor as a Master Regulator of Hepatotoxicity
by: Magdalena Rausch, et al.
Published: (2022-11-01)

Expanding the Library of 1,2,4-Oxadiazole Derivatives: Discovery of New Farnesoid X Receptor (FXR) Antagonists/Pregnane X Receptor (PXR) Agonists
by: Claudia Finamore, et al.
Published: (2023-03-01)

The regulation of tissue-specific farnesoid X receptor on genes and diseases involved in bile acid homeostasis
by: Dong Xiang, et al.
Published: (2023-12-01)

Xanthohumol improves cognition in farnesoid X receptor-deficient mice on a high-fat diet
by: Payel Kundu, et al.
Published: (2022-11-01)

Role of farnesoid X receptor and bile acids in alcoholic liver disease
by: Sharon Manley, et al.
Published: (2015-03-01)

Restraint stress promotes nonalcoholic steatohepatitis by regulating the farnesoid X receptor/NLRP3 signaling pathway
by: Yang Fan, et al.
Published: (2023-11-01)

Farnesoid X receptor knockout protects brain against ischemic injury through reducing neuronal apoptosis in mice
by: Hui-Min Shan, et al.
Published: (2020-05-01)

Bile Acid Nuclear Receptor Farnesoid X Receptor: Therapeutic Target for Nonalcoholic Fatty Liver Disease
by: Sun-Gi Kim, et al.
Published: (2016-12-01)

Saffron offers hepatoprotection via up-regulation of hepatic farnesoid-X-activated receptors in a rat model of acetaminophen-induced hepatotoxicity
by: Vahid Jamshidi, et al.
Published: (2021-11-01)

Bile Acids Elevated in Chronic Periaortitis Could Activate Farnesoid-X-Receptor to Suppress IL-6 Production by Macrophages
by: Shan Cao, et al.
Published: (2021-04-01)

Loss of Farnesoid X receptor (FXR) accelerates dysregulated glucose and renal injury in db/db mice
by: Yuxiang Qiu, et al.
Published: (2023-09-01)

Norcholic Acid Promotes Tumor Progression and Immune Escape by Regulating Farnesoid X Receptor in Hepatocellular Carcinoma
by: Yihang Gong, et al.
Published: (2021-11-01)

PRIMIS: design of a pivotal, randomized, phase 3 study evaluating the safety and efficacy of the nonsteroidal farnesoid X receptor agonist cilofexor in noncirrhotic patients with primary sclerosing cholangitis
by: Michael Trauner, et al.
Published: (2023-03-01)

Alpha-linolenic acid inhibits hepatocellular carcinoma cell growth through Farnesoid X receptor/β-catenin signaling pathway
by: Shu Feng, et al.
Published: (2022-08-01)

Gypenosides ameliorate high-fat diet-induced non-alcoholic steatohepatitis via farnesoid X receptor activation
by: Hongshan Li, et al.
Published: (2022-08-01)

Farnesoid X receptor regulates forkhead Box O3a activation in ethanol-induced autophagy and hepatotoxicity
by: Sharon Manley, et al.
Published: (2014-01-01)

Biliary cirrhosis-induced cardiac abnormality in rats: Interaction between Farnesoid-X-activated receptors and the cardiac uncoupling proteins 2 and 3
by: Gholamreza Bayat, et al.
Published: (2022-01-01)

Farnesoid X receptor, the bile acid sensing nuclear receptor, in liver regeneration
by: Guodong Li, et al.
Published: (2015-03-01)

Arbutin Alleviates the Liver Injury of α-Naphthylisothiocyanate-induced Cholestasis Through Farnesoid X Receptor Activation
by: Peijie Wu, et al.
Published: (2021-12-01)

Xanthohumol ameliorates Diet-Induced Liver Dysfunction via Farnesoid X Receptor-Dependent and Independent Signaling
by: Ines L. Paraiso, et al.
Published: (2021-04-01)

The Pathophysiology of Farnesoid X Receptor (FXR) in the GI Tract: Inflammation, Barrier Function and Innate Immunity
by: Kemp M. Anderson, et al.
Published: (2021-11-01)

Farnesoid-X receptor as a therapeutic target for inflammatory bowel disease and colorectal cancer
by: Mengjiao Zhou, et al.
Published: (2022-10-01)

Baicalin Protects Against 17α-Ethinylestradiol-Induced Cholestasis via the Sirtuin 1/Hepatic Nuclear Receptor-1α/Farnesoid X Receptor Pathway
by: Jinyu Yang, et al.
Published: (2020-02-01)

Taurocholic Acid and Glycocholic Acid Inhibit Inflammation and Activate Farnesoid X Receptor Expression in LPS-Stimulated Zebrafish and Macrophages
by: Xutao Ge, et al.
Published: (2023-02-01)

Regulation of Chromatin Accessibility by the Farnesoid X Receptor Is Essential for Circadian and Bile Acid Homeostasis In Vivo
by: Haider M. Hassan, et al.
Published: (2022-12-01)

INT-767—A Dual Farnesoid-X Receptor (FXR) and Takeda G Protein-Coupled Receptor-5 (TGR5) Agonist Improves Survival in Rats and Attenuates Intestinal Ischemia Reperfusion Injury
by: Emilio Canovai, et al.
Published: (2023-10-01)

The Status of Bile Acids and Farnesoid X Receptor in Brain and Liver of Rats with Thioacetamide-Induced Acute Liver Failure
by: Anna Maria Czarnecka, et al.
Published: (2020-10-01)

Farnesoid X receptor agonist tropifexor attenuates cholestasis in a randomised trial in patients with primary biliary cholangitis
by: Christoph Schramm, et al.
Published: (2022-11-01)

Role of farnesoid X receptor in establishment of ontogeny of phase-I drug metabolizing enzyme genes in mouse liver
by: Lai Peng, et al.
Published: (2016-09-01)