Cyclophosphamide treatment regulates the balance of functional/exhausted tumor-specific CD8+ T cells

Cyclophosphamide treatment regulates the balance of functional/exhausted tumor-specific CD8+ T cells

An important question is how chemotherapy may (re-)activate tumor-specific immunity. In this study, we provide a phenotypic, functional and genomic analysis of tumor-specific CD8+ T cells in tumor (P815)-bearing mice, treated or not with cyclophosphamide. Our data show that chemotherapy favors the d...

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Bibliographic Details
Main Authors: Aurélie Hanoteau, Coralie Henin, David Svec, Charlotte Bisilliat Donnet, Sébastien Denanglaire, Didier Colau, Pedro Romero, Oberdan Leo, Benoit Van den Eynde, Muriel Moser
Format: Article
Language:English
Published: Taylor & Francis Group 2017-08-01
Series:OncoImmunology
Subjects:
cd8+ t cells
cyclophosphamide
effector function
exhaustion
tumor-specific immunity
Online Access:http://dx.doi.org/10.1080/2162402X.2017.1318234

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