Chemical Compositions and Experimental and Computational Modeling of the Anticancer Effects of Cnidocyte Venoms of Jellyfish <i>Cassiopea andromeda</i> and <i>Catostylus mosaicus</i> on Human Adenocarcinoma A549 Cells
Nowadays, major attention is being paid to curing different types of cancers and is focused on natural resources, including oceans and marine environments. Jellyfish are marine animals with the ability to utilize their venom in order to both feed and defend. Prior studies have displayed the anticanc...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | Marine Drugs |
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| Online Access: | https://www.mdpi.com/1660-3397/21/3/168 |
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| author | Afshin Zare Alireza Afshar Arezoo Khoradmehr Neda Baghban Gholamhossein Mohebbi Alireza Barmak Adel Daneshi Afshar Bargahi Iraj Nabipour Sahar Almasi-Turk Alireza Arandian Mohammad Ismail Zibaii Hamid Latifi Amin Tamadon |
| author_facet | Afshin Zare Alireza Afshar Arezoo Khoradmehr Neda Baghban Gholamhossein Mohebbi Alireza Barmak Adel Daneshi Afshar Bargahi Iraj Nabipour Sahar Almasi-Turk Alireza Arandian Mohammad Ismail Zibaii Hamid Latifi Amin Tamadon |
| author_sort | Afshin Zare |
| collection | DOAJ |
| description | Nowadays, major attention is being paid to curing different types of cancers and is focused on natural resources, including oceans and marine environments. Jellyfish are marine animals with the ability to utilize their venom in order to both feed and defend. Prior studies have displayed the anticancer capabilities of various jellyfish. Hence, we examined the anticancer features of the venom of <i>Cassiopea andromeda</i> and <i>Catostylus mosaicus</i> in an in vitro situation against the human pulmonary adenocarcinoma (A549) cancer cell line. The MTT assay demonstrated that both mentioned venoms have anti-tumoral ability in a dose-dependent manner. Western blot analysis proved that both venoms can increase some pro-apoptotic factors and reduce some anti-apoptotic molecules that lead to the inducing of apoptosis in A549 cells. GC/MS analysis demonstrated some compounds with biological effects, including anti-inflammatory, antioxidant and anti-cancer activities. Molecular docking and molecular dynamic showed the best position of each biologically active component on the different death receptors, which are involved in the process of apoptosis in A549 cells. Ultimately, this study has proven that both venoms of <i>C. andromeda</i> and <i>C. mosaicus</i> have the capability to suppress A549 cells in an in vitro condition and they might be utilized in order to design and develop brand new anticancer agents in the near future. |
| first_indexed | 2024-03-11T06:16:38Z |
| format | Article |
| id | doaj.art-c835124420b9446fbe8687189530e4a2 |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-03-11T06:16:38Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-c835124420b9446fbe8687189530e4a22023-11-17T12:17:29ZengMDPI AGMarine Drugs1660-33972023-03-0121316810.3390/md21030168Chemical Compositions and Experimental and Computational Modeling of the Anticancer Effects of Cnidocyte Venoms of Jellyfish <i>Cassiopea andromeda</i> and <i>Catostylus mosaicus</i> on Human Adenocarcinoma A549 CellsAfshin Zare0Alireza Afshar1Arezoo Khoradmehr2Neda Baghban3Gholamhossein Mohebbi4Alireza Barmak5Adel Daneshi6Afshar Bargahi7Iraj Nabipour8Sahar Almasi-Turk9Alireza Arandian10Mohammad Ismail Zibaii11Hamid Latifi12Amin Tamadon13Student Research Committee, Bushehr University of Medical Sciences, Bushehr 75, IranStudent Research Committee, Bushehr University of Medical Sciences, Bushehr 75, IranThe Persian Gulf Marine Biotechnology Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr 73, IranThe Persian Gulf Marine Biotechnology Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr 73, IranThe Persian Gulf Marine Biotechnology Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr 73, IranFood Lab, Bushehr University of Medical Sciences, Bushehr 73, IranThe Persian Gulf Marine Biotechnology Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr 73, IranThe Persian Gulf Marine Biotechnology Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr 73, IranThe Persian Gulf Marine Biotechnology Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr 73, IranDepartment of Anatomical Sciences, School of Medicine, Bushehr University of Medical Sciences, Bushehr 73, IranLaser and Plasma Research Institute, Shahid Beheshti University, Tehran 11, IranLaser and Plasma Research Institute, Shahid Beheshti University, Tehran 11, IranLaser and Plasma Research Institute, Shahid Beheshti University, Tehran 11, IranPerciaVista R&D Co., Shiraz 73, IranNowadays, major attention is being paid to curing different types of cancers and is focused on natural resources, including oceans and marine environments. Jellyfish are marine animals with the ability to utilize their venom in order to both feed and defend. Prior studies have displayed the anticancer capabilities of various jellyfish. Hence, we examined the anticancer features of the venom of <i>Cassiopea andromeda</i> and <i>Catostylus mosaicus</i> in an in vitro situation against the human pulmonary adenocarcinoma (A549) cancer cell line. The MTT assay demonstrated that both mentioned venoms have anti-tumoral ability in a dose-dependent manner. Western blot analysis proved that both venoms can increase some pro-apoptotic factors and reduce some anti-apoptotic molecules that lead to the inducing of apoptosis in A549 cells. GC/MS analysis demonstrated some compounds with biological effects, including anti-inflammatory, antioxidant and anti-cancer activities. Molecular docking and molecular dynamic showed the best position of each biologically active component on the different death receptors, which are involved in the process of apoptosis in A549 cells. Ultimately, this study has proven that both venoms of <i>C. andromeda</i> and <i>C. mosaicus</i> have the capability to suppress A549 cells in an in vitro condition and they might be utilized in order to design and develop brand new anticancer agents in the near future.https://www.mdpi.com/1660-3397/21/3/168jellyfishapoptosisvenompulmonary adenocarcinomamolecular docking |
| spellingShingle | Afshin Zare Alireza Afshar Arezoo Khoradmehr Neda Baghban Gholamhossein Mohebbi Alireza Barmak Adel Daneshi Afshar Bargahi Iraj Nabipour Sahar Almasi-Turk Alireza Arandian Mohammad Ismail Zibaii Hamid Latifi Amin Tamadon Chemical Compositions and Experimental and Computational Modeling of the Anticancer Effects of Cnidocyte Venoms of Jellyfish <i>Cassiopea andromeda</i> and <i>Catostylus mosaicus</i> on Human Adenocarcinoma A549 Cells Marine Drugs jellyfish apoptosis venom pulmonary adenocarcinoma molecular docking |
| title | Chemical Compositions and Experimental and Computational Modeling of the Anticancer Effects of Cnidocyte Venoms of Jellyfish <i>Cassiopea andromeda</i> and <i>Catostylus mosaicus</i> on Human Adenocarcinoma A549 Cells |
| title_full | Chemical Compositions and Experimental and Computational Modeling of the Anticancer Effects of Cnidocyte Venoms of Jellyfish <i>Cassiopea andromeda</i> and <i>Catostylus mosaicus</i> on Human Adenocarcinoma A549 Cells |
| title_fullStr | Chemical Compositions and Experimental and Computational Modeling of the Anticancer Effects of Cnidocyte Venoms of Jellyfish <i>Cassiopea andromeda</i> and <i>Catostylus mosaicus</i> on Human Adenocarcinoma A549 Cells |
| title_full_unstemmed | Chemical Compositions and Experimental and Computational Modeling of the Anticancer Effects of Cnidocyte Venoms of Jellyfish <i>Cassiopea andromeda</i> and <i>Catostylus mosaicus</i> on Human Adenocarcinoma A549 Cells |
| title_short | Chemical Compositions and Experimental and Computational Modeling of the Anticancer Effects of Cnidocyte Venoms of Jellyfish <i>Cassiopea andromeda</i> and <i>Catostylus mosaicus</i> on Human Adenocarcinoma A549 Cells |
| title_sort | chemical compositions and experimental and computational modeling of the anticancer effects of cnidocyte venoms of jellyfish i cassiopea andromeda i and i catostylus mosaicus i on human adenocarcinoma a549 cells |
| topic | jellyfish apoptosis venom pulmonary adenocarcinoma molecular docking |
| url | https://www.mdpi.com/1660-3397/21/3/168 |
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