Polypharmacology of Berberine Based on Multi-Target Binding Motifs

Polypharmacology of Berberine Based on Multi-Target Binding Motifs

Background: Polypharmacology is emerging as the next paradigm in drug discovery. However, considerable challenges still exist for polypharmacology modeling. In this study, we developed a rational design to identify highly potential targets (HPTs) for polypharmacological drugs, such as berberine.Meth...

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Bibliographic Details
Main Authors: Ming Chu, Xi Chen, Jing Wang, Likai Guo, Qianqian Wang, Zirui Gao, Jiarui Kang, Mingbo Zhang, Jinqiu Feng, Qi Guo, Binghua Li, Chengrui Zhang, Xueyuan Guo, Zhengyun Chu, Yuedan Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Pharmacology
Subjects:
berberine
polypharmacology
multi-target binding motifs
drug-target space
Alzheimer’s disease
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.00801/full

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