Improving the Efficiency of Electrocatalysis of Cytochrome P450 3A4 by Modifying the Electrode with Membrane Protein Streptolysin O for Studying the Metabolic Transformations of Drugs

Improving the Efficiency of Electrocatalysis of Cytochrome P450 3A4 by Modifying the Electrode with Membrane Protein Streptolysin O for Studying the Metabolic Transformations of Drugs

In the present work, screen-printed electrodes (SPE) modified with a synthetic surfactant, didodecyldimethylammonium bromide (DDAB) and streptolysin O (SLO) were prepared for cytochrome P450 3A4 (CYP3A4) immobilization, direct non-catalytic and catalytic electrochemistry. The immobilized CYP3A4 demo...

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Bibliographic Details
Main Authors: Polina I. Koroleva, Andrei A. Gilep, Sergey V. Kraevsky, Tatiana V. Tsybruk, Victoria V. Shumyantseva
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Biosensors
Subjects:
cytochrome P450 3A4
electrochemical analysis
streptolysin O
erythromycin
bioreactor
electron transfer
Online Access:https://www.mdpi.com/2079-6374/13/4/457

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