Radially patterned transplantable biodegradable scaffolds as topographically defined contact guidance platforms for accelerating bone regeneration
Abstract Background The healing of large critical-sized bone defects remains a clinical challenge in modern orthopedic medicine. The current gold standard for treating critical-sized bone defects is autologous bone graft; however, it has critical limitations. Bone tissue engineering has been propose...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-03-01
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| Series: | Journal of Biological Engineering |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13036-021-00263-8 |
| _version_ | 1818414479996616704 |
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| author | Yonghyun Gwon Sunho Park Woochan Kim Taeseong Han Hyoseong Kim Jangho Kim |
| author_facet | Yonghyun Gwon Sunho Park Woochan Kim Taeseong Han Hyoseong Kim Jangho Kim |
| author_sort | Yonghyun Gwon |
| collection | DOAJ |
| description | Abstract Background The healing of large critical-sized bone defects remains a clinical challenge in modern orthopedic medicine. The current gold standard for treating critical-sized bone defects is autologous bone graft; however, it has critical limitations. Bone tissue engineering has been proposed as a viable alternative, not only for replacing the current standard treatment, but also for producing complete regeneration of bone tissue without complex surgical treatments or tissue transplantation. In this study, we proposed a transplantable radially patterned scaffold for bone regeneration that was defined by capillary force lithography technology using biodegradable polycaprolactone polymer. Results The radially patterned transplantable biodegradable scaffolds had a radial structure aligned in a central direction. The radially aligned pattern significantly promoted the recruitment of host cells and migration of osteoblasts into the defect site. Furthermore, the transplantable scaffolds promoted regeneration of critical-sized bone defects by inducing cell migration and differentiation. Conclusions Our findings demonstrated that topographically defined radially patterned transplantable biodegradable scaffolds may have great potential for clinical application of bone tissue regeneration. |
| first_indexed | 2024-12-14T11:19:46Z |
| format | Article |
| id | doaj.art-c837c96f66d848b3b6d33236ab2ab8b2 |
| institution | Directory Open Access Journal |
| issn | 1754-1611 |
| language | English |
| last_indexed | 2024-12-14T11:19:46Z |
| publishDate | 2021-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Biological Engineering |
| spelling | doaj.art-c837c96f66d848b3b6d33236ab2ab8b22022-12-21T23:03:50ZengBMCJournal of Biological Engineering1754-16112021-03-0115111410.1186/s13036-021-00263-8Radially patterned transplantable biodegradable scaffolds as topographically defined contact guidance platforms for accelerating bone regenerationYonghyun Gwon0Sunho Park1Woochan Kim2Taeseong Han3Hyoseong Kim4Jangho Kim5Department of Rural and Biosystems Engineering, Chonnam National UniversityDepartment of Rural and Biosystems Engineering, Chonnam National UniversityDepartment of Rural and Biosystems Engineering, Chonnam National UniversityDepartment of Rural and Biosystems Engineering, Chonnam National UniversityDepartment of Rural and Biosystems Engineering, Chonnam National UniversityDepartment of Rural and Biosystems Engineering, Chonnam National UniversityAbstract Background The healing of large critical-sized bone defects remains a clinical challenge in modern orthopedic medicine. The current gold standard for treating critical-sized bone defects is autologous bone graft; however, it has critical limitations. Bone tissue engineering has been proposed as a viable alternative, not only for replacing the current standard treatment, but also for producing complete regeneration of bone tissue without complex surgical treatments or tissue transplantation. In this study, we proposed a transplantable radially patterned scaffold for bone regeneration that was defined by capillary force lithography technology using biodegradable polycaprolactone polymer. Results The radially patterned transplantable biodegradable scaffolds had a radial structure aligned in a central direction. The radially aligned pattern significantly promoted the recruitment of host cells and migration of osteoblasts into the defect site. Furthermore, the transplantable scaffolds promoted regeneration of critical-sized bone defects by inducing cell migration and differentiation. Conclusions Our findings demonstrated that topographically defined radially patterned transplantable biodegradable scaffolds may have great potential for clinical application of bone tissue regeneration.https://doi.org/10.1186/s13036-021-00263-8Critical-sized bone defectBone tissue engineeringRadially patternTransplantableBiodegradable scaffold |
| spellingShingle | Yonghyun Gwon Sunho Park Woochan Kim Taeseong Han Hyoseong Kim Jangho Kim Radially patterned transplantable biodegradable scaffolds as topographically defined contact guidance platforms for accelerating bone regeneration Journal of Biological Engineering Critical-sized bone defect Bone tissue engineering Radially pattern Transplantable Biodegradable scaffold |
| title | Radially patterned transplantable biodegradable scaffolds as topographically defined contact guidance platforms for accelerating bone regeneration |
| title_full | Radially patterned transplantable biodegradable scaffolds as topographically defined contact guidance platforms for accelerating bone regeneration |
| title_fullStr | Radially patterned transplantable biodegradable scaffolds as topographically defined contact guidance platforms for accelerating bone regeneration |
| title_full_unstemmed | Radially patterned transplantable biodegradable scaffolds as topographically defined contact guidance platforms for accelerating bone regeneration |
| title_short | Radially patterned transplantable biodegradable scaffolds as topographically defined contact guidance platforms for accelerating bone regeneration |
| title_sort | radially patterned transplantable biodegradable scaffolds as topographically defined contact guidance platforms for accelerating bone regeneration |
| topic | Critical-sized bone defect Bone tissue engineering Radially pattern Transplantable Biodegradable scaffold |
| url | https://doi.org/10.1186/s13036-021-00263-8 |
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