Porcine Reproductive and Respiratory Syndrome Virus: Origin Hypothesis
Porcine reproductive and respiratory syndrome is a serious swine disease that appeared suddenly in the midwestern United States and central Europe approximately 14 years ago; the disease has now spread worldwide. In North America and Europe, the syndrome is caused by two genotypes of porcine reprodu...
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| Format: | Article |
| Language: | English |
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Centers for Disease Control and Prevention
2003-08-01
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| Series: | Emerging Infectious Diseases |
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| Online Access: | https://wwwnc.cdc.gov/eid/article/9/8/03-0232_article |
| _version_ | 1811261957131468800 |
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| author | Peter G.W. Plagemann |
| author_facet | Peter G.W. Plagemann |
| author_sort | Peter G.W. Plagemann |
| collection | DOAJ |
| description | Porcine reproductive and respiratory syndrome is a serious swine disease that appeared suddenly in the midwestern United States and central Europe approximately 14 years ago; the disease has now spread worldwide. In North America and Europe, the syndrome is caused by two genotypes of porcine reproductive and respiratory syndrome virus (PRRSV), an arterivirus whose genomes diverge by approximately 40%. My hypothesis, which explains the origin and evolution of the two distinct PRRSV genotypes, is that a mutant of a closely related arterivirus of mice (lactate dehydrogenase-elevating virus) infected wild boars in central Europe. These wild boars functioned as intermediate hosts and spread the virus to North Carolina in imported, infected European wild boars in 1912; the virus then evolved independently on the two continents in the prevalent wild hog populations for approximately 70 years until independently entering the domestic pig population. |
| first_indexed | 2024-04-12T19:16:09Z |
| format | Article |
| id | doaj.art-c839b97722fd4e2fb51f8a8a25eb3535 |
| institution | Directory Open Access Journal |
| issn | 1080-6040 1080-6059 |
| language | English |
| last_indexed | 2024-04-12T19:16:09Z |
| publishDate | 2003-08-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj.art-c839b97722fd4e2fb51f8a8a25eb35352022-12-22T03:19:45ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592003-08-019890390810.3201/eid0908.030232Porcine Reproductive and Respiratory Syndrome Virus: Origin HypothesisPeter G.W. PlagemannPorcine reproductive and respiratory syndrome is a serious swine disease that appeared suddenly in the midwestern United States and central Europe approximately 14 years ago; the disease has now spread worldwide. In North America and Europe, the syndrome is caused by two genotypes of porcine reproductive and respiratory syndrome virus (PRRSV), an arterivirus whose genomes diverge by approximately 40%. My hypothesis, which explains the origin and evolution of the two distinct PRRSV genotypes, is that a mutant of a closely related arterivirus of mice (lactate dehydrogenase-elevating virus) infected wild boars in central Europe. These wild boars functioned as intermediate hosts and spread the virus to North Carolina in imported, infected European wild boars in 1912; the virus then evolved independently on the two continents in the prevalent wild hog populations for approximately 70 years until independently entering the domestic pig population.https://wwwnc.cdc.gov/eid/article/9/8/03-0232_articlearteriviruseslactate dehydrogenase-elevating virusporcine reproductive and respiratory syndrome virusUnited Statesvirus evolution |
| spellingShingle | Peter G.W. Plagemann Porcine Reproductive and Respiratory Syndrome Virus: Origin Hypothesis Emerging Infectious Diseases arteriviruses lactate dehydrogenase-elevating virus porcine reproductive and respiratory syndrome virus United States virus evolution |
| title | Porcine Reproductive and Respiratory Syndrome Virus: Origin Hypothesis |
| title_full | Porcine Reproductive and Respiratory Syndrome Virus: Origin Hypothesis |
| title_fullStr | Porcine Reproductive and Respiratory Syndrome Virus: Origin Hypothesis |
| title_full_unstemmed | Porcine Reproductive and Respiratory Syndrome Virus: Origin Hypothesis |
| title_short | Porcine Reproductive and Respiratory Syndrome Virus: Origin Hypothesis |
| title_sort | porcine reproductive and respiratory syndrome virus origin hypothesis |
| topic | arteriviruses lactate dehydrogenase-elevating virus porcine reproductive and respiratory syndrome virus United States virus evolution |
| url | https://wwwnc.cdc.gov/eid/article/9/8/03-0232_article |
| work_keys_str_mv | AT petergwplagemann porcinereproductiveandrespiratorysyndromevirusoriginhypothesis |