ETV2/ER71, the key factor leading the paths to vascular regeneration and angiogenic reprogramming
Abstract Extensive efforts have been made to achieve vascular regeneration accompanying tissue repair for treating vascular dysfunction-associated diseases. Recent advancements in stem cell biology and cell reprogramming have opened unforeseen opportunities to promote angiogenesis in vivo and genera...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2023-03-01
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| Series: | Stem Cell Research & Therapy |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13287-023-03267-x |
| _version_ | 1827985071298052096 |
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| author | Tae Min Kim Ra Ham Lee Min Seong Kim Chloe A. Lewis Changwon Park |
| author_facet | Tae Min Kim Ra Ham Lee Min Seong Kim Chloe A. Lewis Changwon Park |
| author_sort | Tae Min Kim |
| collection | DOAJ |
| description | Abstract Extensive efforts have been made to achieve vascular regeneration accompanying tissue repair for treating vascular dysfunction-associated diseases. Recent advancements in stem cell biology and cell reprogramming have opened unforeseen opportunities to promote angiogenesis in vivo and generate autologous endothelial cells (ECs) for clinical use. We have, for the first time, identified a unique endothelial-specific transcription factor, ETV2/ER71, and revealed its essential role in regulating endothelial cell generation and function, along with vascular regeneration and tissue repair. Furthermore, we and other groups have demonstrated its ability to directly reprogram terminally differentiated non-ECs into functional ECs, proposing ETV2/ER71 as an effective therapeutic target for vascular diseases. In this review, we discuss the up-to-date status of studies on ETV2/ER71, spanning from its molecular mechanism to vasculo-angiogenic role and direct cell reprogramming toward ECs. Furthermore, we discuss future directions to deploy the clinical potential of ETV2/ER71 as a novel and potent target for vascular disorders such as cardiovascular disease, neurovascular impairment and cancer. |
| first_indexed | 2024-04-09T23:07:51Z |
| format | Article |
| id | doaj.art-c83c5ca58de844a3847f308709e1e376 |
| institution | Directory Open Access Journal |
| issn | 1757-6512 |
| language | English |
| last_indexed | 2024-04-09T23:07:51Z |
| publishDate | 2023-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Stem Cell Research & Therapy |
| spelling | doaj.art-c83c5ca58de844a3847f308709e1e3762023-03-22T10:34:59ZengBMCStem Cell Research & Therapy1757-65122023-03-0114111610.1186/s13287-023-03267-xETV2/ER71, the key factor leading the paths to vascular regeneration and angiogenic reprogrammingTae Min Kim0Ra Ham Lee1Min Seong Kim2Chloe A. Lewis3Changwon Park4Graduate School of International Agricultural Technology and Institutes of Green-Bio Science and Technology, Seoul National UniversityDepartment of Molecular and Cellular Physiology, Louisiana State University Health Science CenterDepartment of Molecular and Cellular Physiology, Louisiana State University Health Science CenterDepartment of Molecular and Cellular Physiology, Louisiana State University Health Science CenterDepartment of Molecular and Cellular Physiology, Louisiana State University Health Science CenterAbstract Extensive efforts have been made to achieve vascular regeneration accompanying tissue repair for treating vascular dysfunction-associated diseases. Recent advancements in stem cell biology and cell reprogramming have opened unforeseen opportunities to promote angiogenesis in vivo and generate autologous endothelial cells (ECs) for clinical use. We have, for the first time, identified a unique endothelial-specific transcription factor, ETV2/ER71, and revealed its essential role in regulating endothelial cell generation and function, along with vascular regeneration and tissue repair. Furthermore, we and other groups have demonstrated its ability to directly reprogram terminally differentiated non-ECs into functional ECs, proposing ETV2/ER71 as an effective therapeutic target for vascular diseases. In this review, we discuss the up-to-date status of studies on ETV2/ER71, spanning from its molecular mechanism to vasculo-angiogenic role and direct cell reprogramming toward ECs. Furthermore, we discuss future directions to deploy the clinical potential of ETV2/ER71 as a novel and potent target for vascular disorders such as cardiovascular disease, neurovascular impairment and cancer.https://doi.org/10.1186/s13287-023-03267-xER71/ETV2Endothelial cellsVascular regenerationDirect cell reprogramming |
| spellingShingle | Tae Min Kim Ra Ham Lee Min Seong Kim Chloe A. Lewis Changwon Park ETV2/ER71, the key factor leading the paths to vascular regeneration and angiogenic reprogramming Stem Cell Research & Therapy ER71/ETV2 Endothelial cells Vascular regeneration Direct cell reprogramming |
| title | ETV2/ER71, the key factor leading the paths to vascular regeneration and angiogenic reprogramming |
| title_full | ETV2/ER71, the key factor leading the paths to vascular regeneration and angiogenic reprogramming |
| title_fullStr | ETV2/ER71, the key factor leading the paths to vascular regeneration and angiogenic reprogramming |
| title_full_unstemmed | ETV2/ER71, the key factor leading the paths to vascular regeneration and angiogenic reprogramming |
| title_short | ETV2/ER71, the key factor leading the paths to vascular regeneration and angiogenic reprogramming |
| title_sort | etv2 er71 the key factor leading the paths to vascular regeneration and angiogenic reprogramming |
| topic | ER71/ETV2 Endothelial cells Vascular regeneration Direct cell reprogramming |
| url | https://doi.org/10.1186/s13287-023-03267-x |
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