Beraprost and Overall Survival in Cats with Chronic Kidney Disease
Background: Overall survival is the most important outcome for treatment response in feline chronic kidney disease (CKD). Beraprost has been shown to reduce the kidney function decline in cats with International Renal Interest Society (IRIS) stage 2 and 3 CKD. However, the association with prolonged...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-07-01
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| Series: | Veterinary Sciences |
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| Online Access: | https://www.mdpi.com/2306-7381/10/7/459 |
| _version_ | 1827731615360483328 |
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| author | Hiroyuki Ito Takumi Matsuura Tadashi Sano |
| author_facet | Hiroyuki Ito Takumi Matsuura Tadashi Sano |
| author_sort | Hiroyuki Ito |
| collection | DOAJ |
| description | Background: Overall survival is the most important outcome for treatment response in feline chronic kidney disease (CKD). Beraprost has been shown to reduce the kidney function decline in cats with International Renal Interest Society (IRIS) stage 2 and 3 CKD. However, the association with prolonged survival has not yet been examined. Objective: To assess the relationship between beraprost and overall survival in cats with CKD in real clinical practice. Animals: Client-owned cats with IRIS stage 3 CKD (<i>n</i> = 134) were evaluated between 2017 and 2020. Methods: A retrospective cohort study based on data from electronic medical records of one hospital. Results: The cohort was divided into “beraprost therapy” and “no beraprost therapy” groups, and survival analyses revealed that overall survival was significantly longer in the beraprost therapy group, using Kaplan–Meier curves (<i>p</i> = 0.004). However, baseline phosphate is known to be an important prognostic indicator and was not well balanced between the two groups. Therefore, a subcohort of 97 cats was selected (those having baseline phosphate <6.0 mg/dL) that allowed for this parameter to be balanced between groups. The survival data in this subcohort were consistent with those of the overall study cohort. Conclusions: In feline patients with CKD, beraprost therapy is associated with better overall survival. |
| first_indexed | 2024-03-11T00:34:35Z |
| format | Article |
| id | doaj.art-c83cb77f496d4c83924b8fff000be053 |
| institution | Directory Open Access Journal |
| issn | 2306-7381 |
| language | English |
| last_indexed | 2024-03-11T00:34:35Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Veterinary Sciences |
| spelling | doaj.art-c83cb77f496d4c83924b8fff000be0532023-11-18T21:42:53ZengMDPI AGVeterinary Sciences2306-73812023-07-0110745910.3390/vetsci10070459Beraprost and Overall Survival in Cats with Chronic Kidney DiseaseHiroyuki Ito0Takumi Matsuura1Tadashi Sano2Ichikawa General Hospital, Kariya Animal Hospital Group, Chiba 272-0034, JapanToray Industries, Inc., Tokyo 103-8666, JapanSchool of Veterinary Medicine, Rakuno Gakuen University, Hokkaido 069-8501, JapanBackground: Overall survival is the most important outcome for treatment response in feline chronic kidney disease (CKD). Beraprost has been shown to reduce the kidney function decline in cats with International Renal Interest Society (IRIS) stage 2 and 3 CKD. However, the association with prolonged survival has not yet been examined. Objective: To assess the relationship between beraprost and overall survival in cats with CKD in real clinical practice. Animals: Client-owned cats with IRIS stage 3 CKD (<i>n</i> = 134) were evaluated between 2017 and 2020. Methods: A retrospective cohort study based on data from electronic medical records of one hospital. Results: The cohort was divided into “beraprost therapy” and “no beraprost therapy” groups, and survival analyses revealed that overall survival was significantly longer in the beraprost therapy group, using Kaplan–Meier curves (<i>p</i> = 0.004). However, baseline phosphate is known to be an important prognostic indicator and was not well balanced between the two groups. Therefore, a subcohort of 97 cats was selected (those having baseline phosphate <6.0 mg/dL) that allowed for this parameter to be balanced between groups. The survival data in this subcohort were consistent with those of the overall study cohort. Conclusions: In feline patients with CKD, beraprost therapy is associated with better overall survival.https://www.mdpi.com/2306-7381/10/7/459beraprostfelinechronic kidney diseaseprogression-free survivaloverall survival |
| spellingShingle | Hiroyuki Ito Takumi Matsuura Tadashi Sano Beraprost and Overall Survival in Cats with Chronic Kidney Disease Veterinary Sciences beraprost feline chronic kidney disease progression-free survival overall survival |
| title | Beraprost and Overall Survival in Cats with Chronic Kidney Disease |
| title_full | Beraprost and Overall Survival in Cats with Chronic Kidney Disease |
| title_fullStr | Beraprost and Overall Survival in Cats with Chronic Kidney Disease |
| title_full_unstemmed | Beraprost and Overall Survival in Cats with Chronic Kidney Disease |
| title_short | Beraprost and Overall Survival in Cats with Chronic Kidney Disease |
| title_sort | beraprost and overall survival in cats with chronic kidney disease |
| topic | beraprost feline chronic kidney disease progression-free survival overall survival |
| url | https://www.mdpi.com/2306-7381/10/7/459 |
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