Triterpenoids from the Roots of Sanguisorba tenuifolia var. Alba
The ethyl acetate soluble fraction from the roots of Sanguisorba tenuifolia was found to have a hypoglucemic effect in alloxan-induced diabetic rats. Two new triterpenoids, identified as 2-oxo-3β,19α-dihydroxyolean-12-en-28-oic acid β-D-gluco-pyranosyl ester (1) and 2α,19α-dihydroxy-3-oxo-12-ursen-2...
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| Format: | Article |
| Language: | English |
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MDPI AG
2011-06-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/16/6/4642/ |
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| author | Zhi-Bin Wang Bing-You Yang Hai-Xue Kuang Qiu-Hong Wang Hong-Wei Li Yong-Gang Xia |
| author_facet | Zhi-Bin Wang Bing-You Yang Hai-Xue Kuang Qiu-Hong Wang Hong-Wei Li Yong-Gang Xia |
| author_sort | Zhi-Bin Wang |
| collection | DOAJ |
| description | The ethyl acetate soluble fraction from the roots of Sanguisorba tenuifolia was found to have a hypoglucemic effect in alloxan-induced diabetic rats. Two new triterpenoids, identified as 2-oxo-3β,19α-dihydroxyolean-12-en-28-oic acid β-D-gluco-pyranosyl ester (1) and 2α,19α-dihydroxy-3-oxo-12-ursen-28-oic acid β-D-glucopyranosyl ester (4) were isolated from this fraction, along with thirteen known triterpenoids. Their structures were elucidated by chemical and spectroscopic methods. All these compounds demonstrated inhibitory activities against α-glucosidase with IC50 values in the 0.62-3.62 mM range. |
| first_indexed | 2024-04-12T02:41:14Z |
| format | Article |
| id | doaj.art-c83d60a1c3b64efc95f9502872d0afc0 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-04-12T02:41:14Z |
| publishDate | 2011-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-c83d60a1c3b64efc95f9502872d0afc02022-12-22T03:51:19ZengMDPI AGMolecules1420-30492011-06-011664642465110.3390/molecules16064642Triterpenoids from the Roots of Sanguisorba tenuifolia var. AlbaZhi-Bin WangBing-You YangHai-Xue KuangQiu-Hong WangHong-Wei LiYong-Gang XiaThe ethyl acetate soluble fraction from the roots of Sanguisorba tenuifolia was found to have a hypoglucemic effect in alloxan-induced diabetic rats. Two new triterpenoids, identified as 2-oxo-3β,19α-dihydroxyolean-12-en-28-oic acid β-D-gluco-pyranosyl ester (1) and 2α,19α-dihydroxy-3-oxo-12-ursen-28-oic acid β-D-glucopyranosyl ester (4) were isolated from this fraction, along with thirteen known triterpenoids. Their structures were elucidated by chemical and spectroscopic methods. All these compounds demonstrated inhibitory activities against α-glucosidase with IC50 values in the 0.62-3.62 mM range.http://www.mdpi.com/1420-3049/16/6/4642/Sanguisorba tenuifolia var. Albatriterpenoidsα-glucosidase inhibitory activitydiabetes mellitus |
| spellingShingle | Zhi-Bin Wang Bing-You Yang Hai-Xue Kuang Qiu-Hong Wang Hong-Wei Li Yong-Gang Xia Triterpenoids from the Roots of Sanguisorba tenuifolia var. Alba Molecules Sanguisorba tenuifolia var. Alba triterpenoids α-glucosidase inhibitory activity diabetes mellitus |
| title | Triterpenoids from the Roots of Sanguisorba tenuifolia var. Alba |
| title_full | Triterpenoids from the Roots of Sanguisorba tenuifolia var. Alba |
| title_fullStr | Triterpenoids from the Roots of Sanguisorba tenuifolia var. Alba |
| title_full_unstemmed | Triterpenoids from the Roots of Sanguisorba tenuifolia var. Alba |
| title_short | Triterpenoids from the Roots of Sanguisorba tenuifolia var. Alba |
| title_sort | triterpenoids from the roots of sanguisorba tenuifolia var alba |
| topic | Sanguisorba tenuifolia var. Alba triterpenoids α-glucosidase inhibitory activity diabetes mellitus |
| url | http://www.mdpi.com/1420-3049/16/6/4642/ |
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