Emergence of Nanotechnology as a Powerful Cavalry against Triple-Negative Breast Cancer (TNBC)
Triple-negative breast cancer (TNBC) is considered one of the un-manageable types of breast cancer, involving devoid of estrogen, progesterone, and human epidermal growth factor receptor 2 (HER 2) receptors. Due to their ability of recurrence and metastasis, the management of TNBC remains a mainstay...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-04-01
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| Series: | Pharmaceuticals |
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| Online Access: | https://www.mdpi.com/1424-8247/15/5/542 |
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| author | Aiswarya Chaudhuri Dulla Naveen Kumar Deepa Dehari Sanjay Singh Pradeep Kumar Pradeep Kumar Bolla Dinesh Kumar Ashish Kumar Agrawal |
| author_facet | Aiswarya Chaudhuri Dulla Naveen Kumar Deepa Dehari Sanjay Singh Pradeep Kumar Pradeep Kumar Bolla Dinesh Kumar Ashish Kumar Agrawal |
| author_sort | Aiswarya Chaudhuri |
| collection | DOAJ |
| description | Triple-negative breast cancer (TNBC) is considered one of the un-manageable types of breast cancer, involving devoid of estrogen, progesterone, and human epidermal growth factor receptor 2 (HER 2) receptors. Due to their ability of recurrence and metastasis, the management of TNBC remains a mainstay challenge, despite the advancements in cancer therapies. Conventional chemotherapy remains the only treatment regimen against TNBC and suffers several limitations such as low bioavailability, systemic toxicity, less targetability, and multi-drug resistance. Although various targeted therapies have been introduced to manage the hardship of TNBC, they still experience certain limitations associated with the survival benefits. The current research thus aimed at developing and improving the strategies for effective therapy against TNBC. Such strategies involved the emergence of nanoparticles. Nanoparticles are designated as nanocavalries, loaded with various agents (drugs, genes, etc.) to battle the progression and metastasis of TNBC along with overcoming the limitations experienced by conventional chemotherapy and targeted therapy. This article documents the treatment regimens of TNBC along with their efficacy towards different subtypes of TNBC, and the various nanotechnologies employed to increase the therapeutic outcome of FDA-approved drug regimens. |
| first_indexed | 2024-03-10T03:10:50Z |
| format | Article |
| id | doaj.art-c8463e838ad2485fae57893996481c95 |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-10T03:10:50Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-c8463e838ad2485fae57893996481c952023-11-23T12:34:14ZengMDPI AGPharmaceuticals1424-82472022-04-0115554210.3390/ph15050542Emergence of Nanotechnology as a Powerful Cavalry against Triple-Negative Breast Cancer (TNBC)Aiswarya Chaudhuri0Dulla Naveen Kumar1Deepa Dehari2Sanjay Singh3Pradeep Kumar4Pradeep Kumar Bolla5Dinesh Kumar6Ashish Kumar Agrawal7Department of Pharmaceutical Engineering & Technology, Indian Institute of Technology (BHU), Varanasi 221005, IndiaDepartment of Pharmaceutical Engineering & Technology, Indian Institute of Technology (BHU), Varanasi 221005, IndiaDepartment of Pharmaceutical Engineering & Technology, Indian Institute of Technology (BHU), Varanasi 221005, IndiaDepartment of Pharmaceutical Engineering & Technology, Indian Institute of Technology (BHU), Varanasi 221005, IndiaDepartment of Pharmacy and Pharmacology, School of Therapeutic Sciences, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg 2193, South AfricaDepartment of Biomedical Engineering, College of Engineering, The University of Texas at El Paso, 500 W. University Ave, El Paso, TX 79968, USADepartment of Pharmaceutical Engineering & Technology, Indian Institute of Technology (BHU), Varanasi 221005, IndiaDepartment of Pharmaceutical Engineering & Technology, Indian Institute of Technology (BHU), Varanasi 221005, IndiaTriple-negative breast cancer (TNBC) is considered one of the un-manageable types of breast cancer, involving devoid of estrogen, progesterone, and human epidermal growth factor receptor 2 (HER 2) receptors. Due to their ability of recurrence and metastasis, the management of TNBC remains a mainstay challenge, despite the advancements in cancer therapies. Conventional chemotherapy remains the only treatment regimen against TNBC and suffers several limitations such as low bioavailability, systemic toxicity, less targetability, and multi-drug resistance. Although various targeted therapies have been introduced to manage the hardship of TNBC, they still experience certain limitations associated with the survival benefits. The current research thus aimed at developing and improving the strategies for effective therapy against TNBC. Such strategies involved the emergence of nanoparticles. Nanoparticles are designated as nanocavalries, loaded with various agents (drugs, genes, etc.) to battle the progression and metastasis of TNBC along with overcoming the limitations experienced by conventional chemotherapy and targeted therapy. This article documents the treatment regimens of TNBC along with their efficacy towards different subtypes of TNBC, and the various nanotechnologies employed to increase the therapeutic outcome of FDA-approved drug regimens.https://www.mdpi.com/1424-8247/15/5/542chemotherapynanoparticlestargeted therapytriple-negative breast cancer (TNBC) |
| spellingShingle | Aiswarya Chaudhuri Dulla Naveen Kumar Deepa Dehari Sanjay Singh Pradeep Kumar Pradeep Kumar Bolla Dinesh Kumar Ashish Kumar Agrawal Emergence of Nanotechnology as a Powerful Cavalry against Triple-Negative Breast Cancer (TNBC) Pharmaceuticals chemotherapy nanoparticles targeted therapy triple-negative breast cancer (TNBC) |
| title | Emergence of Nanotechnology as a Powerful Cavalry against Triple-Negative Breast Cancer (TNBC) |
| title_full | Emergence of Nanotechnology as a Powerful Cavalry against Triple-Negative Breast Cancer (TNBC) |
| title_fullStr | Emergence of Nanotechnology as a Powerful Cavalry against Triple-Negative Breast Cancer (TNBC) |
| title_full_unstemmed | Emergence of Nanotechnology as a Powerful Cavalry against Triple-Negative Breast Cancer (TNBC) |
| title_short | Emergence of Nanotechnology as a Powerful Cavalry against Triple-Negative Breast Cancer (TNBC) |
| title_sort | emergence of nanotechnology as a powerful cavalry against triple negative breast cancer tnbc |
| topic | chemotherapy nanoparticles targeted therapy triple-negative breast cancer (TNBC) |
| url | https://www.mdpi.com/1424-8247/15/5/542 |
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