Elucidation of critical chemical moieties of metallo-β-lactamase inhibitors and prioritisation of target metallo-β-lactamases
The urgent demand for effective countermeasures against metallo-β-lactamases (MBLs) necessitates development of novel metallo-β-lactamase inhibitors (MBLIs). This study is dedicated to identifying critical chemical moieties within previously developed MBLIs, and critical MBLs should serve as the tar...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Journal of Enzyme Inhibition and Medicinal Chemistry |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/14756366.2024.2318830 |
| _version_ | 1826919920846241792 |
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| author | Jung Hun Lee Sang-Gyu Kim Kyung-Min Jang Kyoungmin Shin Hyeonku Jin Dae-Wi Kim Byeong Chul Jeong Sang Hee Lee |
| author_facet | Jung Hun Lee Sang-Gyu Kim Kyung-Min Jang Kyoungmin Shin Hyeonku Jin Dae-Wi Kim Byeong Chul Jeong Sang Hee Lee |
| author_sort | Jung Hun Lee |
| collection | DOAJ |
| description | The urgent demand for effective countermeasures against metallo-β-lactamases (MBLs) necessitates development of novel metallo-β-lactamase inhibitors (MBLIs). This study is dedicated to identifying critical chemical moieties within previously developed MBLIs, and critical MBLs should serve as the target in MBLI evaluations. Using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA), a systematic literature analysis was conducted, and the NCBI RefSeq genome database was exploited to access the abundance profile and taxonomic distribution of MBLs and their variant types. Through the implementation of two distinct systematic approaches, we elucidated critical chemical moieties of MBLIs, providing pivotal information for rational drug design. We also prioritised MBLs and their variant types, highlighting the imperative need for comprehensive testing to ensure the potency and efficacy of the newly developed MBLIs. This approach contributes valuable information to advance the field of antimicrobial drug discovery. |
| first_indexed | 2024-04-24T23:42:41Z |
| format | Article |
| id | doaj.art-c847db5836704a938c7f1d43908ced9e |
| institution | Directory Open Access Journal |
| issn | 1475-6366 1475-6374 |
| language | English |
| last_indexed | 2025-02-17T13:20:33Z |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Enzyme Inhibition and Medicinal Chemistry |
| spelling | doaj.art-c847db5836704a938c7f1d43908ced9e2024-12-26T09:30:44ZengTaylor & Francis GroupJournal of Enzyme Inhibition and Medicinal Chemistry1475-63661475-63742024-12-0139110.1080/14756366.2024.2318830Elucidation of critical chemical moieties of metallo-β-lactamase inhibitors and prioritisation of target metallo-β-lactamasesJung Hun Lee0Sang-Gyu Kim1Kyung-Min Jang2Kyoungmin Shin3Hyeonku Jin4Dae-Wi Kim5Byeong Chul Jeong6Sang Hee Lee7National Leading Research Laboratory of Drug Resistance Proteomics, Department of Biological Sciences, Myongji University, Yongin, Republic of KoreaDivision of Life Sciences, Jeonbuk National University, Jeonju, Republic of KoreaNational Leading Research Laboratory of Drug Resistance Proteomics, Department of Biological Sciences, Myongji University, Yongin, Republic of KoreaNational Leading Research Laboratory of Drug Resistance Proteomics, Department of Biological Sciences, Myongji University, Yongin, Republic of KoreaNational Leading Research Laboratory of Drug Resistance Proteomics, Department of Biological Sciences, Myongji University, Yongin, Republic of KoreaDivision of Life Sciences, Jeonbuk National University, Jeonju, Republic of KoreaNational Leading Research Laboratory of Drug Resistance Proteomics, Department of Biological Sciences, Myongji University, Yongin, Republic of KoreaNational Leading Research Laboratory of Drug Resistance Proteomics, Department of Biological Sciences, Myongji University, Yongin, Republic of KoreaThe urgent demand for effective countermeasures against metallo-β-lactamases (MBLs) necessitates development of novel metallo-β-lactamase inhibitors (MBLIs). This study is dedicated to identifying critical chemical moieties within previously developed MBLIs, and critical MBLs should serve as the target in MBLI evaluations. Using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA), a systematic literature analysis was conducted, and the NCBI RefSeq genome database was exploited to access the abundance profile and taxonomic distribution of MBLs and their variant types. Through the implementation of two distinct systematic approaches, we elucidated critical chemical moieties of MBLIs, providing pivotal information for rational drug design. We also prioritised MBLs and their variant types, highlighting the imperative need for comprehensive testing to ensure the potency and efficacy of the newly developed MBLIs. This approach contributes valuable information to advance the field of antimicrobial drug discovery.https://www.tandfonline.com/doi/10.1080/14756366.2024.2318830Metallo-β-lactamase inhibitorchemical moietymetallo-β-lactamase variant type |
| spellingShingle | Jung Hun Lee Sang-Gyu Kim Kyung-Min Jang Kyoungmin Shin Hyeonku Jin Dae-Wi Kim Byeong Chul Jeong Sang Hee Lee Elucidation of critical chemical moieties of metallo-β-lactamase inhibitors and prioritisation of target metallo-β-lactamases Journal of Enzyme Inhibition and Medicinal Chemistry Metallo-β-lactamase inhibitor chemical moiety metallo-β-lactamase variant type |
| title | Elucidation of critical chemical moieties of metallo-β-lactamase inhibitors and prioritisation of target metallo-β-lactamases |
| title_full | Elucidation of critical chemical moieties of metallo-β-lactamase inhibitors and prioritisation of target metallo-β-lactamases |
| title_fullStr | Elucidation of critical chemical moieties of metallo-β-lactamase inhibitors and prioritisation of target metallo-β-lactamases |
| title_full_unstemmed | Elucidation of critical chemical moieties of metallo-β-lactamase inhibitors and prioritisation of target metallo-β-lactamases |
| title_short | Elucidation of critical chemical moieties of metallo-β-lactamase inhibitors and prioritisation of target metallo-β-lactamases |
| title_sort | elucidation of critical chemical moieties of metallo β lactamase inhibitors and prioritisation of target metallo β lactamases |
| topic | Metallo-β-lactamase inhibitor chemical moiety metallo-β-lactamase variant type |
| url | https://www.tandfonline.com/doi/10.1080/14756366.2024.2318830 |
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