Potential antibacterial mechanism of silver nanoparticles and the optimization of orthopedic implants by advanced modification technologies
Yun’an Qing,1 Lin Cheng,2 Ruiyan Li,1 Guancong Liu,1 Yanbo Zhang,1 Xiongfeng Tang,1 Jincheng Wang,1 He Liu,1 Yanguo Qin1 1Orthopaedic Medical Center, The Second Hospital of Jilin University, Changchun 130041, People’s Republic of China; 2Department of Obstetrics and Gynecology,...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2018-06-01
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| Series: | International Journal of Nanomedicine |
| Subjects: | |
| Online Access: | https://www.dovepress.com/potential-antibacterial-mechanism-of-silver-nanoparticles-and-the-opti-peer-reviewed-article-IJN |
| _version_ | 1818982366258921472 |
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| author | Qing Y Cheng L Li R Liu G Zhang Y Tang X Wang J Liu H Qin Y |
| author_facet | Qing Y Cheng L Li R Liu G Zhang Y Tang X Wang J Liu H Qin Y |
| author_sort | Qing Y |
| collection | DOAJ |
| description | Yun’an Qing,1 Lin Cheng,2 Ruiyan Li,1 Guancong Liu,1 Yanbo Zhang,1 Xiongfeng Tang,1 Jincheng Wang,1 He Liu,1 Yanguo Qin1 1Orthopaedic Medical Center, The Second Hospital of Jilin University, Changchun 130041, People’s Republic of China; 2Department of Obstetrics and Gynecology, The Second Hospital of Jilin University, Changchun 130041, People’s Republic of China Abstract: Infection, as a common postoperative complication of orthopedic surgery, is the main reason leading to implant failure. Silver nanoparticles (AgNPs) are considered as a promising antibacterial agent and always used to modify orthopedic implants to prevent infection. To optimize the implants in a reasonable manner, it is critical for us to know the specific antibacterial mechanism, which is still unclear. In this review, we analyzed the potential antibacterial mechanisms of AgNPs, and the influences of AgNPs on osteogenic-related cells, including cellular adhesion, proliferation, and differentiation, were also discussed. In addition, methods to enhance biocompatibility of AgNPs as well as advanced implants modifications technologies were also summarized. Keywords: antibacterial mechanism, biocompatibility, osteogenic-related cells, orthopedic implants, silver nanoparticles, surface modification |
| first_indexed | 2024-12-20T17:46:04Z |
| format | Article |
| id | doaj.art-c848d0942321499d8da44ee3838b123f |
| institution | Directory Open Access Journal |
| issn | 1178-2013 |
| language | English |
| last_indexed | 2024-12-20T17:46:04Z |
| publishDate | 2018-06-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of Nanomedicine |
| spelling | doaj.art-c848d0942321499d8da44ee3838b123f2022-12-21T19:30:58ZengDove Medical PressInternational Journal of Nanomedicine1178-20132018-06-01Volume 133311332738663Potential antibacterial mechanism of silver nanoparticles and the optimization of orthopedic implants by advanced modification technologiesQing YCheng LLi RLiu GZhang YTang XWang JLiu HQin YYun’an Qing,1 Lin Cheng,2 Ruiyan Li,1 Guancong Liu,1 Yanbo Zhang,1 Xiongfeng Tang,1 Jincheng Wang,1 He Liu,1 Yanguo Qin1 1Orthopaedic Medical Center, The Second Hospital of Jilin University, Changchun 130041, People’s Republic of China; 2Department of Obstetrics and Gynecology, The Second Hospital of Jilin University, Changchun 130041, People’s Republic of China Abstract: Infection, as a common postoperative complication of orthopedic surgery, is the main reason leading to implant failure. Silver nanoparticles (AgNPs) are considered as a promising antibacterial agent and always used to modify orthopedic implants to prevent infection. To optimize the implants in a reasonable manner, it is critical for us to know the specific antibacterial mechanism, which is still unclear. In this review, we analyzed the potential antibacterial mechanisms of AgNPs, and the influences of AgNPs on osteogenic-related cells, including cellular adhesion, proliferation, and differentiation, were also discussed. In addition, methods to enhance biocompatibility of AgNPs as well as advanced implants modifications technologies were also summarized. Keywords: antibacterial mechanism, biocompatibility, osteogenic-related cells, orthopedic implants, silver nanoparticles, surface modificationhttps://www.dovepress.com/potential-antibacterial-mechanism-of-silver-nanoparticles-and-the-opti-peer-reviewed-article-IJNAntibacterial mechanismBiocompatibilityOsteogenic related cellsOrthopedic implantsSilver nanoparticlesSurface modification |
| spellingShingle | Qing Y Cheng L Li R Liu G Zhang Y Tang X Wang J Liu H Qin Y Potential antibacterial mechanism of silver nanoparticles and the optimization of orthopedic implants by advanced modification technologies International Journal of Nanomedicine Antibacterial mechanism Biocompatibility Osteogenic related cells Orthopedic implants Silver nanoparticles Surface modification |
| title | Potential antibacterial mechanism of silver nanoparticles and the optimization of orthopedic implants by advanced modification technologies |
| title_full | Potential antibacterial mechanism of silver nanoparticles and the optimization of orthopedic implants by advanced modification technologies |
| title_fullStr | Potential antibacterial mechanism of silver nanoparticles and the optimization of orthopedic implants by advanced modification technologies |
| title_full_unstemmed | Potential antibacterial mechanism of silver nanoparticles and the optimization of orthopedic implants by advanced modification technologies |
| title_short | Potential antibacterial mechanism of silver nanoparticles and the optimization of orthopedic implants by advanced modification technologies |
| title_sort | potential antibacterial mechanism of silver nanoparticles and the optimization of orthopedic implants by advanced modification technologies |
| topic | Antibacterial mechanism Biocompatibility Osteogenic related cells Orthopedic implants Silver nanoparticles Surface modification |
| url | https://www.dovepress.com/potential-antibacterial-mechanism-of-silver-nanoparticles-and-the-opti-peer-reviewed-article-IJN |
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