TNFα Enhances Tamoxifen Sensitivity through Dissociation of ERα-p53-NCOR1 Complexes in ERα-Positive Breast Cancer

TNFα Enhances Tamoxifen Sensitivity through Dissociation of ERα-p53-NCOR1 Complexes in ERα-Positive Breast Cancer

Tamoxifen is widely used as a medication for estrogen receptor α (ERα)-positive breast cancer, despite the ~50% incidence of tamoxifen resistance. To overcome such resistance, combining tamoxifen with other agents is considered an effective approach. Here, through in vitro studies with ER-positive M...

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Bibliographic Details
Main Authors: Hyunhee Kim, Seung-Ho Park, Jangho Lee, Gi-Jun Sung, Ji-Hye Song, Sungmin Kwak, Ji-Hoon Jeong, Min-Jeong Kong, Jin-Taek Hwang, Hyo-Kyoung Choi, Kyung-Chul Choi
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Cancers
Subjects:
ER-positive breast cancer
tamoxifen resistance
TNFα
<i>NCOR1</i>
Online Access:https://www.mdpi.com/2072-6694/13/11/2601

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