Extracellular Vesicles in Chronic Demyelinating Diseases: Prospects in Treatment and Diagnosis of Autoimmune Neurological Disorders
Extracellular vesicles (EVs) represent membrane-enclosed structures that are likely to be secreted by all living cell types in the animal organism, including cells of peripheral (PNS) and central nervous systems (CNS). The ability to cross the blood-brain barrier (BBB) provides the possibility not o...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Life |
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| Online Access: | https://www.mdpi.com/2075-1729/12/11/1943 |
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| author | Leyla A. Ovchinnikova Arthur O. Zalevsky Yakov A. Lomakin |
| author_facet | Leyla A. Ovchinnikova Arthur O. Zalevsky Yakov A. Lomakin |
| author_sort | Leyla A. Ovchinnikova |
| collection | DOAJ |
| description | Extracellular vesicles (EVs) represent membrane-enclosed structures that are likely to be secreted by all living cell types in the animal organism, including cells of peripheral (PNS) and central nervous systems (CNS). The ability to cross the blood-brain barrier (BBB) provides the possibility not only for various EV-loaded molecules to be delivered to the brain tissues but also for the CNS-to-periphery transmission of these molecules. Since neural EVs transfer proteins and RNAs are both responsible for functional intercellular communication and involved in the pathogenesis of neurodegenerative diseases, they represent attractive diagnostic and therapeutic targets. Here, we discuss EVs’ role in maintaining the living organisms’ function and describe deviations in EVs’ structure and malfunctioning during various neurodegenerative diseases. |
| first_indexed | 2024-03-09T18:13:08Z |
| format | Article |
| id | doaj.art-c84c458b1fa44be696e35060c285193f |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-09T18:13:08Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-c84c458b1fa44be696e35060c285193f2023-11-24T08:58:26ZengMDPI AGLife2075-17292022-11-011211194310.3390/life12111943Extracellular Vesicles in Chronic Demyelinating Diseases: Prospects in Treatment and Diagnosis of Autoimmune Neurological DisordersLeyla A. Ovchinnikova0Arthur O. Zalevsky1Yakov A. Lomakin2Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, RAS, 117997 Moscow, RussiaShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, RAS, 117997 Moscow, RussiaShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, RAS, 117997 Moscow, RussiaExtracellular vesicles (EVs) represent membrane-enclosed structures that are likely to be secreted by all living cell types in the animal organism, including cells of peripheral (PNS) and central nervous systems (CNS). The ability to cross the blood-brain barrier (BBB) provides the possibility not only for various EV-loaded molecules to be delivered to the brain tissues but also for the CNS-to-periphery transmission of these molecules. Since neural EVs transfer proteins and RNAs are both responsible for functional intercellular communication and involved in the pathogenesis of neurodegenerative diseases, they represent attractive diagnostic and therapeutic targets. Here, we discuss EVs’ role in maintaining the living organisms’ function and describe deviations in EVs’ structure and malfunctioning during various neurodegenerative diseases.https://www.mdpi.com/2075-1729/12/11/1943extracellular vesicleexosomesmicrovesiclesEVsEAEbiomarker |
| spellingShingle | Leyla A. Ovchinnikova Arthur O. Zalevsky Yakov A. Lomakin Extracellular Vesicles in Chronic Demyelinating Diseases: Prospects in Treatment and Diagnosis of Autoimmune Neurological Disorders Life extracellular vesicle exosomes microvesicles EVs EAE biomarker |
| title | Extracellular Vesicles in Chronic Demyelinating Diseases: Prospects in Treatment and Diagnosis of Autoimmune Neurological Disorders |
| title_full | Extracellular Vesicles in Chronic Demyelinating Diseases: Prospects in Treatment and Diagnosis of Autoimmune Neurological Disorders |
| title_fullStr | Extracellular Vesicles in Chronic Demyelinating Diseases: Prospects in Treatment and Diagnosis of Autoimmune Neurological Disorders |
| title_full_unstemmed | Extracellular Vesicles in Chronic Demyelinating Diseases: Prospects in Treatment and Diagnosis of Autoimmune Neurological Disorders |
| title_short | Extracellular Vesicles in Chronic Demyelinating Diseases: Prospects in Treatment and Diagnosis of Autoimmune Neurological Disorders |
| title_sort | extracellular vesicles in chronic demyelinating diseases prospects in treatment and diagnosis of autoimmune neurological disorders |
| topic | extracellular vesicle exosomes microvesicles EVs EAE biomarker |
| url | https://www.mdpi.com/2075-1729/12/11/1943 |
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