Hypermethylation of the Promoter of miR-338-5p Mediates Aberrant Expression of ETS-1 and Is Correlated With Disease Severity Of Astrocytoma Patients

Hypermethylation of the Promoter of miR-338-5p Mediates Aberrant Expression of ETS-1 and Is Correlated With Disease Severity Of Astrocytoma Patients

The pro-oncogene ETS-1 (E26 transformation-specific sequence 1) is a key regulator of the proliferation and invasion of cancer cells. The present work examined the correlation of the aberrant expression of ETS-1 with histological or clinical classification of astrocytoma: grade I (pilocytic astrocyt...

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Bibliographic Details
Main Authors: Junping Wang, Cheng Huo, Jinzhu Yin, Lixia Tian, Lili Ma, Dongsheng Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-11-01
Series:Frontiers in Oncology
Subjects:
noncoding RNAs
microRNA-338-5p
E26 transformation-specific sequence 1
DNA methylation
astrocytoma
DNA methyltransferase 1
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.773644/full

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