Adipokines in young survivors of childhood acute lymphocytic leukemia revisited: beyond fat mass
Purpose This cross-sectional study evaluated the relationship between adipokines (leptin, adiponectin, visfatin, and resistin) and adiposity indexes regarding sex and cranial radiotherapy exposure among young acute lymphocytic leukemia survivors. Methods A multivariate analysis of covariance (MANCOV...
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| Format: | Article |
| Language: | English |
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Korean Society of Pediatric Endocrinology
2020-07-01
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| Series: | Annals of Pediatric Endocrinology & Metabolism |
| Subjects: | |
| Online Access: | http://e-apem.org/upload/pdf/apem-1938174-087.pdf |
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| author | Adriana Aparecida Siviero-Miachon Angela Maria Spinola-Castro Solange Andreoni Maria Lucia de Martino Lee Antonio Ramos Calixto Bruno Geloneze Gil Guerra-Junior |
| author_facet | Adriana Aparecida Siviero-Miachon Angela Maria Spinola-Castro Solange Andreoni Maria Lucia de Martino Lee Antonio Ramos Calixto Bruno Geloneze Gil Guerra-Junior |
| author_sort | Adriana Aparecida Siviero-Miachon |
| collection | DOAJ |
| description | Purpose This cross-sectional study evaluated the relationship between adipokines (leptin, adiponectin, visfatin, and resistin) and adiposity indexes regarding sex and cranial radiotherapy exposure among young acute lymphocytic leukemia survivors. Methods A multivariate analysis of covariance (MANCOVA) was used to evaluate the joint effect of sex, cranial radiotherapy, and body mass index (BMI) z-score (model 1) or fat mass index (FMI) (model 2) on adipokines. Results This study included 55 survivors of childhood acute lymphocytic leukemia between 15 and 23 years of age from both sexes (56.4% female); 43.6% of the sample had undergone cranial radiotherapy (18–24 Gy). The BMI z-score, the FMI, and sex (P<0.050 for all) influenced at least one adipokine, while cranial radiotherapy exposure was marginal in model 2. Parameter estimates from the MANCOVA's final model showed that the BMI z-score (β=-0.437, P=0.010) and the FMI (β=-0.209, P=0.004) negatively influenced adiponectin, while the FMI positively affected resistin (β=0.142, P=0.020). The relationship between leptin, visfatin, and the adiposity ndexes could not be established. In model 1, females presented with increased adiponectin (β=-1.014, P=0.011) and resistin (β=-1.067, P=0.002) levels; in model 2, female sex positively affected adiponectin (β=-1.515, P=0.001) and marginally influenced resistin (β=-0.707, P=0.054) levels. Cranial radiotherapy negatively determined visfatin levels in both final models (P<0.050). Conclusions Changes in body fat may be associated with adipose tissue dysfunction and should be carefully evaluated in survivors of acute lymphocytic leukemia, considering both sex and cranial radiotherapy exposure, to treat disorders that may possibly aggravate their risk for early cardiovascular disease. |
| first_indexed | 2024-12-10T07:27:42Z |
| format | Article |
| id | doaj.art-c84f965ee1384fe99461eaa10ec471c8 |
| institution | Directory Open Access Journal |
| issn | 2287-1012 2287-1292 |
| language | English |
| last_indexed | 2024-12-10T07:27:42Z |
| publishDate | 2020-07-01 |
| publisher | Korean Society of Pediatric Endocrinology |
| record_format | Article |
| series | Annals of Pediatric Endocrinology & Metabolism |
| spelling | doaj.art-c84f965ee1384fe99461eaa10ec471c82022-12-22T01:57:40ZengKorean Society of Pediatric EndocrinologyAnnals of Pediatric Endocrinology & Metabolism2287-10122287-12922020-07-0125317418110.6065/apem.1938174.087830Adipokines in young survivors of childhood acute lymphocytic leukemia revisited: beyond fat massAdriana Aparecida Siviero-Miachon0Angela Maria Spinola-Castro1Solange Andreoni2Maria Lucia de Martino Lee3Antonio Ramos Calixto4Bruno Geloneze5Gil Guerra-Junior6 Division of Pediatric Endocrinology, Federal University of Sao Paulo - UNIFESP/EPM, Sao Paulo, Brazil Division of Pediatric Endocrinology, Federal University of Sao Paulo - UNIFESP/EPM, Sao Paulo, Brazil Division of Biostatistics, Department of Preventive Medicine, UNIFESP/EPM, Sao Paulo, Brazil Division of Pediatric Oncology - Hospital Santa Marcelina/TUCCA, Sao Paulo, Brazil Laboratory of I nvestigation on Metabolism and Diabetes - LIMED, Faculty of Medical Sciences, State University of Campinas - UNICAMP, Campinas, Brazil Laboratory of I nvestigation on Metabolism and Diabetes - LIMED, Faculty of Medical Sciences, State University of Campinas - UNICAMP, Campinas, Brazil Division of Pediatric Endocrinology, Faculty of Medical Sciences, UNICAMP, Campinas, BrazilPurpose This cross-sectional study evaluated the relationship between adipokines (leptin, adiponectin, visfatin, and resistin) and adiposity indexes regarding sex and cranial radiotherapy exposure among young acute lymphocytic leukemia survivors. Methods A multivariate analysis of covariance (MANCOVA) was used to evaluate the joint effect of sex, cranial radiotherapy, and body mass index (BMI) z-score (model 1) or fat mass index (FMI) (model 2) on adipokines. Results This study included 55 survivors of childhood acute lymphocytic leukemia between 15 and 23 years of age from both sexes (56.4% female); 43.6% of the sample had undergone cranial radiotherapy (18–24 Gy). The BMI z-score, the FMI, and sex (P<0.050 for all) influenced at least one adipokine, while cranial radiotherapy exposure was marginal in model 2. Parameter estimates from the MANCOVA's final model showed that the BMI z-score (β=-0.437, P=0.010) and the FMI (β=-0.209, P=0.004) negatively influenced adiponectin, while the FMI positively affected resistin (β=0.142, P=0.020). The relationship between leptin, visfatin, and the adiposity ndexes could not be established. In model 1, females presented with increased adiponectin (β=-1.014, P=0.011) and resistin (β=-1.067, P=0.002) levels; in model 2, female sex positively affected adiponectin (β=-1.515, P=0.001) and marginally influenced resistin (β=-0.707, P=0.054) levels. Cranial radiotherapy negatively determined visfatin levels in both final models (P<0.050). Conclusions Changes in body fat may be associated with adipose tissue dysfunction and should be carefully evaluated in survivors of acute lymphocytic leukemia, considering both sex and cranial radiotherapy exposure, to treat disorders that may possibly aggravate their risk for early cardiovascular disease.http://e-apem.org/upload/pdf/apem-1938174-087.pdfprecursor cell lymphoblastic leukemia-lymphomaradiotherapycomplicationsbody weightadipokinesadipose tissue |
| spellingShingle | Adriana Aparecida Siviero-Miachon Angela Maria Spinola-Castro Solange Andreoni Maria Lucia de Martino Lee Antonio Ramos Calixto Bruno Geloneze Gil Guerra-Junior Adipokines in young survivors of childhood acute lymphocytic leukemia revisited: beyond fat mass Annals of Pediatric Endocrinology & Metabolism precursor cell lymphoblastic leukemia-lymphoma radiotherapy complications body weight adipokines adipose tissue |
| title | Adipokines in young survivors of childhood acute lymphocytic leukemia revisited: beyond fat mass |
| title_full | Adipokines in young survivors of childhood acute lymphocytic leukemia revisited: beyond fat mass |
| title_fullStr | Adipokines in young survivors of childhood acute lymphocytic leukemia revisited: beyond fat mass |
| title_full_unstemmed | Adipokines in young survivors of childhood acute lymphocytic leukemia revisited: beyond fat mass |
| title_short | Adipokines in young survivors of childhood acute lymphocytic leukemia revisited: beyond fat mass |
| title_sort | adipokines in young survivors of childhood acute lymphocytic leukemia revisited beyond fat mass |
| topic | precursor cell lymphoblastic leukemia-lymphoma radiotherapy complications body weight adipokines adipose tissue |
| url | http://e-apem.org/upload/pdf/apem-1938174-087.pdf |
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