The Cancer-Associated Genetic Variant Rs3903072 Modulates Immune Cells in the Tumor Microenvironment

The Cancer-Associated Genetic Variant Rs3903072 Modulates Immune Cells in the Tumor Microenvironment

Genome-wide association studies (GWAS) have hitherto identified several germline variants associated with cancer susceptibility, but the molecular functions of these risk modulators remain largely uncharacterized. Recent studies have begun to uncover the regulatory potential of noncoding GWAS SNPs u...

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Bibliographic Details
Main Authors: Yi Zhang, Mohith Manjunath, Jialu Yan, Brittany A. Baur, Shilu Zhang, Sushmita Roy, Jun S. Song
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Genetics
Subjects:
noncoding variant
GWAS
breast cancer
functional characterization
immune cells
tumor microenvironment
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2019.00754/full

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