Epidemiology of pneumonia in hospitalized adults ≥18 years old in four districts of Ulaanbaatar, Mongolia, 2015–2019
Summary: Background: Community-acquired pneumonia is a leading cause of morbidity and mortality among children and adults worldwide. Adult pneumonia surveillance remains limited in many low- and middle-income settings, resulting in the disease burden being largely unknown. Methods: A retrospective...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-01-01
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| Series: | The Lancet Regional Health. Western Pacific |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666606522002061 |
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| author | Kirsten Fagerli Mukhchuluun Ulziibayar Bujinlkham Suuri Dashtseren Luvsantseren Dorj Narangerel Purevsuren Batsaikhan Bilegtsaikhan Tsolmon Bradford D. Gessner Eileen M. Dunne Anneke C. Grobler Cattram D. Nguyen Tuya Mungun E. Kim Mulholland Claire von Mollendorf |
| author_facet | Kirsten Fagerli Mukhchuluun Ulziibayar Bujinlkham Suuri Dashtseren Luvsantseren Dorj Narangerel Purevsuren Batsaikhan Bilegtsaikhan Tsolmon Bradford D. Gessner Eileen M. Dunne Anneke C. Grobler Cattram D. Nguyen Tuya Mungun E. Kim Mulholland Claire von Mollendorf |
| author_sort | Kirsten Fagerli |
| collection | DOAJ |
| description | Summary: Background: Community-acquired pneumonia is a leading cause of morbidity and mortality among children and adults worldwide. Adult pneumonia surveillance remains limited in many low- and middle-income settings, resulting in the disease burden being largely unknown. Methods: A retrospective cohort study was conducted by reviewing medical charts for respiratory admissions at four district hospitals in Ulaanbaatar during January 2015–February 2019. Characteristics of community-acquired pneumonia cases were summarized by disease severity and age. To explore factors associated with severe pneumonia, we ran univariable and age-adjusted logistic regression models. Incidence rates were calculated using population denominators. Results: In total, 4290 respiratory admissions met the case definition for clinical pneumonia, including 430 admissions of severe pneumonia. The highest proportion of severe pneumonia admissions occurred in adults >65 years (37.4%). After adjusting for age, there were increased odds of severe pneumonia in males (adjusted odds ratio [aOR]: 1.63; 95% confidence interval [CI]: 1.33-2.00) and those with ≥1 underlying medical condition (aOR: 1.46; 95% CI: 1.14-1.87). The incidence of hospitalized pneumonia in adults ≥18 years increased from 13.49 (95% CI: 12.58-14.44) in 2015 to 17.65 (95% CI: 16.63-18.71) in 2018 per 10,000 population. The incidence of severe pneumonia was highest in adults >65 years, ranging from 9.29 (95% CI: 6.17-13.43) in 2015 to 12.69 (95% CI: 9.22-17.04) in 2018 per 10,000 population. Interpretations: Vaccination and other strategies to reduce the risk of pneumonia, particularly among older adults and those with underlying medical conditions, should be prioritized. Funding: Pfizer clinical research collaboration agreement (contract number: WI236621). |
| first_indexed | 2024-04-12T07:02:59Z |
| format | Article |
| id | doaj.art-c8518f251d0d4206aa13777730aabc96 |
| institution | Directory Open Access Journal |
| issn | 2666-6065 |
| language | English |
| last_indexed | 2024-04-12T07:02:59Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | The Lancet Regional Health. Western Pacific |
| spelling | doaj.art-c8518f251d0d4206aa13777730aabc962022-12-22T03:42:57ZengElsevierThe Lancet Regional Health. Western Pacific2666-60652023-01-0130100591Epidemiology of pneumonia in hospitalized adults ≥18 years old in four districts of Ulaanbaatar, Mongolia, 2015–2019Kirsten Fagerli0Mukhchuluun Ulziibayar1Bujinlkham Suuri2Dashtseren Luvsantseren3Dorj Narangerel4Purevsuren Batsaikhan5Bilegtsaikhan Tsolmon6Bradford D. Gessner7Eileen M. Dunne8Anneke C. Grobler9Cattram D. Nguyen10Tuya Mungun11E. Kim Mulholland12Claire von Mollendorf13University of Melbourne, Melbourne, Australia; Murdoch Children's Research Institute, Melbourne, Australia; Corresponding author at: Murdoch Children's Research Institute, The Royal Children's Hospital, 50 Flemington Road, Parkville, Victoria 3052 Australia.The National Centre for Communicable Disease, Ministry of Health, Bayanzurkh distrct, Horoo 14, 13th district, Nam Yan Ju Street, Ulaanbaatar 210648, MongoliaThe National Centre for Communicable Disease, Ministry of Health, Bayanzurkh distrct, Horoo 14, 13th district, Nam Yan Ju Street, Ulaanbaatar 210648, MongoliaThe National Centre for Communicable Disease, Ministry of Health, Bayanzurkh distrct, Horoo 14, 13th district, Nam Yan Ju Street, Ulaanbaatar 210648, MongoliaMinistry of Health, WW8C+79C, Olympic Street, Ulaanbaatar, MongoliaThe National Centre for Communicable Disease, Ministry of Health, Bayanzurkh distrct, Horoo 14, 13th district, Nam Yan Ju Street, Ulaanbaatar 210648, MongoliaThe National Centre for Communicable Disease, Ministry of Health, Bayanzurkh distrct, Horoo 14, 13th district, Nam Yan Ju Street, Ulaanbaatar 210648, MongoliaPfizer Inc., 500 Arcola Rd., Collegeville, PA 19426, USAPfizer Inc., 500 Arcola Rd., Collegeville, PA 19426, USAUniversity of Melbourne, Melbourne, Australia; Murdoch Children's Research Institute, Melbourne, AustraliaUniversity of Melbourne, Melbourne, Australia; Murdoch Children's Research Institute, Melbourne, AustraliaThe National Centre for Communicable Disease, Ministry of Health, Bayanzurkh distrct, Horoo 14, 13th district, Nam Yan Ju Street, Ulaanbaatar 210648, MongoliaUniversity of Melbourne, Melbourne, Australia; Murdoch Children's Research Institute, Melbourne, Australia; London School of Hygiene and Tropical Medicine, London, UKUniversity of Melbourne, Melbourne, Australia; Murdoch Children's Research Institute, Melbourne, AustraliaSummary: Background: Community-acquired pneumonia is a leading cause of morbidity and mortality among children and adults worldwide. Adult pneumonia surveillance remains limited in many low- and middle-income settings, resulting in the disease burden being largely unknown. Methods: A retrospective cohort study was conducted by reviewing medical charts for respiratory admissions at four district hospitals in Ulaanbaatar during January 2015–February 2019. Characteristics of community-acquired pneumonia cases were summarized by disease severity and age. To explore factors associated with severe pneumonia, we ran univariable and age-adjusted logistic regression models. Incidence rates were calculated using population denominators. Results: In total, 4290 respiratory admissions met the case definition for clinical pneumonia, including 430 admissions of severe pneumonia. The highest proportion of severe pneumonia admissions occurred in adults >65 years (37.4%). After adjusting for age, there were increased odds of severe pneumonia in males (adjusted odds ratio [aOR]: 1.63; 95% confidence interval [CI]: 1.33-2.00) and those with ≥1 underlying medical condition (aOR: 1.46; 95% CI: 1.14-1.87). The incidence of hospitalized pneumonia in adults ≥18 years increased from 13.49 (95% CI: 12.58-14.44) in 2015 to 17.65 (95% CI: 16.63-18.71) in 2018 per 10,000 population. The incidence of severe pneumonia was highest in adults >65 years, ranging from 9.29 (95% CI: 6.17-13.43) in 2015 to 12.69 (95% CI: 9.22-17.04) in 2018 per 10,000 population. Interpretations: Vaccination and other strategies to reduce the risk of pneumonia, particularly among older adults and those with underlying medical conditions, should be prioritized. Funding: Pfizer clinical research collaboration agreement (contract number: WI236621).http://www.sciencedirect.com/science/article/pii/S2666606522002061PneumoniaHospitalizationAdult pneumoniaDisease incidenceMongolia |
| spellingShingle | Kirsten Fagerli Mukhchuluun Ulziibayar Bujinlkham Suuri Dashtseren Luvsantseren Dorj Narangerel Purevsuren Batsaikhan Bilegtsaikhan Tsolmon Bradford D. Gessner Eileen M. Dunne Anneke C. Grobler Cattram D. Nguyen Tuya Mungun E. Kim Mulholland Claire von Mollendorf Epidemiology of pneumonia in hospitalized adults ≥18 years old in four districts of Ulaanbaatar, Mongolia, 2015–2019 The Lancet Regional Health. Western Pacific Pneumonia Hospitalization Adult pneumonia Disease incidence Mongolia |
| title | Epidemiology of pneumonia in hospitalized adults ≥18 years old in four districts of Ulaanbaatar, Mongolia, 2015–2019 |
| title_full | Epidemiology of pneumonia in hospitalized adults ≥18 years old in four districts of Ulaanbaatar, Mongolia, 2015–2019 |
| title_fullStr | Epidemiology of pneumonia in hospitalized adults ≥18 years old in four districts of Ulaanbaatar, Mongolia, 2015–2019 |
| title_full_unstemmed | Epidemiology of pneumonia in hospitalized adults ≥18 years old in four districts of Ulaanbaatar, Mongolia, 2015–2019 |
| title_short | Epidemiology of pneumonia in hospitalized adults ≥18 years old in four districts of Ulaanbaatar, Mongolia, 2015–2019 |
| title_sort | epidemiology of pneumonia in hospitalized adults ≥18 years old in four districts of ulaanbaatar mongolia 2015 2019 |
| topic | Pneumonia Hospitalization Adult pneumonia Disease incidence Mongolia |
| url | http://www.sciencedirect.com/science/article/pii/S2666606522002061 |
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