A Gadolinium(III) Complex Based on the Thymine Nucleobase with Properties Suitable for Magnetic Resonance Imaging
The paramagnetic gadolinium(III) ion is used as contrast agent in magnetic resonance (MR) imaging to improve the lesion detection and characterization. It generates a signal by changing the relaxivity of protons from associated water molecules and creates a clearer physical distinction between the m...
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MDPI AG
2021-04-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/9/4586 |
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| author | Marta Orts-Arroyo Amadeo Ten-Esteve Sonia Ginés-Cárdenas Isabel Castro Luis Martí-Bonmatí José Martínez-Lillo |
| author_facet | Marta Orts-Arroyo Amadeo Ten-Esteve Sonia Ginés-Cárdenas Isabel Castro Luis Martí-Bonmatí José Martínez-Lillo |
| author_sort | Marta Orts-Arroyo |
| collection | DOAJ |
| description | The paramagnetic gadolinium(III) ion is used as contrast agent in magnetic resonance (MR) imaging to improve the lesion detection and characterization. It generates a signal by changing the relaxivity of protons from associated water molecules and creates a clearer physical distinction between the molecule and the surrounding tissues. New gadolinium-based contrast agents displaying larger relaxivity values and specifically targeted might provide higher resolution and better functional images. We have synthesized the gadolinium(III) complex of formula [Gd(thy)<sub>2</sub>(H<sub>2</sub>O)<sub>6</sub>](ClO<sub>4</sub>)<sub>3</sub>·2H<sub>2</sub>O (<b>1</b>) [thy = 5-methyl-1H-pyrimidine-2,4-dione or thymine], which is the first reported compound based on gadolinium and thymine nucleobase. <b>1</b> has been characterized through UV-vis, IR, SEM-EDAX, and single-crystal X-ray diffraction techniques, and its magnetic and relaxometric properties have been investigated by means of SQUID magnetometer and MR imaging phantom studies, respectively. On the basis of its high relaxivity values, this gadolinium(III) complex can be considered a suitable candidate for contrast-enhanced magnetic resonance imaging. |
| first_indexed | 2024-03-10T11:55:24Z |
| format | Article |
| id | doaj.art-c852330724d444128a94ed9ed0fab570 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T11:55:24Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-c852330724d444128a94ed9ed0fab5702023-11-21T17:24:10ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-04-01229458610.3390/ijms22094586A Gadolinium(III) Complex Based on the Thymine Nucleobase with Properties Suitable for Magnetic Resonance ImagingMarta Orts-Arroyo0Amadeo Ten-Esteve1Sonia Ginés-Cárdenas2Isabel Castro3Luis Martí-Bonmatí4José Martínez-Lillo5Instituto de Ciencia Molecular (ICMol), Universitat de València, c/Catedrático José Beltrán 2, Paterna, 46980 Valencia, SpainRadiology Department and Biomedical Imaging Research Group (GIBI230), La Fe University and Polytechnic Hospital and La Fe Health Research Institute, 46026 Valencia, SpainRadiology Department and Biomedical Imaging Research Group (GIBI230), La Fe University and Polytechnic Hospital and La Fe Health Research Institute, 46026 Valencia, SpainInstituto de Ciencia Molecular (ICMol), Universitat de València, c/Catedrático José Beltrán 2, Paterna, 46980 Valencia, SpainRadiology Department and Biomedical Imaging Research Group (GIBI230), La Fe University and Polytechnic Hospital and La Fe Health Research Institute, 46026 Valencia, SpainInstituto de Ciencia Molecular (ICMol), Universitat de València, c/Catedrático José Beltrán 2, Paterna, 46980 Valencia, SpainThe paramagnetic gadolinium(III) ion is used as contrast agent in magnetic resonance (MR) imaging to improve the lesion detection and characterization. It generates a signal by changing the relaxivity of protons from associated water molecules and creates a clearer physical distinction between the molecule and the surrounding tissues. New gadolinium-based contrast agents displaying larger relaxivity values and specifically targeted might provide higher resolution and better functional images. We have synthesized the gadolinium(III) complex of formula [Gd(thy)<sub>2</sub>(H<sub>2</sub>O)<sub>6</sub>](ClO<sub>4</sub>)<sub>3</sub>·2H<sub>2</sub>O (<b>1</b>) [thy = 5-methyl-1H-pyrimidine-2,4-dione or thymine], which is the first reported compound based on gadolinium and thymine nucleobase. <b>1</b> has been characterized through UV-vis, IR, SEM-EDAX, and single-crystal X-ray diffraction techniques, and its magnetic and relaxometric properties have been investigated by means of SQUID magnetometer and MR imaging phantom studies, respectively. On the basis of its high relaxivity values, this gadolinium(III) complex can be considered a suitable candidate for contrast-enhanced magnetic resonance imaging.https://www.mdpi.com/1422-0067/22/9/4586thyminegadoliniumcontrast agentmagnetic resonancemetal complexescrystal structure |
| spellingShingle | Marta Orts-Arroyo Amadeo Ten-Esteve Sonia Ginés-Cárdenas Isabel Castro Luis Martí-Bonmatí José Martínez-Lillo A Gadolinium(III) Complex Based on the Thymine Nucleobase with Properties Suitable for Magnetic Resonance Imaging International Journal of Molecular Sciences thymine gadolinium contrast agent magnetic resonance metal complexes crystal structure |
| title | A Gadolinium(III) Complex Based on the Thymine Nucleobase with Properties Suitable for Magnetic Resonance Imaging |
| title_full | A Gadolinium(III) Complex Based on the Thymine Nucleobase with Properties Suitable for Magnetic Resonance Imaging |
| title_fullStr | A Gadolinium(III) Complex Based on the Thymine Nucleobase with Properties Suitable for Magnetic Resonance Imaging |
| title_full_unstemmed | A Gadolinium(III) Complex Based on the Thymine Nucleobase with Properties Suitable for Magnetic Resonance Imaging |
| title_short | A Gadolinium(III) Complex Based on the Thymine Nucleobase with Properties Suitable for Magnetic Resonance Imaging |
| title_sort | gadolinium iii complex based on the thymine nucleobase with properties suitable for magnetic resonance imaging |
| topic | thymine gadolinium contrast agent magnetic resonance metal complexes crystal structure |
| url | https://www.mdpi.com/1422-0067/22/9/4586 |
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