Primary immune thrombocytopenia in children
Primary immune thrombocytopenia (ITP) is usually a benign and self-limiting disease in children. Due to the complex pathogenesis involving different immunological processes, its course may be unpredictable. The goal of therapy is to prevent severe, dangerous bleeding, especially intracranial bleedin...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Termedia Publishing House
2021-03-01
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| Series: | Pediatria Polska |
| Subjects: | |
| Online Access: | https://www.termedia.pl/Primary-immune-thrombocytopenia-in-children,127,43672,1,1.html |
| _version_ | 1797215315792232448 |
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| author | Agnieszka Książek Tomasz Szczepański |
| author_facet | Agnieszka Książek Tomasz Szczepański |
| author_sort | Agnieszka Książek |
| collection | DOAJ |
| description | Primary immune thrombocytopenia (ITP) is usually a benign and self-limiting disease in children. Due to the complex pathogenesis involving different immunological processes, its course may be unpredictable. The goal of therapy is to prevent severe, dangerous bleeding, especially intracranial bleeding. In addition to purpura, i.e. ecchymoses and bruises on the skin, mucosal bleeding may occur, e.g. from nose, gums, excessive menstrual bleeding, as well as severe bleeding from the gastrointestinal or urinary tract. First-line therapy relies on glucocorticoids (GKS) or intravenous immunoglobulins (IVIgG). The next stage of treatment is the inclusion of other immunosuppressive drugs or cytotoxic drugs. The introduction of thrombopoietin receptor agonists (TPO-RAs) for the treatment of this disease has been the biggest progress over the past 20 years. TPO-RAs are treatment of choice for chronic ITP. Splenectomy is now reserved only for children with chronic ITP resistant to thrombopoietin receptor agonists.. |
| first_indexed | 2024-04-24T11:28:07Z |
| format | Article |
| id | doaj.art-c8524d124c524b3a99ab8339adedf286 |
| institution | Directory Open Access Journal |
| issn | 0031-3939 2300-8660 |
| language | English |
| last_indexed | 2024-04-24T11:28:07Z |
| publishDate | 2021-03-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| series | Pediatria Polska |
| spelling | doaj.art-c8524d124c524b3a99ab8339adedf2862024-04-10T12:46:11ZengTermedia Publishing HousePediatria Polska0031-39392300-86602021-03-01961535910.5114/polp.2021.10482943672Primary immune thrombocytopenia in childrenAgnieszka KsiążekTomasz SzczepańskiPrimary immune thrombocytopenia (ITP) is usually a benign and self-limiting disease in children. Due to the complex pathogenesis involving different immunological processes, its course may be unpredictable. The goal of therapy is to prevent severe, dangerous bleeding, especially intracranial bleeding. In addition to purpura, i.e. ecchymoses and bruises on the skin, mucosal bleeding may occur, e.g. from nose, gums, excessive menstrual bleeding, as well as severe bleeding from the gastrointestinal or urinary tract. First-line therapy relies on glucocorticoids (GKS) or intravenous immunoglobulins (IVIgG). The next stage of treatment is the inclusion of other immunosuppressive drugs or cytotoxic drugs. The introduction of thrombopoietin receptor agonists (TPO-RAs) for the treatment of this disease has been the biggest progress over the past 20 years. TPO-RAs are treatment of choice for chronic ITP. Splenectomy is now reserved only for children with chronic ITP resistant to thrombopoietin receptor agonists..https://www.termedia.pl/Primary-immune-thrombocytopenia-in-children,127,43672,1,1.htmlprimary immune thrombocytopenia children treatment. |
| spellingShingle | Agnieszka Książek Tomasz Szczepański Primary immune thrombocytopenia in children Pediatria Polska primary immune thrombocytopenia children treatment. |
| title | Primary immune thrombocytopenia in children |
| title_full | Primary immune thrombocytopenia in children |
| title_fullStr | Primary immune thrombocytopenia in children |
| title_full_unstemmed | Primary immune thrombocytopenia in children |
| title_short | Primary immune thrombocytopenia in children |
| title_sort | primary immune thrombocytopenia in children |
| topic | primary immune thrombocytopenia children treatment. |
| url | https://www.termedia.pl/Primary-immune-thrombocytopenia-in-children,127,43672,1,1.html |
| work_keys_str_mv | AT agnieszkaksiazek primaryimmunethrombocytopeniainchildren AT tomaszszczepanski primaryimmunethrombocytopeniainchildren |