Pathophysiology, Diagnosis and Treatment of Immune Thrombocytopenia
Immune thrombocytopenia (ITP) is an acquired disorder characterized by isolated thrombocytopenia with a peripheral blood count < 100.000/ mm3 in the absence of any obvious initiating or underlying causes, by antibody mediated destruction of platelets and suppression of megakaryocyte and platelet...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
University Library System, University of Pittsburgh
2017-03-01
|
| Series: | International Journal of Medical Students |
| Subjects: | |
| Online Access: | http://ijms.info/IJMS/article/view/171 |
| _version_ | 1827838504937193472 |
|---|---|
| author | Mihnea-Alexandru Găman Amelia Maria Găman |
| author_facet | Mihnea-Alexandru Găman Amelia Maria Găman |
| author_sort | Mihnea-Alexandru Găman |
| collection | DOAJ |
| description | Immune thrombocytopenia (ITP) is an acquired disorder characterized by isolated thrombocytopenia with a peripheral blood count < 100.000/ mm3 in the absence of any obvious initiating or underlying causes, by antibody mediated destruction of platelets and suppression of megakaryocyte and platelet production on the basis of immune deregulation. ITP is idiopathic (primary) in 80% of cases and secondary to several associated disorders in 20% of cases. A diagnosis of exclusion, based on patient history, physical examination, complete blood count and examination of the peripheral blood smear, is used for ITP. The treatment of ITP is indicated in adult patients with platelet counts below 20.000-30.000/ mm3, with bleedings or risk for bleeding. First line therapy is represented by corticosteroids, intravenous immunoglobulins and intravenous anti-RhD. Second-line treatment is represented by: splenectomy, inhibition of the monocytic phagocytic system therapy, immunosupressive therapy, anabolic steroids, anti-CD20 therapy, and thrombopoietin receptor agonists. |
| first_indexed | 2024-03-12T07:06:32Z |
| format | Article |
| id | doaj.art-c8538d82d73f4169914d144948d3dc04 |
| institution | Directory Open Access Journal |
| issn | 2076-6327 |
| language | English |
| last_indexed | 2024-03-12T07:06:32Z |
| publishDate | 2017-03-01 |
| publisher | University Library System, University of Pittsburgh |
| record_format | Article |
| series | International Journal of Medical Students |
| spelling | doaj.art-c8538d82d73f4169914d144948d3dc042023-09-02T23:24:45ZengUniversity Library System, University of PittsburghInternational Journal of Medical Students2076-63272017-03-0151323610.5195/ijms.2017.171171Pathophysiology, Diagnosis and Treatment of Immune ThrombocytopeniaMihnea-Alexandru Găman0Amelia Maria Găman1Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania.Department of Pathophysiology, University of Medicine and Pharmacy of Craiova & Clinic of Hematology, Filantropia City Hospital, Craiova, RomaniaImmune thrombocytopenia (ITP) is an acquired disorder characterized by isolated thrombocytopenia with a peripheral blood count < 100.000/ mm3 in the absence of any obvious initiating or underlying causes, by antibody mediated destruction of platelets and suppression of megakaryocyte and platelet production on the basis of immune deregulation. ITP is idiopathic (primary) in 80% of cases and secondary to several associated disorders in 20% of cases. A diagnosis of exclusion, based on patient history, physical examination, complete blood count and examination of the peripheral blood smear, is used for ITP. The treatment of ITP is indicated in adult patients with platelet counts below 20.000-30.000/ mm3, with bleedings or risk for bleeding. First line therapy is represented by corticosteroids, intravenous immunoglobulins and intravenous anti-RhD. Second-line treatment is represented by: splenectomy, inhibition of the monocytic phagocytic system therapy, immunosupressive therapy, anabolic steroids, anti-CD20 therapy, and thrombopoietin receptor agonists.http://ijms.info/IJMS/article/view/171primary immune thrombocytopenia, itpguidelinesthrombopoietin receptor agonistssplenectomyimmune thrombocytopenic purpura |
| spellingShingle | Mihnea-Alexandru Găman Amelia Maria Găman Pathophysiology, Diagnosis and Treatment of Immune Thrombocytopenia International Journal of Medical Students primary immune thrombocytopenia, itp guidelines thrombopoietin receptor agonists splenectomy immune thrombocytopenic purpura |
| title | Pathophysiology, Diagnosis and Treatment of Immune Thrombocytopenia |
| title_full | Pathophysiology, Diagnosis and Treatment of Immune Thrombocytopenia |
| title_fullStr | Pathophysiology, Diagnosis and Treatment of Immune Thrombocytopenia |
| title_full_unstemmed | Pathophysiology, Diagnosis and Treatment of Immune Thrombocytopenia |
| title_short | Pathophysiology, Diagnosis and Treatment of Immune Thrombocytopenia |
| title_sort | pathophysiology diagnosis and treatment of immune thrombocytopenia |
| topic | primary immune thrombocytopenia, itp guidelines thrombopoietin receptor agonists splenectomy immune thrombocytopenic purpura |
| url | http://ijms.info/IJMS/article/view/171 |
| work_keys_str_mv | AT mihneaalexandrugaman pathophysiologydiagnosisandtreatmentofimmunethrombocytopenia AT ameliamariagaman pathophysiologydiagnosisandtreatmentofimmunethrombocytopenia |