Decreased Serum Level of Interleukin-19 in Iranian Patients with Breast Cancer
Background: Interleukin-19, a member of the interleukin-10 family of cytokines, contributes to breast cancer pathogenesis. High interleukin-19 expression in breast tumor tissues is associated with poor clinical outcome. This study aimed to assess the changes in serum level of interleukin-19 in br...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Shiraz University of Medical Sciences
2015-10-01
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| Series: | Middle East Journal of Cancer |
| Subjects: | |
| Online Access: | http://mejc.sums.ac.ir/index.php/mejc/article/view/338/225 |
| _version_ | 1818642702215938048 |
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| author | Fereshteh Mehdipour Mahyar Malekzadeh Abdolrasoul Talei Abbas Ghaderi |
| author_facet | Fereshteh Mehdipour Mahyar Malekzadeh Abdolrasoul Talei Abbas Ghaderi |
| author_sort | Fereshteh Mehdipour |
| collection | DOAJ |
| description | Background: Interleukin-19, a member of the interleukin-10 family of cytokines,
contributes to breast cancer pathogenesis. High interleukin-19 expression in breast
tumor tissues is associated with poor clinical outcome. This study aimed to assess
the changes in serum level of interleukin-19 in breast cancer patients in comparison
with normal women and its association with the clinicopathological parameters of
this disease.
Methods: Enzyme-linked immunosorbent assay was used to analyze serum
levels of interleukin-19 in 116 women with breast cancer before chemotherapy or
radiotherapy, and in 60 healthy age-matched women without any acute or chronic
diseases or family history of cancer.
Results: There were significantly lower serum interleukin-19 levels in breast cancer
patients (median: 27.3 pg/ml; range: 10.5-2443.6 pg/ml) compared to healthy
controls (median: 35.1 pg/ml; range: 10.9-13676.6 pg/ml; P<0.01). Compared to the
healthy control group, the decrease in serum interleukin-19 concentration was seen
in all breast cancer stages. However the decrease was only significant for stage III
(P=0.02). We found no significant association between serum interleukin-19 levels
and stage, grade, lymph node involvement or other clinicopathological variables of
the disease. However, when compared to the healthy control group, we found
significantly decreased serum interleukin-19 levels in patients with involved lymph
nodes (P<0.01) or tumor size greater than 2 cm (P=0.01).
Conclusion: There were significantly decreased interleukin-19 levels in breast
cancer patients compared to the healthy control group. We observed no association
between serum interleukin-19 levels and clinicopathological parameters in breast
cancer patients. |
| first_indexed | 2024-12-16T23:47:15Z |
| format | Article |
| id | doaj.art-c85446108d054d38b1ff860299255abc |
| institution | Directory Open Access Journal |
| issn | 2008-6709 2008-6687 |
| language | English |
| last_indexed | 2024-12-16T23:47:15Z |
| publishDate | 2015-10-01 |
| publisher | Shiraz University of Medical Sciences |
| record_format | Article |
| series | Middle East Journal of Cancer |
| spelling | doaj.art-c85446108d054d38b1ff860299255abc2022-12-21T22:11:28ZengShiraz University of Medical SciencesMiddle East Journal of Cancer2008-67092008-66872015-10-0164203209Decreased Serum Level of Interleukin-19 in Iranian Patients with Breast CancerFereshteh Mehdipour0Mahyar Malekzadeh1Abdolrasoul Talei2Abbas Ghaderi3Shiraz Institute for Cancer Research, School of Medicine, Shiraz University of Medical Sciences, Shiraz, IranShiraz Institute for Cancer Research, School of Medicine, Shiraz University of Medical Sciences, Shiraz, IranDepartment of Surgery, School of Medicine, Shiraz University of Medical Sciences, Shiraz, IranShiraz Institute for Cancer Research, School of Medicine, Shiraz University of Medical Sciences, Shiraz, IranBackground: Interleukin-19, a member of the interleukin-10 family of cytokines, contributes to breast cancer pathogenesis. High interleukin-19 expression in breast tumor tissues is associated with poor clinical outcome. This study aimed to assess the changes in serum level of interleukin-19 in breast cancer patients in comparison with normal women and its association with the clinicopathological parameters of this disease. Methods: Enzyme-linked immunosorbent assay was used to analyze serum levels of interleukin-19 in 116 women with breast cancer before chemotherapy or radiotherapy, and in 60 healthy age-matched women without any acute or chronic diseases or family history of cancer. Results: There were significantly lower serum interleukin-19 levels in breast cancer patients (median: 27.3 pg/ml; range: 10.5-2443.6 pg/ml) compared to healthy controls (median: 35.1 pg/ml; range: 10.9-13676.6 pg/ml; P<0.01). Compared to the healthy control group, the decrease in serum interleukin-19 concentration was seen in all breast cancer stages. However the decrease was only significant for stage III (P=0.02). We found no significant association between serum interleukin-19 levels and stage, grade, lymph node involvement or other clinicopathological variables of the disease. However, when compared to the healthy control group, we found significantly decreased serum interleukin-19 levels in patients with involved lymph nodes (P<0.01) or tumor size greater than 2 cm (P=0.01). Conclusion: There were significantly decreased interleukin-19 levels in breast cancer patients compared to the healthy control group. We observed no association between serum interleukin-19 levels and clinicopathological parameters in breast cancer patients.http://mejc.sums.ac.ir/index.php/mejc/article/view/338/225Serum levelInterleukin-19Breast cancer |
| spellingShingle | Fereshteh Mehdipour Mahyar Malekzadeh Abdolrasoul Talei Abbas Ghaderi Decreased Serum Level of Interleukin-19 in Iranian Patients with Breast Cancer Middle East Journal of Cancer Serum level Interleukin-19 Breast cancer |
| title | Decreased Serum Level of Interleukin-19 in Iranian Patients with Breast Cancer |
| title_full | Decreased Serum Level of Interleukin-19 in Iranian Patients with Breast Cancer |
| title_fullStr | Decreased Serum Level of Interleukin-19 in Iranian Patients with Breast Cancer |
| title_full_unstemmed | Decreased Serum Level of Interleukin-19 in Iranian Patients with Breast Cancer |
| title_short | Decreased Serum Level of Interleukin-19 in Iranian Patients with Breast Cancer |
| title_sort | decreased serum level of interleukin 19 in iranian patients with breast cancer |
| topic | Serum level Interleukin-19 Breast cancer |
| url | http://mejc.sums.ac.ir/index.php/mejc/article/view/338/225 |
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