Plasma Metabolomics Analysis of Polyvinyl Chloride Workers Identifies Altered Processes and Candidate Biomarkers for Hepatic Hemangiosarcoma and Its Development

Plasma Metabolomics Analysis of Polyvinyl Chloride Workers Identifies Altered Processes and Candidate Biomarkers for Hepatic Hemangiosarcoma and Its Development

Background: High-level occupational vinyl chloride (VC) exposures have been associated with hepatic hemangiosarcoma, which typically develops following a long latency period. Although VC is genotoxic, a more comprehensive mode of action has not been determined and diagnostic biomarkers have not been...

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Bibliographic Details
Main Authors: John J. Guardiola, Josiah E. Hardesty, Juliane I. Beier, Russell A. Prough, Craig J. McClain, Matthew C. Cave
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:International Journal of Molecular Sciences
Subjects:
angiosarcoma
vinyl chloride
PVC
liver cancer
Online Access:https://www.mdpi.com/1422-0067/22/10/5093

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