Mismatch negativity (MMN) latency as a biomarker of amnestic mild cognitive impairment in Chinese rural elders
The aim was to evaluate the Mismatch Negativity (MMN) component, a correlate of the automatic detection of changes in the acoustic environment, in healthy adults and adults with aMCI. 43 mild amnestic cognitive impairment (aMCI) subjects and 43 healthy Chinese older adults were arranged into experim...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2015-03-01
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| Series: | Frontiers in Aging Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnagi.2015.00022/full |
| _version_ | 1819267127284072448 |
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| author | Li li Ji Yuan yuan Zhang Lane eZhang Bing eHe Guo Hua Lu |
| author_facet | Li li Ji Yuan yuan Zhang Lane eZhang Bing eHe Guo Hua Lu |
| author_sort | Li li Ji |
| collection | DOAJ |
| description | The aim was to evaluate the Mismatch Negativity (MMN) component, a correlate of the automatic detection of changes in the acoustic environment, in healthy adults and adults with aMCI. 43 mild amnestic cognitive impairment (aMCI) subjects and 43 healthy Chinese older adults were arranged into experimental group and control group respectively. Their MMN amplitude and latency were measured at the FZ, FCZ and CZ electrode sites under a passive auditory oddball task. The results showed that the latencies obtained from the FZ, FCZ and CZ electrode sites were significantly longer in the aMCI adults than in the control adults (P<0.01) while there were no significant differences in MMN amplitude between two groups(P＞0.05). The MMN latency was found to be a sensitive and specific biomarker of aMCI. |
| first_indexed | 2024-12-23T21:12:13Z |
| format | Article |
| id | doaj.art-c85a7b44c1fd46d3a8b6905e4e89ffa4 |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-12-23T21:12:13Z |
| publishDate | 2015-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-c85a7b44c1fd46d3a8b6905e4e89ffa42022-12-21T17:31:01ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652015-03-01710.3389/fnagi.2015.00022134399Mismatch negativity (MMN) latency as a biomarker of amnestic mild cognitive impairment in Chinese rural eldersLi li Ji0Yuan yuan Zhang1Lane eZhang2Bing eHe3Guo Hua Lu4Weifang Medical UniversityWeifang Medical UniversityWeifang Medical UniversityWeifang Medical UniversityWeifang Medical UniversityThe aim was to evaluate the Mismatch Negativity (MMN) component, a correlate of the automatic detection of changes in the acoustic environment, in healthy adults and adults with aMCI. 43 mild amnestic cognitive impairment (aMCI) subjects and 43 healthy Chinese older adults were arranged into experimental group and control group respectively. Their MMN amplitude and latency were measured at the FZ, FCZ and CZ electrode sites under a passive auditory oddball task. The results showed that the latencies obtained from the FZ, FCZ and CZ electrode sites were significantly longer in the aMCI adults than in the control adults (P<0.01) while there were no significant differences in MMN amplitude between two groups(P＞0.05). The MMN latency was found to be a sensitive and specific biomarker of aMCI.http://journal.frontiersin.org/Journal/10.3389/fnagi.2015.00022/fullbiomarkersAlzheimer’s diseaseEvent-related potentialsmismatch negativityamnestic mild cognitive impairment |
| spellingShingle | Li li Ji Yuan yuan Zhang Lane eZhang Bing eHe Guo Hua Lu Mismatch negativity (MMN) latency as a biomarker of amnestic mild cognitive impairment in Chinese rural elders Frontiers in Aging Neuroscience biomarkers Alzheimer’s disease Event-related potentials mismatch negativity amnestic mild cognitive impairment |
| title | Mismatch negativity (MMN) latency as a biomarker of amnestic mild cognitive impairment in Chinese rural elders |
| title_full | Mismatch negativity (MMN) latency as a biomarker of amnestic mild cognitive impairment in Chinese rural elders |
| title_fullStr | Mismatch negativity (MMN) latency as a biomarker of amnestic mild cognitive impairment in Chinese rural elders |
| title_full_unstemmed | Mismatch negativity (MMN) latency as a biomarker of amnestic mild cognitive impairment in Chinese rural elders |
| title_short | Mismatch negativity (MMN) latency as a biomarker of amnestic mild cognitive impairment in Chinese rural elders |
| title_sort | mismatch negativity mmn latency as a biomarker of amnestic mild cognitive impairment in chinese rural elders |
| topic | biomarkers Alzheimer’s disease Event-related potentials mismatch negativity amnestic mild cognitive impairment |
| url | http://journal.frontiersin.org/Journal/10.3389/fnagi.2015.00022/full |
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