Ten-year outcomes of uveal melanoma based on The Cancer Genome Atlas (TCGA) classification in 1001 cases
Purpose: To understand the prognostic value of The Cancer Genome Atlas (TCGA) for uveal melanoma metastasis, using a simplified 4-category classification, based on tumor DNA. Methods: A retrospective cohort study of 1001 eyes with uveal melanoma at a single center, categorized according to TCGA as G...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2021-01-01
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| Series: | Indian Journal of Ophthalmology |
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| Online Access: | http://www.ijo.in/article.asp?issn=0301-4738;year=2021;volume=69;issue=7;spage=1839;epage=1845;aulast=Shields |
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| author | Carol L Shields Eileen L Mayro Zeynep Bas Philip W Dockery Antonio Yaghy Sara E Lally Arupa Ganguly Jerry A Shields |
| author_facet | Carol L Shields Eileen L Mayro Zeynep Bas Philip W Dockery Antonio Yaghy Sara E Lally Arupa Ganguly Jerry A Shields |
| author_sort | Carol L Shields |
| collection | DOAJ |
| description | Purpose: To understand the prognostic value of The Cancer Genome Atlas (TCGA) for uveal melanoma metastasis, using a simplified 4-category classification, based on tumor DNA. Methods: A retrospective cohort study of 1001 eyes with uveal melanoma at a single center, categorized according to TCGA as Group A, B, C, or D (by fine-needle aspiration biopsy for DNA analysis), and treated with standard methods, was studied for melanoma-related metastasis at 5 and 10 years. Results: Of 1001 eyes with uveal melanoma, the TCGA categories included Group A (n = 486, 49%), B (n = 141, 14%), C (n = 260, 26%), and D (n = 114, 11%). By comparison, increasing category (A vs. B vs. C vs. D) was associated with features of older age at presentation (56.8 vs. 52.8 vs. 61.1 vs. 63.5 years, P < 0.001), less often visual acuity of 20/20–20/50 (80% vs. 67% vs. 70% vs. 65%, P = 0.001), tumor location further from the optic disc (P < 0.001) and foveola (P < 0.001), and greater median tumor basal diameter (10.0 vs. 13.0 vs. 14.0 vs. 16.0 mm, P < 0.001) and tumor thickness (3.5 vs. 5.2 vs. 6.0 vs. 7.1 mm, P < 0.001). The Kaplan–Meier (5-year/10-year) rate of metastasis was 4%/6% for Group A, 12%/20% for Group B, 33%/49% for Group C, and 60%/not available for Group D. Conclusion: A simplified 4-category classification of uveal melanoma using TCGA, based on tumor DNA, is highly predictive of risk for metastatic disease. |
| first_indexed | 2024-12-16T14:29:57Z |
| format | Article |
| id | doaj.art-c85af9b60a6d4180903bb1f78a5a8119 |
| institution | Directory Open Access Journal |
| issn | 0301-4738 1998-3689 |
| language | English |
| last_indexed | 2024-12-16T14:29:57Z |
| publishDate | 2021-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
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| series | Indian Journal of Ophthalmology |
| spelling | doaj.art-c85af9b60a6d4180903bb1f78a5a81192022-12-21T22:28:16ZengWolters Kluwer Medknow PublicationsIndian Journal of Ophthalmology0301-47381998-36892021-01-016971839184510.4103/ijo.IJO_313_21Ten-year outcomes of uveal melanoma based on The Cancer Genome Atlas (TCGA) classification in 1001 casesCarol L ShieldsEileen L MayroZeynep BasPhilip W DockeryAntonio YaghySara E LallyArupa GangulyJerry A ShieldsPurpose: To understand the prognostic value of The Cancer Genome Atlas (TCGA) for uveal melanoma metastasis, using a simplified 4-category classification, based on tumor DNA. Methods: A retrospective cohort study of 1001 eyes with uveal melanoma at a single center, categorized according to TCGA as Group A, B, C, or D (by fine-needle aspiration biopsy for DNA analysis), and treated with standard methods, was studied for melanoma-related metastasis at 5 and 10 years. Results: Of 1001 eyes with uveal melanoma, the TCGA categories included Group A (n = 486, 49%), B (n = 141, 14%), C (n = 260, 26%), and D (n = 114, 11%). By comparison, increasing category (A vs. B vs. C vs. D) was associated with features of older age at presentation (56.8 vs. 52.8 vs. 61.1 vs. 63.5 years, P < 0.001), less often visual acuity of 20/20–20/50 (80% vs. 67% vs. 70% vs. 65%, P = 0.001), tumor location further from the optic disc (P < 0.001) and foveola (P < 0.001), and greater median tumor basal diameter (10.0 vs. 13.0 vs. 14.0 vs. 16.0 mm, P < 0.001) and tumor thickness (3.5 vs. 5.2 vs. 6.0 vs. 7.1 mm, P < 0.001). The Kaplan–Meier (5-year/10-year) rate of metastasis was 4%/6% for Group A, 12%/20% for Group B, 33%/49% for Group C, and 60%/not available for Group D. Conclusion: A simplified 4-category classification of uveal melanoma using TCGA, based on tumor DNA, is highly predictive of risk for metastatic disease.http://www.ijo.in/article.asp?issn=0301-4738;year=2021;volume=69;issue=7;spage=1839;epage=1845;aulast=Shieldschoroidciliary bodycytogeneticsgeneticsmelanomaoutcomestcgathe cancer genome atlasuvea |
| spellingShingle | Carol L Shields Eileen L Mayro Zeynep Bas Philip W Dockery Antonio Yaghy Sara E Lally Arupa Ganguly Jerry A Shields Ten-year outcomes of uveal melanoma based on The Cancer Genome Atlas (TCGA) classification in 1001 cases Indian Journal of Ophthalmology choroid ciliary body cytogenetics genetics melanoma outcomes tcga the cancer genome atlas uvea |
| title | Ten-year outcomes of uveal melanoma based on The Cancer Genome Atlas (TCGA) classification in 1001 cases |
| title_full | Ten-year outcomes of uveal melanoma based on The Cancer Genome Atlas (TCGA) classification in 1001 cases |
| title_fullStr | Ten-year outcomes of uveal melanoma based on The Cancer Genome Atlas (TCGA) classification in 1001 cases |
| title_full_unstemmed | Ten-year outcomes of uveal melanoma based on The Cancer Genome Atlas (TCGA) classification in 1001 cases |
| title_short | Ten-year outcomes of uveal melanoma based on The Cancer Genome Atlas (TCGA) classification in 1001 cases |
| title_sort | ten year outcomes of uveal melanoma based on the cancer genome atlas tcga classification in 1001 cases |
| topic | choroid ciliary body cytogenetics genetics melanoma outcomes tcga the cancer genome atlas uvea |
| url | http://www.ijo.in/article.asp?issn=0301-4738;year=2021;volume=69;issue=7;spage=1839;epage=1845;aulast=Shields |
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