Therapeutic advances in overcoming intrauterine growth restriction induced metabolic syndrome
Intrauterine growth restriction (IUGR) remains a great public health challenge as it affects neonatal survival and influences their normal biological development and metabolism. Several clinical researches have revealed the occurrence of metabolic syndrome, such as insulin resistance, obesity, type...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-01-01
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| Series: | Frontiers in Pediatrics |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2022.1040742/full |
| _version_ | 1797955996476243968 |
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| author | Alpha Kalonda Mutamba Xiaori He Tao Wang |
| author_facet | Alpha Kalonda Mutamba Xiaori He Tao Wang |
| author_sort | Alpha Kalonda Mutamba |
| collection | DOAJ |
| description | Intrauterine growth restriction (IUGR) remains a great public health challenge as it affects neonatal survival and influences their normal biological development and metabolism. Several clinical researches have revealed the occurrence of metabolic syndrome, such as insulin resistance, obesity, type 2 diabetes mellitus, oxidative stress, dyslipidemia, as direct results of IUGR. Therefore, it is essential to understand its underlying mechanism, impact and develop effective therapies. The purpose of this work is to review the current knowledge on IUGR induced metabolic syndrome and relevant therapies. Here in, we elaborate on the characteristics and causes of IUGR by pointing out recent research findings. Furthermore, we discuss the impact of IUGR on different organs of the body, followed by preclinical studies on IUGR using suitable animal models. Additionally, various metabolic disorders with their genetic implications, such as insulin resistance, type 2 diabetes mellitus, dyslipidemia, obesity are detailed. Finally, the current therapeutic options used in the treatment of IUGR are summarized with some prospective therapies highlighted. |
| first_indexed | 2024-04-10T23:43:02Z |
| format | Article |
| id | doaj.art-c85b517873034a158bc90cb5dfca57c4 |
| institution | Directory Open Access Journal |
| issn | 2296-2360 |
| language | English |
| last_indexed | 2024-04-10T23:43:02Z |
| publishDate | 2023-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj.art-c85b517873034a158bc90cb5dfca57c42023-01-11T06:20:02ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602023-01-011010.3389/fped.2022.10407421040742Therapeutic advances in overcoming intrauterine growth restriction induced metabolic syndromeAlpha Kalonda Mutamba0Xiaori He1Tao Wang2Department of Pediatrics, Neonatology, The Second Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Pediatrics, Neonatology, The Second Xiangya Hospital, Central South University, Changsha, ChinaLaboratory of Neonatal Disease, Institute of Pediatrics, Central South University, Changsha, ChinaIntrauterine growth restriction (IUGR) remains a great public health challenge as it affects neonatal survival and influences their normal biological development and metabolism. Several clinical researches have revealed the occurrence of metabolic syndrome, such as insulin resistance, obesity, type 2 diabetes mellitus, oxidative stress, dyslipidemia, as direct results of IUGR. Therefore, it is essential to understand its underlying mechanism, impact and develop effective therapies. The purpose of this work is to review the current knowledge on IUGR induced metabolic syndrome and relevant therapies. Here in, we elaborate on the characteristics and causes of IUGR by pointing out recent research findings. Furthermore, we discuss the impact of IUGR on different organs of the body, followed by preclinical studies on IUGR using suitable animal models. Additionally, various metabolic disorders with their genetic implications, such as insulin resistance, type 2 diabetes mellitus, dyslipidemia, obesity are detailed. Finally, the current therapeutic options used in the treatment of IUGR are summarized with some prospective therapies highlighted.https://www.frontiersin.org/articles/10.3389/fped.2022.1040742/fullsmall gestational age (SGA)lipid metabolisminsulin resistancetype 2 diabetesintrauterine growth restriction |
| spellingShingle | Alpha Kalonda Mutamba Xiaori He Tao Wang Therapeutic advances in overcoming intrauterine growth restriction induced metabolic syndrome Frontiers in Pediatrics small gestational age (SGA) lipid metabolism insulin resistance type 2 diabetes intrauterine growth restriction |
| title | Therapeutic advances in overcoming intrauterine growth restriction induced metabolic syndrome |
| title_full | Therapeutic advances in overcoming intrauterine growth restriction induced metabolic syndrome |
| title_fullStr | Therapeutic advances in overcoming intrauterine growth restriction induced metabolic syndrome |
| title_full_unstemmed | Therapeutic advances in overcoming intrauterine growth restriction induced metabolic syndrome |
| title_short | Therapeutic advances in overcoming intrauterine growth restriction induced metabolic syndrome |
| title_sort | therapeutic advances in overcoming intrauterine growth restriction induced metabolic syndrome |
| topic | small gestational age (SGA) lipid metabolism insulin resistance type 2 diabetes intrauterine growth restriction |
| url | https://www.frontiersin.org/articles/10.3389/fped.2022.1040742/full |
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