The role and metabolic functions of the branched-chain amino acids: a review
In recent years, a number of new functions of branched-chain amino acids (BCAA) - leucine, valine and isoleucine - have been revealed in various states of the body in animals and humans. BCAA are involved in the regulation of the metabolism of not only proteins, but also lipids and carbohydrates, ma...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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EDP Sciences
2022-01-01
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| Series: | E3S Web of Conferences |
| Online Access: | https://www.e3s-conferences.org/articles/e3sconf/pdf/2022/30/e3sconf_interagromash2022_03054.pdf |
| _version_ | 1797951188544520192 |
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| author | Obvintseva Olga Erimbetov Kenes Mikhailov Vitaly Sofronova Olga Polyakova Lyudmila |
| author_facet | Obvintseva Olga Erimbetov Kenes Mikhailov Vitaly Sofronova Olga Polyakova Lyudmila |
| author_sort | Obvintseva Olga |
| collection | DOAJ |
| description | In recent years, a number of new functions of branched-chain amino acids (BCAA) - leucine, valine and isoleucine - have been revealed in various states of the body in animals and humans. BCAA are involved in the regulation of the metabolism of not only proteins, but also lipids and carbohydrates, maintain the health of the mammary glands and intestines, and help in early implantation and development of embryos. BCAA increase protein synthesis and are currently considered as feed additives to improve meat productivity in pigs. New aspects of metabolic and regulatory functions of BCAA include a number of regularities: 1) insufficient or excessive levels of them in the diet enhances lipolysis; 2) BCAA, especially isoleucine, play an important role in glucose utilization by activating glucose transporters in the intestines and muscles; 3) BCAA enhance the development of the intestine, the transport of amino acids and the production of mucin; 4) BCAA are involved in the regulation of innate and adaptive immune responses. In the near future, the use of high-performance functional genomics, metabolomics, and proteomics will make it possible to more fully reveal the functions of BCAA in gene expression, protein synthesis, and metabolism regulation. |
| first_indexed | 2024-04-10T22:26:40Z |
| format | Article |
| id | doaj.art-c85cb6138b434b1ab7a6655010f05500 |
| institution | Directory Open Access Journal |
| issn | 2267-1242 |
| language | English |
| last_indexed | 2024-04-10T22:26:40Z |
| publishDate | 2022-01-01 |
| publisher | EDP Sciences |
| record_format | Article |
| series | E3S Web of Conferences |
| spelling | doaj.art-c85cb6138b434b1ab7a6655010f055002023-01-17T09:14:14ZengEDP SciencesE3S Web of Conferences2267-12422022-01-013630305410.1051/e3sconf/202236303054e3sconf_interagromash2022_03054The role and metabolic functions of the branched-chain amino acids: a reviewObvintseva Olga0Erimbetov Kenes1Mikhailov Vitaly2Sofronova Olga3Polyakova Lyudmila4Russian Research Institute of Animal Physiology, Biochemistry, and Nutrition-Branch of the L.K. Ernst Federal Research Centre for Animal HusbandryScientific Research Technological Center "Preventive Information Medicine"Tambov State UniversityRussian Research Institute of Animal Physiology, Biochemistry, and Nutrition-Branch of the L.K. Ernst Federal Research Centre for Animal HusbandryRussian Research Institute of Animal Physiology, Biochemistry, and Nutrition-Branch of the L.K. Ernst Federal Research Centre for Animal HusbandryIn recent years, a number of new functions of branched-chain amino acids (BCAA) - leucine, valine and isoleucine - have been revealed in various states of the body in animals and humans. BCAA are involved in the regulation of the metabolism of not only proteins, but also lipids and carbohydrates, maintain the health of the mammary glands and intestines, and help in early implantation and development of embryos. BCAA increase protein synthesis and are currently considered as feed additives to improve meat productivity in pigs. New aspects of metabolic and regulatory functions of BCAA include a number of regularities: 1) insufficient or excessive levels of them in the diet enhances lipolysis; 2) BCAA, especially isoleucine, play an important role in glucose utilization by activating glucose transporters in the intestines and muscles; 3) BCAA enhance the development of the intestine, the transport of amino acids and the production of mucin; 4) BCAA are involved in the regulation of innate and adaptive immune responses. In the near future, the use of high-performance functional genomics, metabolomics, and proteomics will make it possible to more fully reveal the functions of BCAA in gene expression, protein synthesis, and metabolism regulation.https://www.e3s-conferences.org/articles/e3sconf/pdf/2022/30/e3sconf_interagromash2022_03054.pdf |
| spellingShingle | Obvintseva Olga Erimbetov Kenes Mikhailov Vitaly Sofronova Olga Polyakova Lyudmila The role and metabolic functions of the branched-chain amino acids: a review E3S Web of Conferences |
| title | The role and metabolic functions of the branched-chain amino acids: a review |
| title_full | The role and metabolic functions of the branched-chain amino acids: a review |
| title_fullStr | The role and metabolic functions of the branched-chain amino acids: a review |
| title_full_unstemmed | The role and metabolic functions of the branched-chain amino acids: a review |
| title_short | The role and metabolic functions of the branched-chain amino acids: a review |
| title_sort | role and metabolic functions of the branched chain amino acids a review |
| url | https://www.e3s-conferences.org/articles/e3sconf/pdf/2022/30/e3sconf_interagromash2022_03054.pdf |
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