Gene expression profiling in white blood cells reveals new insights into the molecular mechanisms of thalidomide in children with inflammatory bowel disease

Gene expression profiling in white blood cells reveals new insights into the molecular mechanisms of thalidomide in children with inflammatory bowel disease

Thalidomide has emerged as an effective immunomodulator in the treatment of pediatric patients with inflammatory bowel disease (IBD) refractory to standard therapies. Cereblon (CRBN), a component of E3 protein ligase complex that mediates ubiquitination and proteasomal degradation of target proteins...

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Bibliographic Details
Main Authors: Letizia Pugnetti, Debora Curci, Carlotta Bidoli, Marco Gerdol, Fulvio Celsi, Sara Renzo, Monica Paci, Sara Lega, Martina Nonnis, Alessandra Maestro, Liza Vecchi Brumatti, Paolo Lionetti, Alberto Pallavicini, Danilo Licastro, Paolo Edomi, Giuliana Decorti, Gabriele Stocco, Marianna Lucafò, Matteo Bramuzzo
Format: Article
Language:English
Published: Elsevier 2023-08-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Thalidomide
Pediatric
Crohn’s disease
Ulcerative colitis
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332223007175

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