Effect of leukocyte-platelet fibrin-rich wound reconstruction followed by full-thickness skin grafting in the treatment of diabetic foot Wagner grade 4 ulcer gangrene (toe area)
This study investigated the effect of L-PRF on promoting full-thickness skin grafting for the treatment of diabetic foot ulcer wounds and attempted to characterize the mechanism. In a retrospective study, we centrifugated 10–20 ml of venous blood at 1006.2 g for 20 min. The fibrin clot between the t...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-01-01
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| Series: | Platelets |
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| Online Access: | http://dx.doi.org/10.1080/09537104.2022.2131752 |
| _version_ | 1797684095235391488 |
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| author | Yuqi Wang Yanyan Wang Xiaotao Wang Yi Zhao Siyuan Ruan Hong Cao |
| author_facet | Yuqi Wang Yanyan Wang Xiaotao Wang Yi Zhao Siyuan Ruan Hong Cao |
| author_sort | Yuqi Wang |
| collection | DOAJ |
| description | This study investigated the effect of L-PRF on promoting full-thickness skin grafting for the treatment of diabetic foot ulcer wounds and attempted to characterize the mechanism. In a retrospective study, we centrifugated 10–20 ml of venous blood at 1006.2 g for 20 min. The fibrin clot between the top oligocellular plasma layer and the bottom erythrocyte layer was extracted and directly used, without compression, to cover the wound after debridement. Patients who received L-PRF before skin grafting underwent surgery earlier than patients in the control group. Skin necrosis occurred in 7 patients (28%) in the L-PRF group and 16 (64%) in the control group. The difference was statistically significant, P < .05. The postoperative infection rate in the control group (56%) was significantly higher than that in the L-PRF group (24%), P < .05. During a mean follow-up of 1 year, ulcer recurrence occurred in 9 patients (36%) in the control group compared with 4 patients (16%) in the L-PRF group, P < .05. The final amputation rate was also higher in the control group (48%) than in the L-PRF group (20%). The difference is statistically significant, P < .05. The Maryland scale score and SF-36 score of the two groups of patients after treatment were significantly better than those before treatment, and the difference was statistically significant (P < .05). The L-PRF group (94.80 ± 4.14) had better foot scores at the last follow-up after treatment than the control group (88.84 ± 5.22) (P < .05). The results showed that L-PRF played a positive role in the treatment of Wagner grade 4 ulcer gangrene with free full-thickness skin grafts. |
| first_indexed | 2024-03-12T00:25:33Z |
| format | Article |
| id | doaj.art-c85d135d3b4542a8b21a8ea83b9c9561 |
| institution | Directory Open Access Journal |
| issn | 0953-7104 1369-1635 |
| language | English |
| last_indexed | 2024-03-12T00:25:33Z |
| publishDate | 2023-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Platelets |
| spelling | doaj.art-c85d135d3b4542a8b21a8ea83b9c95612023-09-15T10:38:11ZengTaylor & Francis GroupPlatelets0953-71041369-16352023-01-0134110.1080/09537104.2022.21317522131752Effect of leukocyte-platelet fibrin-rich wound reconstruction followed by full-thickness skin grafting in the treatment of diabetic foot Wagner grade 4 ulcer gangrene (toe area)Yuqi Wang0Yanyan Wang1Xiaotao Wang2Yi Zhao3Siyuan Ruan4Hong Cao5Hubei University of MedicineWuhan UniversityHubei University of MedicineJinzhou Medical University Union Training BaseHubei University of MedicineHubei University of MedicineThis study investigated the effect of L-PRF on promoting full-thickness skin grafting for the treatment of diabetic foot ulcer wounds and attempted to characterize the mechanism. In a retrospective study, we centrifugated 10–20 ml of venous blood at 1006.2 g for 20 min. The fibrin clot between the top oligocellular plasma layer and the bottom erythrocyte layer was extracted and directly used, without compression, to cover the wound after debridement. Patients who received L-PRF before skin grafting underwent surgery earlier than patients in the control group. Skin necrosis occurred in 7 patients (28%) in the L-PRF group and 16 (64%) in the control group. The difference was statistically significant, P < .05. The postoperative infection rate in the control group (56%) was significantly higher than that in the L-PRF group (24%), P < .05. During a mean follow-up of 1 year, ulcer recurrence occurred in 9 patients (36%) in the control group compared with 4 patients (16%) in the L-PRF group, P < .05. The final amputation rate was also higher in the control group (48%) than in the L-PRF group (20%). The difference is statistically significant, P < .05. The Maryland scale score and SF-36 score of the two groups of patients after treatment were significantly better than those before treatment, and the difference was statistically significant (P < .05). The L-PRF group (94.80 ± 4.14) had better foot scores at the last follow-up after treatment than the control group (88.84 ± 5.22) (P < .05). The results showed that L-PRF played a positive role in the treatment of Wagner grade 4 ulcer gangrene with free full-thickness skin grafts.http://dx.doi.org/10.1080/09537104.2022.2131752diabetic footfull thickness skin graftleukocyte-platelet-rich fibrinwound healingwound reconstruction |
| spellingShingle | Yuqi Wang Yanyan Wang Xiaotao Wang Yi Zhao Siyuan Ruan Hong Cao Effect of leukocyte-platelet fibrin-rich wound reconstruction followed by full-thickness skin grafting in the treatment of diabetic foot Wagner grade 4 ulcer gangrene (toe area) Platelets diabetic foot full thickness skin graft leukocyte-platelet-rich fibrin wound healing wound reconstruction |
| title | Effect of leukocyte-platelet fibrin-rich wound reconstruction followed by full-thickness skin grafting in the treatment of diabetic foot Wagner grade 4 ulcer gangrene (toe area) |
| title_full | Effect of leukocyte-platelet fibrin-rich wound reconstruction followed by full-thickness skin grafting in the treatment of diabetic foot Wagner grade 4 ulcer gangrene (toe area) |
| title_fullStr | Effect of leukocyte-platelet fibrin-rich wound reconstruction followed by full-thickness skin grafting in the treatment of diabetic foot Wagner grade 4 ulcer gangrene (toe area) |
| title_full_unstemmed | Effect of leukocyte-platelet fibrin-rich wound reconstruction followed by full-thickness skin grafting in the treatment of diabetic foot Wagner grade 4 ulcer gangrene (toe area) |
| title_short | Effect of leukocyte-platelet fibrin-rich wound reconstruction followed by full-thickness skin grafting in the treatment of diabetic foot Wagner grade 4 ulcer gangrene (toe area) |
| title_sort | effect of leukocyte platelet fibrin rich wound reconstruction followed by full thickness skin grafting in the treatment of diabetic foot wagner grade 4 ulcer gangrene toe area |
| topic | diabetic foot full thickness skin graft leukocyte-platelet-rich fibrin wound healing wound reconstruction |
| url | http://dx.doi.org/10.1080/09537104.2022.2131752 |
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