Prognostic Role of Hypoxia-Inducible Factor-2α Tumor Cell Expression in Cancer Patients: A Meta-Analysis
Hypoxia-inducible factor-2α (HIF-2α) plays an important role in tumor progression and metastasis. A number of studies have evaluated the correlation between HIF-2α overexpression and clinical outcome in cancer patients but yielded inconsistent results. To comprehensively and quantitatively summarize...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-06-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fonc.2018.00224/full |
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| author | Eloy Moreno Roig Ala Yaromina Ruud Houben Arjan J. Groot Ludwig Dubois Marc Vooijs |
| author_facet | Eloy Moreno Roig Ala Yaromina Ruud Houben Arjan J. Groot Ludwig Dubois Marc Vooijs |
| author_sort | Eloy Moreno Roig |
| collection | DOAJ |
| description | Hypoxia-inducible factor-2α (HIF-2α) plays an important role in tumor progression and metastasis. A number of studies have evaluated the correlation between HIF-2α overexpression and clinical outcome in cancer patients but yielded inconsistent results. To comprehensively and quantitatively summarize the evidence on the capability of HIF-2α to predict the prognosis of cancer patients with solid tumors, a meta-analysis was carried out. Renal cell carcinoma (CC-RCC) was separately analyzed due to an alternative mechanism of regulation. Systematic literature searches were performed in PubMed and Embase databases for relevant original articles until February 2018. Forty-nine studies with 6,052 patients were included in this study. The pooled hazard ratios (HRs) with corresponding confidence intervals were calculated to assess the prognostic value of HIF-2α protein expression in tumor cells. The meta-analysis revealed strong significant negative associations between HIF-2α expression and five endpoints: overall survival [HR = 1.69, 95% confidence interval (95% CI) 1.39–2.06], disease-free survival (HR = 1.87, 95% CI 1.2–2.92), disease-specific survival (HR = 1.57, 95% CI 1.06–2.34), metastasis-free survival (HR = 2.67, 95% CI 1.32–5.38), and progression-free survival (HR = 2.18, 95% CI 1.25–3.78). Subgroup analyses revealed similar associations in the majority of tumor sites. Overall, these data demonstrate a negative prognostic role of HIF-2α in patients suffering from different types of solid tumors. |
| first_indexed | 2024-12-21T13:28:15Z |
| format | Article |
| id | doaj.art-c85e4c4e698c4b8f81e6cb06c8e63384 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-21T13:28:15Z |
| publishDate | 2018-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-c85e4c4e698c4b8f81e6cb06c8e633842022-12-21T19:02:23ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2018-06-01810.3389/fonc.2018.00224375325Prognostic Role of Hypoxia-Inducible Factor-2α Tumor Cell Expression in Cancer Patients: A Meta-AnalysisEloy Moreno Roig0Ala Yaromina1Ruud Houben2Arjan J. Groot3Ludwig Dubois4Marc Vooijs5Department of Radiotherapy (MAASTRO)/GROW – School for Developmental Biology and Oncology, Maastricht University, Maastricht, NetherlandsDepartment of Radiotherapy (MAASTRO)/GROW – School for Developmental Biology and Oncology, Maastricht University, Maastricht, NetherlandsDepartment of Radiation Oncology, MAASTRO Clinic, Maastricht, NetherlandsDepartment of Radiotherapy (MAASTRO)/GROW – School for Developmental Biology and Oncology, Maastricht University, Maastricht, NetherlandsDepartment of Radiotherapy (MAASTRO)/GROW – School for Developmental Biology and Oncology, Maastricht University, Maastricht, NetherlandsDepartment of Radiotherapy (MAASTRO)/GROW – School for Developmental Biology and Oncology, Maastricht University, Maastricht, NetherlandsHypoxia-inducible factor-2α (HIF-2α) plays an important role in tumor progression and metastasis. A number of studies have evaluated the correlation between HIF-2α overexpression and clinical outcome in cancer patients but yielded inconsistent results. To comprehensively and quantitatively summarize the evidence on the capability of HIF-2α to predict the prognosis of cancer patients with solid tumors, a meta-analysis was carried out. Renal cell carcinoma (CC-RCC) was separately analyzed due to an alternative mechanism of regulation. Systematic literature searches were performed in PubMed and Embase databases for relevant original articles until February 2018. Forty-nine studies with 6,052 patients were included in this study. The pooled hazard ratios (HRs) with corresponding confidence intervals were calculated to assess the prognostic value of HIF-2α protein expression in tumor cells. The meta-analysis revealed strong significant negative associations between HIF-2α expression and five endpoints: overall survival [HR = 1.69, 95% confidence interval (95% CI) 1.39–2.06], disease-free survival (HR = 1.87, 95% CI 1.2–2.92), disease-specific survival (HR = 1.57, 95% CI 1.06–2.34), metastasis-free survival (HR = 2.67, 95% CI 1.32–5.38), and progression-free survival (HR = 2.18, 95% CI 1.25–3.78). Subgroup analyses revealed similar associations in the majority of tumor sites. Overall, these data demonstrate a negative prognostic role of HIF-2α in patients suffering from different types of solid tumors.https://www.frontiersin.org/article/10.3389/fonc.2018.00224/fullcancerhypoxia-inducible factor-2meta-analysisprognosisendothelial PAS domain protein-1 |
| spellingShingle | Eloy Moreno Roig Ala Yaromina Ruud Houben Arjan J. Groot Ludwig Dubois Marc Vooijs Prognostic Role of Hypoxia-Inducible Factor-2α Tumor Cell Expression in Cancer Patients: A Meta-Analysis Frontiers in Oncology cancer hypoxia-inducible factor-2 meta-analysis prognosis endothelial PAS domain protein-1 |
| title | Prognostic Role of Hypoxia-Inducible Factor-2α Tumor Cell Expression in Cancer Patients: A Meta-Analysis |
| title_full | Prognostic Role of Hypoxia-Inducible Factor-2α Tumor Cell Expression in Cancer Patients: A Meta-Analysis |
| title_fullStr | Prognostic Role of Hypoxia-Inducible Factor-2α Tumor Cell Expression in Cancer Patients: A Meta-Analysis |
| title_full_unstemmed | Prognostic Role of Hypoxia-Inducible Factor-2α Tumor Cell Expression in Cancer Patients: A Meta-Analysis |
| title_short | Prognostic Role of Hypoxia-Inducible Factor-2α Tumor Cell Expression in Cancer Patients: A Meta-Analysis |
| title_sort | prognostic role of hypoxia inducible factor 2α tumor cell expression in cancer patients a meta analysis |
| topic | cancer hypoxia-inducible factor-2 meta-analysis prognosis endothelial PAS domain protein-1 |
| url | https://www.frontiersin.org/article/10.3389/fonc.2018.00224/full |
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