Acute basilar thrombosis: Recanalization following intravenous thrombolysis is dependent on thrombus length.
We investigated whether thrombus length measured in Computed Tomography Angiography (CTA) is predictive of the success rate of intravenous thrombolysis (IVT) in acute basilar occlusion and whether recanalization can be achieved by additional mechanical endovascular thrombectomy.In 51 patients with a...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2018-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC5821367?pdf=render |
| _version_ | 1818584539876818944 |
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| author | Hendrik Janssen Hartmut Brückmann Monika Killer Suzette Heck Grete Buchholz Juergen Lutz |
| author_facet | Hendrik Janssen Hartmut Brückmann Monika Killer Suzette Heck Grete Buchholz Juergen Lutz |
| author_sort | Hendrik Janssen |
| collection | DOAJ |
| description | We investigated whether thrombus length measured in Computed Tomography Angiography (CTA) is predictive of the success rate of intravenous thrombolysis (IVT) in acute basilar occlusion and whether recanalization can be achieved by additional mechanical endovascular thrombectomy.In 51 patients with acute basilar thrombosis thrombus length was measured on CTA images before intravenous thrombolysis (IVT) with rt-PA was started. After 114 minutes on average success of IVT was evaluated either by CTA or DSA. Patients with persistent basilar occlusion and no major brainstem infarction on CT underwent endovascular recanalization.87% of patients had no recanalization of basilar artery after IVT alone. The average thrombus length was 15 mm in patients with persistent basilar occlusion after IVT and 7 mm in patients with recanalization after IVT. Thrombi longer than 13 mm did not resolve after IVT alone and 80% of thrombi shorter than 13 mm did not resolve either. 41 patients were transferred to endovascular recanalization; endovascular therapy was performed successfully in 90% (37 / 41).Recanalization rates in acute basilar occlusion after IVT alone are low and dependent on thrombus length. Additional mechanical endovascular thrombectomy showed to be a very successful recanalization therapy. |
| first_indexed | 2024-12-16T08:22:47Z |
| format | Article |
| id | doaj.art-c85ec5a5175b4d0e99023838725a7692 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-16T08:22:47Z |
| publishDate | 2018-01-01 |
| publisher | Public Library of Science (PLoS) |
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| series | PLoS ONE |
| spelling | doaj.art-c85ec5a5175b4d0e99023838725a76922022-12-21T22:38:04ZengPublic Library of Science (PLoS)PLoS ONE1932-62032018-01-01132e019305110.1371/journal.pone.0193051Acute basilar thrombosis: Recanalization following intravenous thrombolysis is dependent on thrombus length.Hendrik JanssenHartmut BrückmannMonika KillerSuzette HeckGrete BuchholzJuergen LutzWe investigated whether thrombus length measured in Computed Tomography Angiography (CTA) is predictive of the success rate of intravenous thrombolysis (IVT) in acute basilar occlusion and whether recanalization can be achieved by additional mechanical endovascular thrombectomy.In 51 patients with acute basilar thrombosis thrombus length was measured on CTA images before intravenous thrombolysis (IVT) with rt-PA was started. After 114 minutes on average success of IVT was evaluated either by CTA or DSA. Patients with persistent basilar occlusion and no major brainstem infarction on CT underwent endovascular recanalization.87% of patients had no recanalization of basilar artery after IVT alone. The average thrombus length was 15 mm in patients with persistent basilar occlusion after IVT and 7 mm in patients with recanalization after IVT. Thrombi longer than 13 mm did not resolve after IVT alone and 80% of thrombi shorter than 13 mm did not resolve either. 41 patients were transferred to endovascular recanalization; endovascular therapy was performed successfully in 90% (37 / 41).Recanalization rates in acute basilar occlusion after IVT alone are low and dependent on thrombus length. Additional mechanical endovascular thrombectomy showed to be a very successful recanalization therapy.http://europepmc.org/articles/PMC5821367?pdf=render |
| spellingShingle | Hendrik Janssen Hartmut Brückmann Monika Killer Suzette Heck Grete Buchholz Juergen Lutz Acute basilar thrombosis: Recanalization following intravenous thrombolysis is dependent on thrombus length. PLoS ONE |
| title | Acute basilar thrombosis: Recanalization following intravenous thrombolysis is dependent on thrombus length. |
| title_full | Acute basilar thrombosis: Recanalization following intravenous thrombolysis is dependent on thrombus length. |
| title_fullStr | Acute basilar thrombosis: Recanalization following intravenous thrombolysis is dependent on thrombus length. |
| title_full_unstemmed | Acute basilar thrombosis: Recanalization following intravenous thrombolysis is dependent on thrombus length. |
| title_short | Acute basilar thrombosis: Recanalization following intravenous thrombolysis is dependent on thrombus length. |
| title_sort | acute basilar thrombosis recanalization following intravenous thrombolysis is dependent on thrombus length |
| url | http://europepmc.org/articles/PMC5821367?pdf=render |
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