Lipidation of pneumococcal proteins enables activation of human antigen-presenting cells and initiation of an adaptive immune response
Streptococcus pneumoniae remains a significant global threat, with existing vaccines having important limitations such as restricted serotype coverage and high manufacturing costs. Pneumococcal lipoproteins are emerging as promising vaccine candidates due to their surface exposure and conservation a...
Main Authors: | Antje D. Paulikat, Dominik Schwudke, Sven Hammerschmidt, Franziska Voß |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2024-04-01
|
Series: | Frontiers in Immunology |
Subjects: | |
Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1392316/full |
Similar Items
-
Lipidation of Pneumococcal Antigens Leads to Improved Immunogenicity and Protection
by: Franziska Voß, et al.
Published: (2020-06-01) -
Intranasal Vaccination With Lipoproteins Confers Protection Against Pneumococcal Colonisation
by: Franziska Voß, et al.
Published: (2018-10-01) -
Preclinical evaluation of a chemically detoxified pneumolysin as pneumococcal vaccine antigen
by: Philippe Hermand, et al.
Published: (2017-01-01) -
The routine use of the urinary pneumococcal antigen test in hospitalised patients with community acquired pneumonia has limited impact for adjustment of antibiotic treatment
by: Rein Jan Piso, et al.
Published: (2012-09-01) -
A broad-spectrum pneumococcal vaccine induces mucosal immunity and protects against lethal Streptococcus pneumoniae challenge
by: Fang-Feng Chiu, et al.
Published: (2023-12-01)