Effects of Curcumin on Growth Performance, Ruminal Fermentation, Rumen Microbial Protein Synthesis, and Serum Antioxidant Capacity in Housed Growing Lambs
This experiment was conducted to investigate growth performance, ruminal fermentation, rumen microbial protein synthesis, and serum antioxidant capacity with different doses of curcumin (CUR) included in the diet of housed growing lambs. Forty-eight four-month-old Dorper × Thin-tailed Han F<sub&g...
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| Format: | Article |
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MDPI AG
2023-04-01
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| Series: | Animals |
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| Online Access: | https://www.mdpi.com/2076-2615/13/9/1439 |
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| author | Guangyuan Tian Xuanzi Zhang Xiaoyan Hao Jianxin Zhang |
| author_facet | Guangyuan Tian Xuanzi Zhang Xiaoyan Hao Jianxin Zhang |
| author_sort | Guangyuan Tian |
| collection | DOAJ |
| description | This experiment was conducted to investigate growth performance, ruminal fermentation, rumen microbial protein synthesis, and serum antioxidant capacity with different doses of curcumin (CUR) included in the diet of housed growing lambs. Forty-eight four-month-old Dorper × Thin-tailed Han F<sub>1</sub> crossbred male lambs (body weight = 20.89 ± 1.15 kg, age = 120 ± 10 days; mean ± SD) were randomly divided into four groups for a single-factor, completely randomized experiment. Treatments comprised the following: the basal diet supplemented with 0 (Control), 300 mg/kg (300 CUR), 600 mg/kg (600 CUR), or 900 mg/kg (900 CUR) CUR, respectively. The results showed that dietary CUR increased average daily gain (ADG), and the 300 CUR group evidenced the highest value. There were no significant effects on dry matter intake (DMI) and DMI/ADG. Lambs in the 300 CUR group showed higher totals of volatile fatty acids (VFA) and acetate than other groups, while decreased valerate was observed with supplementary CUR. The ruminal pH and ammonia N (NH<sub>3</sub>-N) concentration decreased with increasing CUR, with the greatest effect in the 300 CUR group. The quadratic effects were found in pectinase, carboxymethyl cellulose, and protease, with the greatest value in the 300 CUR group. The microbial populations of total bacteria and <i>Ruminococcus albus</i> also responded quadratically, and the methanogens, protozoan, and <i>Fibrobacter succinogenes</i> populations decreased linearly with increasing CUR. Lambs receiving additional CUR showed increased <i>Prevotella ruminicola</i> population. Microbial protein (MCP) synthesis was promoted by supplementary CUR. As supplementation with CUR increased, the serum activity of total antioxidant capacity (T-AOC), superoxide dismutase (SOD), and glutathione peroxidase (GSH-Px) was enhanced, with the greatest value in the 300 CUR group. In conclusion, dietary CUR improved ruminal fermentation, promoted rumen microbial protein (MCP) synthesis, and enhanced serum antioxidant activity, as well as promoting growth performance in housed growing lambs. |
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| institution | Directory Open Access Journal |
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| language | English |
| last_indexed | 2024-03-11T04:25:31Z |
| publishDate | 2023-04-01 |
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| spelling | doaj.art-c8600c779b8642dba7e88c6927d418ed2023-11-17T22:29:07ZengMDPI AGAnimals2076-26152023-04-01139143910.3390/ani13091439Effects of Curcumin on Growth Performance, Ruminal Fermentation, Rumen Microbial Protein Synthesis, and Serum Antioxidant Capacity in Housed Growing LambsGuangyuan Tian0Xuanzi Zhang1Xiaoyan Hao2Jianxin Zhang3College of Animal Science, Shanxi Agriculture University, Jinzhong 030801, ChinaCollege of Animal Science, Shanxi Agriculture University, Jinzhong 030801, ChinaCollege of Animal Science, Shanxi Agriculture University, Jinzhong 030801, ChinaCollege of Animal Science, Shanxi Agriculture University, Jinzhong 030801, ChinaThis experiment was conducted to investigate growth performance, ruminal fermentation, rumen microbial protein synthesis, and serum antioxidant capacity with different doses of curcumin (CUR) included in the diet of housed growing lambs. Forty-eight four-month-old Dorper × Thin-tailed Han F<sub>1</sub> crossbred male lambs (body weight = 20.89 ± 1.15 kg, age = 120 ± 10 days; mean ± SD) were randomly divided into four groups for a single-factor, completely randomized experiment. Treatments comprised the following: the basal diet supplemented with 0 (Control), 300 mg/kg (300 CUR), 600 mg/kg (600 CUR), or 900 mg/kg (900 CUR) CUR, respectively. The results showed that dietary CUR increased average daily gain (ADG), and the 300 CUR group evidenced the highest value. There were no significant effects on dry matter intake (DMI) and DMI/ADG. Lambs in the 300 CUR group showed higher totals of volatile fatty acids (VFA) and acetate than other groups, while decreased valerate was observed with supplementary CUR. The ruminal pH and ammonia N (NH<sub>3</sub>-N) concentration decreased with increasing CUR, with the greatest effect in the 300 CUR group. The quadratic effects were found in pectinase, carboxymethyl cellulose, and protease, with the greatest value in the 300 CUR group. The microbial populations of total bacteria and <i>Ruminococcus albus</i> also responded quadratically, and the methanogens, protozoan, and <i>Fibrobacter succinogenes</i> populations decreased linearly with increasing CUR. Lambs receiving additional CUR showed increased <i>Prevotella ruminicola</i> population. Microbial protein (MCP) synthesis was promoted by supplementary CUR. As supplementation with CUR increased, the serum activity of total antioxidant capacity (T-AOC), superoxide dismutase (SOD), and glutathione peroxidase (GSH-Px) was enhanced, with the greatest value in the 300 CUR group. In conclusion, dietary CUR improved ruminal fermentation, promoted rumen microbial protein (MCP) synthesis, and enhanced serum antioxidant activity, as well as promoting growth performance in housed growing lambs.https://www.mdpi.com/2076-2615/13/9/1439curcumingrowth performanceruminal fermentationmicrobial proteinantioxidantlambs |
| spellingShingle | Guangyuan Tian Xuanzi Zhang Xiaoyan Hao Jianxin Zhang Effects of Curcumin on Growth Performance, Ruminal Fermentation, Rumen Microbial Protein Synthesis, and Serum Antioxidant Capacity in Housed Growing Lambs Animals curcumin growth performance ruminal fermentation microbial protein antioxidant lambs |
| title | Effects of Curcumin on Growth Performance, Ruminal Fermentation, Rumen Microbial Protein Synthesis, and Serum Antioxidant Capacity in Housed Growing Lambs |
| title_full | Effects of Curcumin on Growth Performance, Ruminal Fermentation, Rumen Microbial Protein Synthesis, and Serum Antioxidant Capacity in Housed Growing Lambs |
| title_fullStr | Effects of Curcumin on Growth Performance, Ruminal Fermentation, Rumen Microbial Protein Synthesis, and Serum Antioxidant Capacity in Housed Growing Lambs |
| title_full_unstemmed | Effects of Curcumin on Growth Performance, Ruminal Fermentation, Rumen Microbial Protein Synthesis, and Serum Antioxidant Capacity in Housed Growing Lambs |
| title_short | Effects of Curcumin on Growth Performance, Ruminal Fermentation, Rumen Microbial Protein Synthesis, and Serum Antioxidant Capacity in Housed Growing Lambs |
| title_sort | effects of curcumin on growth performance ruminal fermentation rumen microbial protein synthesis and serum antioxidant capacity in housed growing lambs |
| topic | curcumin growth performance ruminal fermentation microbial protein antioxidant lambs |
| url | https://www.mdpi.com/2076-2615/13/9/1439 |
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