Efficacy and safety of medical cannabinoids in children with cerebral palsy: a systematic review
ABSTRACT Introduction The increasing popularity of cannabinoids for treating numerous neurological disorders has been reported in various countries. Although it reduces tetrahydrocannabinol psychoactivity, it helps patients tolerate higher doses and complements the anti-spasmodic effects of tetrahy...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Instituto Israelita de Ensino e Pesquisa Albert Einstein
2023-11-01
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| Series: | Einstein (São Paulo) |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082023000100404&tlng=en |
| _version_ | 1797542697276276736 |
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| author | Widya Murni Tungki Pratama Umar Kevin Tandarto Abraham Simatupang Armedy Ronny Hasugian Reza Yuridian Purwoko Sri Idaiani Bella Stevanny Caroline Oktarina Reganedgary Jonlean Tamara Tango Kevin Surya Kusuma Sagita Pratiwi Sugiyono Aditya Putra |
| author_facet | Widya Murni Tungki Pratama Umar Kevin Tandarto Abraham Simatupang Armedy Ronny Hasugian Reza Yuridian Purwoko Sri Idaiani Bella Stevanny Caroline Oktarina Reganedgary Jonlean Tamara Tango Kevin Surya Kusuma Sagita Pratiwi Sugiyono Aditya Putra |
| author_sort | Widya Murni |
| collection | DOAJ |
| description | ABSTRACT Introduction The increasing popularity of cannabinoids for treating numerous neurological disorders has been reported in various countries. Although it reduces tetrahydrocannabinol psychoactivity, it helps patients tolerate higher doses and complements the anti-spasmodic effects of tetrahydrocannabinol. One of the most important potential of cannabinoids are related to its potential to help children with cerebral palsy, a contributor of lifelong disability. Therefore, this systematic review aimed to assess the efficacy and safety of medical cannabinoids in children with cerebral palsy. Methods This review adhered to The Preferred Reporting Items for Systematic Reviews and Meta-analysis 2020 guidelines. Seven databases, namely, Scopus, PubMed, EBSCO Host, ProQuest, Google Scholar, Semantic Scholar, and JSTOR, were used to identify relevant studies. Studies examining pediatric patients with cerebral palsy and reporting the efficacy and safety of medical cannabinoids through clinical trials, observational cross-sectional studies, or cohort designs were included. The outcomes of the studies included the efficacy of medical cannabinoids administered for spasticity, motor components, pain control, sleep difficulties, adverse effects, and seizure control. Results Of 803 identified articles, only three met the inclusion criteria for data synthesis. One study exhibited a moderate risk-of-bias. A total of 133 respondents, mainly from Europe, were investigated. Overall effectiveness and safety were considered good. However, the results are inconsistent, especially regarding spasticity treatment variables. Conclusion The anti-spasticity, anti-inflammatory, and anti-seizure properties of cannabinoids might be beneficial for patients with cerebral palsy, although their effectiveness has not been widely studied. Further studies with larger sample sizes and various ethnicities are warranted. Prospero database registration: (www.crd.york.ac.uk/prospero) under ID CRD42022358383. |
| first_indexed | 2024-03-10T13:34:15Z |
| format | Article |
| id | doaj.art-c8627a413a2c4817b9cf61713305a4f8 |
| institution | Directory Open Access Journal |
| issn | 2317-6385 |
| language | English |
| last_indexed | 2024-03-10T13:34:15Z |
| publishDate | 2023-11-01 |
| publisher | Instituto Israelita de Ensino e Pesquisa Albert Einstein |
| record_format | Article |
| series | Einstein (São Paulo) |
| spelling | doaj.art-c8627a413a2c4817b9cf61713305a4f82023-11-21T07:40:56ZengInstituto Israelita de Ensino e Pesquisa Albert EinsteinEinstein (São Paulo)2317-63852023-11-012110.31744/einstein_journal/2023rw0387Efficacy and safety of medical cannabinoids in children with cerebral palsy: a systematic reviewWidya Murnihttps://orcid.org/0000-0002-1023-6493Tungki Pratama Umarhttps://orcid.org/0000-0001-6975-8096Kevin Tandartohttps://orcid.org/0000-0002-6998-8091Abraham Simatupanghttps://orcid.org/0000-0003-2497-9738Armedy Ronny Hasugianhttps://orcid.org/0000-0002-3255-9218Reza Yuridian Purwokohttps://orcid.org/0000-0003-1183-0942Sri Idaianihttps://orcid.org/0000-0001-9010-9103Bella Stevannyhttps://orcid.org/0000-0002-5135-3012Caroline Oktarinahttps://orcid.org/0000-0003-0494-9486Reganedgary Jonleanhttps://orcid.org/0000-0002-5005-4707Tamara Tangohttps://orcid.org/0000-0002-8340-4259Kevin Surya Kusumahttps://orcid.org/0000-0003-1536-5929Sagita Pratiwi Sugiyonohttps://orcid.org/0000-0002-4273-274XAditya Putrahttps://orcid.org/0000-0003-1294-9259ABSTRACT Introduction The increasing popularity of cannabinoids for treating numerous neurological disorders has been reported in various countries. Although it reduces tetrahydrocannabinol psychoactivity, it helps patients tolerate higher doses and complements the anti-spasmodic effects of tetrahydrocannabinol. One of the most important potential of cannabinoids are related to its potential to help children with cerebral palsy, a contributor of lifelong disability. Therefore, this systematic review aimed to assess the efficacy and safety of medical cannabinoids in children with cerebral palsy. Methods This review adhered to The Preferred Reporting Items for Systematic Reviews and Meta-analysis 2020 guidelines. Seven databases, namely, Scopus, PubMed, EBSCO Host, ProQuest, Google Scholar, Semantic Scholar, and JSTOR, were used to identify relevant studies. Studies examining pediatric patients with cerebral palsy and reporting the efficacy and safety of medical cannabinoids through clinical trials, observational cross-sectional studies, or cohort designs were included. The outcomes of the studies included the efficacy of medical cannabinoids administered for spasticity, motor components, pain control, sleep difficulties, adverse effects, and seizure control. Results Of 803 identified articles, only three met the inclusion criteria for data synthesis. One study exhibited a moderate risk-of-bias. A total of 133 respondents, mainly from Europe, were investigated. Overall effectiveness and safety were considered good. However, the results are inconsistent, especially regarding spasticity treatment variables. Conclusion The anti-spasticity, anti-inflammatory, and anti-seizure properties of cannabinoids might be beneficial for patients with cerebral palsy, although their effectiveness has not been widely studied. Further studies with larger sample sizes and various ethnicities are warranted. Prospero database registration: (www.crd.york.ac.uk/prospero) under ID CRD42022358383.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082023000100404&tlng=enCannabinoidsChildCerebral palsyEfficacySafetyPatient safety |
| spellingShingle | Widya Murni Tungki Pratama Umar Kevin Tandarto Abraham Simatupang Armedy Ronny Hasugian Reza Yuridian Purwoko Sri Idaiani Bella Stevanny Caroline Oktarina Reganedgary Jonlean Tamara Tango Kevin Surya Kusuma Sagita Pratiwi Sugiyono Aditya Putra Efficacy and safety of medical cannabinoids in children with cerebral palsy: a systematic review Einstein (São Paulo) Cannabinoids Child Cerebral palsy Efficacy Safety Patient safety |
| title | Efficacy and safety of medical cannabinoids in children with cerebral palsy: a systematic review |
| title_full | Efficacy and safety of medical cannabinoids in children with cerebral palsy: a systematic review |
| title_fullStr | Efficacy and safety of medical cannabinoids in children with cerebral palsy: a systematic review |
| title_full_unstemmed | Efficacy and safety of medical cannabinoids in children with cerebral palsy: a systematic review |
| title_short | Efficacy and safety of medical cannabinoids in children with cerebral palsy: a systematic review |
| title_sort | efficacy and safety of medical cannabinoids in children with cerebral palsy a systematic review |
| topic | Cannabinoids Child Cerebral palsy Efficacy Safety Patient safety |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082023000100404&tlng=en |
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