Possibilities of long-term effective treatment of idiopathic pulmonary arterial hypertension by replacing sildenafil with riociguat and using sequential combination therapy: case report
Modern pathogenetic therapy of idiopathic pulmonary arterial hypertension (IPAH), a severe life-threatening cardiovascular disease of unknown etiology, leads to a positive clinical effect due to reverse remodeling of the vessels of the microvasculature of the lungs. Highly effective drugs of specifi...
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| Format: | Article |
| Language: | Russian |
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InterMedservice
2022-12-01
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| Series: | Евразийский Кардиологический Журнал |
| Subjects: | |
| Online Access: | https://www.heartj.asia/jour/article/view/6353 |
| _version_ | 1797878970788610048 |
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| author | S. A. Musashaykhova Z. S. Valieva A. K. Osokina I. Z. Korobkova V. V. Gramovich N. M. Danilov T. V. Martynyuk |
| author_facet | S. A. Musashaykhova Z. S. Valieva A. K. Osokina I. Z. Korobkova V. V. Gramovich N. M. Danilov T. V. Martynyuk |
| author_sort | S. A. Musashaykhova |
| collection | DOAJ |
| description | Modern pathogenetic therapy of idiopathic pulmonary arterial hypertension (IPAH), a severe life-threatening cardiovascular disease of unknown etiology, leads to a positive clinical effect due to reverse remodeling of the vessels of the microvasculature of the lungs. Highly effective drugs of specific therapy that act on the main targets of pathogenesis have now been introduced into clinical practice.The presented clinical case of a patient with diagnosed in 2014 IPAH with an initial functional class III according to the WHO classification demonstrates high long-term efficacy and safety of specific therapy based on the use of the soluble guanylate cyclase stimulator riociguat for 5 years after replacing previous therapy with sildenafil with further implementation of the strategy of sequential combination therapy due to the addition of ambrisentan and selexipag. |
| first_indexed | 2024-04-10T02:41:39Z |
| format | Article |
| id | doaj.art-c863d9d7f08d4d9791a8af2cbbb45589 |
| institution | Directory Open Access Journal |
| issn | 2225-1685 2305-0748 |
| language | Russian |
| last_indexed | 2024-04-10T02:41:39Z |
| publishDate | 2022-12-01 |
| publisher | InterMedservice |
| record_format | Article |
| series | Евразийский Кардиологический Журнал |
| spelling | doaj.art-c863d9d7f08d4d9791a8af2cbbb455892023-03-13T07:47:39ZrusInterMedserviceЕвразийский Кардиологический Журнал2225-16852305-07482022-12-0104748110.38109/2225-1685-2022-4-74-816284Possibilities of long-term effective treatment of idiopathic pulmonary arterial hypertension by replacing sildenafil with riociguat and using sequential combination therapy: case reportS. A. Musashaykhova0Z. S. Valieva1A. K. Osokina2I. Z. Korobkova3V. V. Gramovich4N. M. Danilov5T. V. Martynyuk6Научно-исследовательский институт клинической кардиологии имени А.Л. Мясникова, ФГБУ «Национальный медицинский исследовательский центр кардиологии им. акад. Е.И. Чазова» Минздрава РоссииНаучно-исследовательский институт клинической кардиологии имени А.Л. Мясникова, ФГБУ «Национальный медицинский исследовательский центр кардиологии им. акад. Е.И. Чазова» Минздрава РоссииНаучно-исследовательский институт клинической кардиологии имени А.Л. Мясникова, ФГБУ «Национальный медицинский исследовательский центр кардиологии им. акад. Е.И. Чазова» Минздрава РоссииНаучно-исследовательский институт клинической кардиологии имени А.Л. Мясникова, ФГБУ «Национальный медицинский исследовательский центр кардиологии им. акад. Е.И. Чазова» Минздрава России; ФГБОУ дополнительного профессионального образования Российская медицинская академия непрерывного профессионального образования Минздрава РоссииНаучно-исследовательский институт клинической кардиологии имени А.Л. Мясникова, ФГБУ «Национальный медицинский исследовательский центр кардиологии им. акад. Е.И. Чазова» Минздрава РоссииНаучно-исследовательский институт клинической кардиологии имени А.Л. Мясникова, ФГБУ «Национальный медицинский исследовательский центр кардиологии им. акад. Е.И. Чазова» Минздрава РоссииНаучно-исследовательский институт клинической кардиологии имени А.Л. Мясникова, ФГБУ «Национальный медицинский исследовательский центр кардиологии им. акад. Е.И. Чазова» Минздрава России; Российский национальный исследовательский медицинский университет имени Н.И. ПироговаModern pathogenetic therapy of idiopathic pulmonary arterial hypertension (IPAH), a severe life-threatening cardiovascular disease of unknown etiology, leads to a positive clinical effect due to reverse remodeling of the vessels of the microvasculature of the lungs. Highly effective drugs of specific therapy that act on the main targets of pathogenesis have now been introduced into clinical practice.The presented clinical case of a patient with diagnosed in 2014 IPAH with an initial functional class III according to the WHO classification demonstrates high long-term efficacy and safety of specific therapy based on the use of the soluble guanylate cyclase stimulator riociguat for 5 years after replacing previous therapy with sildenafil with further implementation of the strategy of sequential combination therapy due to the addition of ambrisentan and selexipag.https://www.heartj.asia/jour/article/view/6353идиопатическая легочная гипертензияспецифическая терапиясилденафилриоцигуатамбризентанселексипагклинический случай |
| spellingShingle | S. A. Musashaykhova Z. S. Valieva A. K. Osokina I. Z. Korobkova V. V. Gramovich N. M. Danilov T. V. Martynyuk Possibilities of long-term effective treatment of idiopathic pulmonary arterial hypertension by replacing sildenafil with riociguat and using sequential combination therapy: case report Евразийский Кардиологический Журнал идиопатическая легочная гипертензия специфическая терапия силденафил риоцигуат амбризентан селексипаг клинический случай |
| title | Possibilities of long-term effective treatment of idiopathic pulmonary arterial hypertension by replacing sildenafil with riociguat and using sequential combination therapy: case report |
| title_full | Possibilities of long-term effective treatment of idiopathic pulmonary arterial hypertension by replacing sildenafil with riociguat and using sequential combination therapy: case report |
| title_fullStr | Possibilities of long-term effective treatment of idiopathic pulmonary arterial hypertension by replacing sildenafil with riociguat and using sequential combination therapy: case report |
| title_full_unstemmed | Possibilities of long-term effective treatment of idiopathic pulmonary arterial hypertension by replacing sildenafil with riociguat and using sequential combination therapy: case report |
| title_short | Possibilities of long-term effective treatment of idiopathic pulmonary arterial hypertension by replacing sildenafil with riociguat and using sequential combination therapy: case report |
| title_sort | possibilities of long term effective treatment of idiopathic pulmonary arterial hypertension by replacing sildenafil with riociguat and using sequential combination therapy case report |
| topic | идиопатическая легочная гипертензия специфическая терапия силденафил риоцигуат амбризентан селексипаг клинический случай |
| url | https://www.heartj.asia/jour/article/view/6353 |
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