Effect of hypothermic perfusion on phacoemulsification in cataract patients complicated with uveitis: a randomised trial
Abstract Background To evaluate the effectiveness and safety of hypothermic perfusion in the phacoemulsification of cataract caused by uveitis. Methods This was a prospective, single-masked, randomised, controlled clinical trial. One hundred and six patients with uveitis-associated cataract underwen...
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| Format: | Article |
| Language: | English |
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BMC
2020-06-01
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| Series: | BMC Ophthalmology |
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| Online Access: | http://link.springer.com/article/10.1186/s12886-020-01507-9 |
| _version_ | 1819106174045257728 |
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| author | Lu Jiang Wenjuan Wan Yan Xun Liang Xiong Binge Wu Yongguo Xiang Zhouyu Li Lu Zhu Yan Ji Peizeng Yang Ke Hu |
| author_facet | Lu Jiang Wenjuan Wan Yan Xun Liang Xiong Binge Wu Yongguo Xiang Zhouyu Li Lu Zhu Yan Ji Peizeng Yang Ke Hu |
| author_sort | Lu Jiang |
| collection | DOAJ |
| description | Abstract Background To evaluate the effectiveness and safety of hypothermic perfusion in the phacoemulsification of cataract caused by uveitis. Methods This was a prospective, single-masked, randomised, controlled clinical trial. One hundred and six patients with uveitis-associated cataract underwent phacoemulsification with perfusion fluid temperature at 4 °C (treatment group) or 24 °C (control group). Anterior chamber inflammation grade, corneal endothelial cell count, corneal thickness, macular fovea thickness, and intraocular pressure (IOP) were observed on the 1st day and 7th day after operation. Results The aqueous flare score was 0.83 ± 0.76 in the 4 °C group, which was lower than that in the 24 °C group (1.51 ± 1.02, p = 0.006) on the first day after operation. The aqueous cells score was lower in the 4 °C group (0.17 ± 0.38) than that in the 24 °C group (0.62 ± 0.94, p = 0.025). The mean corneal thickness of incision in the 4 °C group (907.66 ± 85.37 μm) was thinner than that in the 24 °C group (963.75 ± 103.81 μm, p = 0.005). Corneal endothelial cells density, macular fovea thickness, or percentage of transiently increased IOP showed no difference between the two groups (p > 0.05). There was no significant difference in all the main outcome parameters between the two groups on the 7th day after operation (p > 0.05). Conclusions Hypothermic perfusion in the phacoemulsification of uveitis-associated cataract is safe, and it can effectively inhibit anterior chamber inflammation and reduce the incisional corneal edema in the early postoperative stage. Trial registration The study was registered with the Chinese Clinical Trial Registry. ( http://www.chictr.org.cn/ , Registration Number: ChiCTR1800016145 ). |
| first_indexed | 2024-12-22T02:33:56Z |
| format | Article |
| id | doaj.art-c8648683185a42dcbb26706b8067208e |
| institution | Directory Open Access Journal |
| issn | 1471-2415 |
| language | English |
| last_indexed | 2024-12-22T02:33:56Z |
| publishDate | 2020-06-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Ophthalmology |
| spelling | doaj.art-c8648683185a42dcbb26706b8067208e2022-12-21T18:41:49ZengBMCBMC Ophthalmology1471-24152020-06-012011710.1186/s12886-020-01507-9Effect of hypothermic perfusion on phacoemulsification in cataract patients complicated with uveitis: a randomised trialLu Jiang0Wenjuan Wan1Yan Xun2Liang Xiong3Binge Wu4Yongguo Xiang5Zhouyu Li6Lu Zhu7Yan Ji8Peizeng Yang9Ke Hu10Chongqing Medical UniversityThe First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Ophthalmology and Chongqing Eye InstituteChongqing Medical UniversityChongqing Medical UniversityThe Second affiliated hospital of Baotou medical collegeChongqing Medical UniversityChongqing Medical UniversityChongqing Medical UniversityThe First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Ophthalmology and Chongqing Eye InstituteThe First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Ophthalmology and Chongqing Eye InstituteChongqing Medical UniversityAbstract Background To evaluate the effectiveness and safety of hypothermic perfusion in the phacoemulsification of cataract caused by uveitis. Methods This was a prospective, single-masked, randomised, controlled clinical trial. One hundred and six patients with uveitis-associated cataract underwent phacoemulsification with perfusion fluid temperature at 4 °C (treatment group) or 24 °C (control group). Anterior chamber inflammation grade, corneal endothelial cell count, corneal thickness, macular fovea thickness, and intraocular pressure (IOP) were observed on the 1st day and 7th day after operation. Results The aqueous flare score was 0.83 ± 0.76 in the 4 °C group, which was lower than that in the 24 °C group (1.51 ± 1.02, p = 0.006) on the first day after operation. The aqueous cells score was lower in the 4 °C group (0.17 ± 0.38) than that in the 24 °C group (0.62 ± 0.94, p = 0.025). The mean corneal thickness of incision in the 4 °C group (907.66 ± 85.37 μm) was thinner than that in the 24 °C group (963.75 ± 103.81 μm, p = 0.005). Corneal endothelial cells density, macular fovea thickness, or percentage of transiently increased IOP showed no difference between the two groups (p > 0.05). There was no significant difference in all the main outcome parameters between the two groups on the 7th day after operation (p > 0.05). Conclusions Hypothermic perfusion in the phacoemulsification of uveitis-associated cataract is safe, and it can effectively inhibit anterior chamber inflammation and reduce the incisional corneal edema in the early postoperative stage. Trial registration The study was registered with the Chinese Clinical Trial Registry. ( http://www.chictr.org.cn/ , Registration Number: ChiCTR1800016145 ).http://link.springer.com/article/10.1186/s12886-020-01507-9HypothermiaUveitisCataractPhacoemulsificationPostoperative inflammation |
| spellingShingle | Lu Jiang Wenjuan Wan Yan Xun Liang Xiong Binge Wu Yongguo Xiang Zhouyu Li Lu Zhu Yan Ji Peizeng Yang Ke Hu Effect of hypothermic perfusion on phacoemulsification in cataract patients complicated with uveitis: a randomised trial BMC Ophthalmology Hypothermia Uveitis Cataract Phacoemulsification Postoperative inflammation |
| title | Effect of hypothermic perfusion on phacoemulsification in cataract patients complicated with uveitis: a randomised trial |
| title_full | Effect of hypothermic perfusion on phacoemulsification in cataract patients complicated with uveitis: a randomised trial |
| title_fullStr | Effect of hypothermic perfusion on phacoemulsification in cataract patients complicated with uveitis: a randomised trial |
| title_full_unstemmed | Effect of hypothermic perfusion on phacoemulsification in cataract patients complicated with uveitis: a randomised trial |
| title_short | Effect of hypothermic perfusion on phacoemulsification in cataract patients complicated with uveitis: a randomised trial |
| title_sort | effect of hypothermic perfusion on phacoemulsification in cataract patients complicated with uveitis a randomised trial |
| topic | Hypothermia Uveitis Cataract Phacoemulsification Postoperative inflammation |
| url | http://link.springer.com/article/10.1186/s12886-020-01507-9 |
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