Impact of herpes zoster and post-herpetic neuralgia on health-related quality of life in Miyun District of Beijing, China: An EQ-5D survey
Background: Herpes zoster (HZ) and post-herpetic neuralgia (PHN) cause considerable morbidity, especially in elderly adults, but the burden is under-recognized in mainland China. Methods: We conducted a case registry and follow-up study of HZ in Miyun District, Beijing from January 1, 2017 through D...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-12-01
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| Series: | Vaccine: X |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590136223001560 |
| _version_ | 1827582024457650176 |
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| author | Dan Zhao Luodan Suo Li Lu Jingbin Pan Xinghui Peng Yanfei Wang Xinghuo Pang |
| author_facet | Dan Zhao Luodan Suo Li Lu Jingbin Pan Xinghui Peng Yanfei Wang Xinghuo Pang |
| author_sort | Dan Zhao |
| collection | DOAJ |
| description | Background: Herpes zoster (HZ) and post-herpetic neuralgia (PHN) cause considerable morbidity, especially in elderly adults, but the burden is under-recognized in mainland China. Methods: We conducted a case registry and follow-up study of HZ in Miyun District, Beijing from January 1, 2017 through December 31, 2018. Registered HZ cases were followed-up for pain to 365 days. The first 50 patients with HZ in each age group (≤14, 15–29, 30–39, 40–49, 50–59, 60– 69, 70–79, ≥80 years) and all those with PHN completed the EuroQoL five dimensions questionnaire (EQ-5D) to evaluate health-related quality of life (HRQoL) in patients with HZ and PHN. Ratings using the EQ-5D dimensions, visual analogue scale (VAS), health utility score (HUS) and quality-adjusted life years (QALYs) lost were compared among age groups. Results: In total, 2008 patients with HZ were followed for a median 22 days (interquartile range[IQR] = 20–90), with an estimated incidence of 4.39 per 1000 person-years. We identified 122 (6.08 %) PHN cases. The median age of patients with PHN (65 years, IQR = 55–71) was older than that of patients with HZ (54 years, IQR = 43–64) (P < 0.001). The median duration of pain was 170 days (IQR = 144–355.5) for PHN and 15 days (IQR = 9–25) for HZ. All 95 patients with PHN and 319 sampled patients with HZ completed the EQ-5D survey. The median QALY loss of HZ increased from 0.004 (IQR = 0.001–0.02) in patients 50–59 years old to 0.02 (IQR = 0.01–0.06) in those ≥ 80 years old (P < 0.01). After weighting for age, the mean QALY loss per HZ case was estimated at 0.02 (standard deviation [SD] 0.04). The mean QALY loss per PHN case was 0.13 years (SD 0.12). Conclusions: HZ and PHN caused a substantial burden, especially among adults aged ≥ 50 years in Miyun District, Beijing, China. Vaccination should be considered to alleviate the burden of this painful disease. |
| first_indexed | 2024-03-08T22:44:40Z |
| format | Article |
| id | doaj.art-c864fbaee9bc4b0ea2933238a347835c |
| institution | Directory Open Access Journal |
| issn | 2590-1362 |
| language | English |
| last_indexed | 2024-03-08T22:44:40Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Vaccine: X |
| spelling | doaj.art-c864fbaee9bc4b0ea2933238a347835c2023-12-17T06:41:39ZengElsevierVaccine: X2590-13622023-12-0115100415Impact of herpes zoster and post-herpetic neuralgia on health-related quality of life in Miyun District of Beijing, China: An EQ-5D surveyDan Zhao0Luodan Suo1Li Lu2Jingbin Pan3Xinghui Peng4Yanfei Wang5Xinghuo Pang6Beijing Center for Disease Prevention and Control, Beijing, ChinaBeijing Center for Disease Prevention and Control, Beijing, ChinaBeijing Center for Disease Prevention and Control, Beijing, China; Corresponding author at: Beijing Center for Disease Prevention and Control, No. 16, Hepingli Middle Street, Dongcheng District, Beijing 100013, China.Beijing Center for Disease Prevention and Control, Beijing, ChinaMiyun District of Beijing Center for Disease Prevention and Control, Beijing, ChinaMiyun District of Beijing Center for Disease Prevention and Control, Beijing, ChinaBeijing Center for Disease Prevention and Control, Beijing, ChinaBackground: Herpes zoster (HZ) and post-herpetic neuralgia (PHN) cause considerable morbidity, especially in elderly adults, but the burden is under-recognized in mainland China. Methods: We conducted a case registry and follow-up study of HZ in Miyun District, Beijing from January 1, 2017 through December 31, 2018. Registered HZ cases were followed-up for pain to 365 days. The first 50 patients with HZ in each age group (≤14, 15–29, 30–39, 40–49, 50–59, 60– 69, 70–79, ≥80 years) and all those with PHN completed the EuroQoL five dimensions questionnaire (EQ-5D) to evaluate health-related quality of life (HRQoL) in patients with HZ and PHN. Ratings using the EQ-5D dimensions, visual analogue scale (VAS), health utility score (HUS) and quality-adjusted life years (QALYs) lost were compared among age groups. Results: In total, 2008 patients with HZ were followed for a median 22 days (interquartile range[IQR] = 20–90), with an estimated incidence of 4.39 per 1000 person-years. We identified 122 (6.08 %) PHN cases. The median age of patients with PHN (65 years, IQR = 55–71) was older than that of patients with HZ (54 years, IQR = 43–64) (P < 0.001). The median duration of pain was 170 days (IQR = 144–355.5) for PHN and 15 days (IQR = 9–25) for HZ. All 95 patients with PHN and 319 sampled patients with HZ completed the EQ-5D survey. The median QALY loss of HZ increased from 0.004 (IQR = 0.001–0.02) in patients 50–59 years old to 0.02 (IQR = 0.01–0.06) in those ≥ 80 years old (P < 0.01). After weighting for age, the mean QALY loss per HZ case was estimated at 0.02 (standard deviation [SD] 0.04). The mean QALY loss per PHN case was 0.13 years (SD 0.12). Conclusions: HZ and PHN caused a substantial burden, especially among adults aged ≥ 50 years in Miyun District, Beijing, China. Vaccination should be considered to alleviate the burden of this painful disease.http://www.sciencedirect.com/science/article/pii/S2590136223001560Herpes zosterPost-herpetic neuralgiaQuality-adjusted life yearsEQ-5D |
| spellingShingle | Dan Zhao Luodan Suo Li Lu Jingbin Pan Xinghui Peng Yanfei Wang Xinghuo Pang Impact of herpes zoster and post-herpetic neuralgia on health-related quality of life in Miyun District of Beijing, China: An EQ-5D survey Vaccine: X Herpes zoster Post-herpetic neuralgia Quality-adjusted life years EQ-5D |
| title | Impact of herpes zoster and post-herpetic neuralgia on health-related quality of life in Miyun District of Beijing, China: An EQ-5D survey |
| title_full | Impact of herpes zoster and post-herpetic neuralgia on health-related quality of life in Miyun District of Beijing, China: An EQ-5D survey |
| title_fullStr | Impact of herpes zoster and post-herpetic neuralgia on health-related quality of life in Miyun District of Beijing, China: An EQ-5D survey |
| title_full_unstemmed | Impact of herpes zoster and post-herpetic neuralgia on health-related quality of life in Miyun District of Beijing, China: An EQ-5D survey |
| title_short | Impact of herpes zoster and post-herpetic neuralgia on health-related quality of life in Miyun District of Beijing, China: An EQ-5D survey |
| title_sort | impact of herpes zoster and post herpetic neuralgia on health related quality of life in miyun district of beijing china an eq 5d survey |
| topic | Herpes zoster Post-herpetic neuralgia Quality-adjusted life years EQ-5D |
| url | http://www.sciencedirect.com/science/article/pii/S2590136223001560 |
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