Possible involvement of self-defense mechanisms in the preferential vulnerability of the striatum in Huntington’s disease

Possible involvement of self-defense mechanisms in the preferential vulnerability of the striatum in Huntington’s disease

HD is caused by a mutation in the huntingtin gene that consists in a CAG repeat expansion translated into an abnormal poly-glutamine (polyQ) tract in the huntingtin (Htt) protein. The most striking neuropathological finding in HD is the atrophy of the striatum. The regional expression of mutant Htt...

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Bibliographic Details
Main Authors: Laetitia eFrancelle, Laurie eGalvan, Emmanuel eBrouillet
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-09-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Cell Death
Striatum
signaling
Huntington
excitotoxicity
markers
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00295/full

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