Oral Malignant Melanoma: A Review of the Literature and case report of Hard Palate Malignant Melanoma
Oral malignant melanoma (OMM) is a rare malignant lesion of the oral mucosa. Most cases arise on the palate or gingiva. We made A Review of the Literature focused on relevant molecular and clinical advancements for the oral melanoma to describe the updated knowledge relating to main diagnostic, cli...
| Main Authors: | , |
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| Format: | Article |
| Language: | Arabic |
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Damascus university
2024-03-01
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| Series: | مجلة جامعة دمشق للعلوم الطبية |
| Subjects: | |
| Online Access: | http://journal.damascusuniversity.edu.sy/index.php/heaj/article/view/8178 |
| _version_ | 1797278453132689408 |
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| author | د. رانيه عثمان د. باسم العرسان الياسين |
| author_facet | د. رانيه عثمان د. باسم العرسان الياسين |
| author_sort | د. رانيه عثمان |
| collection | DOAJ |
| description |
Oral malignant melanoma (OMM) is a rare malignant lesion of the oral mucosa. Most cases arise on the palate or gingiva. We made A Review of the Literature focused on relevant molecular and clinical advancements for the oral melanoma to describe the updated knowledge relating to main diagnostic, clinical, and therapeutic implications .And report a case of malignant melanoma of the hard palate extending to the buccal gingiva in 59-year-old Female patient, Final diagnosis was done based on clinical features and H&E and immunohistochemistry (for human melanoma black (HMB)-45 and S-100 protein)for incisional biopsy. Maxillectomy and bilateral neck lymph nodes curettage was done, after surgery radiotherapy was administered 38.4 Gray (32 doses – 1.2 Rad per dose -twice a week) over a period of 3 months and supportive immunotherapy was done also and there were no signs or symptoms to any recurrence after 12 months follow up period.
Careful clinical examination of patients with unusual focal pigmented lesions in the oral cavity and early detection by histopathological means of pigmented growth and periodic follow-up of patients are essential for a better prognosis of this lethal entity.
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| first_indexed | 2024-03-07T16:04:23Z |
| format | Article |
| id | doaj.art-c86b05ac0a8e46868b8baf25ad15aa0a |
| institution | Directory Open Access Journal |
| issn | 2072-2265 2789-6889 |
| language | Arabic |
| last_indexed | 2024-03-07T16:04:23Z |
| publishDate | 2024-03-01 |
| publisher | Damascus university |
| record_format | Article |
| series | مجلة جامعة دمشق للعلوم الطبية |
| spelling | doaj.art-c86b05ac0a8e46868b8baf25ad15aa0a2024-03-04T17:59:08ZaraDamascus universityمجلة جامعة دمشق للعلوم الطبية2072-22652789-68892024-03-01401Oral Malignant Melanoma: A Review of the Literature and case report of Hard Palate Malignant Melanomaد. رانيه عثمان0د. باسم العرسان الياسين1جامعة دمشقجامعة دمشق Oral malignant melanoma (OMM) is a rare malignant lesion of the oral mucosa. Most cases arise on the palate or gingiva. We made A Review of the Literature focused on relevant molecular and clinical advancements for the oral melanoma to describe the updated knowledge relating to main diagnostic, clinical, and therapeutic implications .And report a case of malignant melanoma of the hard palate extending to the buccal gingiva in 59-year-old Female patient, Final diagnosis was done based on clinical features and H&E and immunohistochemistry (for human melanoma black (HMB)-45 and S-100 protein)for incisional biopsy. Maxillectomy and bilateral neck lymph nodes curettage was done, after surgery radiotherapy was administered 38.4 Gray (32 doses – 1.2 Rad per dose -twice a week) over a period of 3 months and supportive immunotherapy was done also and there were no signs or symptoms to any recurrence after 12 months follow up period. Careful clinical examination of patients with unusual focal pigmented lesions in the oral cavity and early detection by histopathological means of pigmented growth and periodic follow-up of patients are essential for a better prognosis of this lethal entity. http://journal.damascusuniversity.edu.sy/index.php/heaj/article/view/8178Oral Malignant MelanomaHard Palate(Hmb)-45 |
| spellingShingle | د. رانيه عثمان د. باسم العرسان الياسين Oral Malignant Melanoma: A Review of the Literature and case report of Hard Palate Malignant Melanoma مجلة جامعة دمشق للعلوم الطبية Oral Malignant Melanoma Hard Palate (Hmb)-45 |
| title | Oral Malignant Melanoma: A Review of the Literature and case report of Hard Palate Malignant Melanoma |
| title_full | Oral Malignant Melanoma: A Review of the Literature and case report of Hard Palate Malignant Melanoma |
| title_fullStr | Oral Malignant Melanoma: A Review of the Literature and case report of Hard Palate Malignant Melanoma |
| title_full_unstemmed | Oral Malignant Melanoma: A Review of the Literature and case report of Hard Palate Malignant Melanoma |
| title_short | Oral Malignant Melanoma: A Review of the Literature and case report of Hard Palate Malignant Melanoma |
| title_sort | oral malignant melanoma a review of the literature and case report of hard palate malignant melanoma |
| topic | Oral Malignant Melanoma Hard Palate (Hmb)-45 |
| url | http://journal.damascusuniversity.edu.sy/index.php/heaj/article/view/8178 |
| work_keys_str_mv | AT drạnyhʿtẖmạn oralmalignantmelanomaareviewoftheliteratureandcasereportofhardpalatemalignantmelanoma AT dbạsmạlʿrsạnạlyạsyn oralmalignantmelanomaareviewoftheliteratureandcasereportofhardpalatemalignantmelanoma |