Kinesin-1, -2, and -3 motors use family-specific mechanochemical strategies to effectively compete with dynein during bidirectional transport

Kinesin-1, -2, and -3 motors use family-specific mechanochemical strategies to effectively compete with dynein during bidirectional transport

Bidirectional cargo transport in neurons requires competing activity of motors from the kinesin-1, -2, and -3 superfamilies against cytoplasmic dynein-1. Previous studies demonstrated that when kinesin-1 attached to dynein-dynactin-BicD2 (DDB) complex, the tethered motors move slowly with a slight p...

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Bibliographic Details
Main Authors: Allison M Gicking, Tzu-Chen Ma, Qingzhou Feng, Rui Jiang, Somayesadat Badieyan, Michael A Cianfrocco, William O Hancock
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-09-01
Series:eLife
Subjects:
bidirectional transport
kinesin
dynein
microtubule
computational modeling
single-molecule
Online Access:https://elifesciences.org/articles/82228

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