Principles underlying the complex dynamics of temperature entrainment by a circadian clock
Summary: Autonomously oscillating circadian clocks resonate with daily environmental (zeitgeber) rhythms to organize physiology around the solar day. Although entrainment properties and mechanisms have been studied widely and in great detail for light-dark cycles, entrainment to daily temperature rh...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2021-11-01
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| Series: | iScience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004221013419 |
| _version_ | 1819006328388976640 |
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| author | Philipp Burt Saskia Grabe Cornelia Madeti Abhishek Upadhyay Martha Merrow Till Roenneberg Hanspeter Herzel Christoph Schmal |
| author_facet | Philipp Burt Saskia Grabe Cornelia Madeti Abhishek Upadhyay Martha Merrow Till Roenneberg Hanspeter Herzel Christoph Schmal |
| author_sort | Philipp Burt |
| collection | DOAJ |
| description | Summary: Autonomously oscillating circadian clocks resonate with daily environmental (zeitgeber) rhythms to organize physiology around the solar day. Although entrainment properties and mechanisms have been studied widely and in great detail for light-dark cycles, entrainment to daily temperature rhythms remains poorly understood despite that they are potent zeitgebers. Here we investigate the entrainment of the chronobiological model organism Neurospora crassa, subject to thermocycles of different periods and fractions of warm versus cold phases, mimicking seasonal variations. Depending on the properties of these thermocycles, regularly entrained rhythms, period-doubling (frequency demultiplication) but also irregular aperiodic behavior occurs. We demonstrate that the complex nonlinear phenomena of experimentally observed entrainment dynamics can be understood by molecular mathematical modeling. |
| first_indexed | 2024-12-21T00:06:56Z |
| format | Article |
| id | doaj.art-c86cdd7fecb0449e9b4cd82d3a3dd946 |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-12-21T00:06:56Z |
| publishDate | 2021-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-c86cdd7fecb0449e9b4cd82d3a3dd9462022-12-21T19:22:26ZengElsevieriScience2589-00422021-11-012411103370Principles underlying the complex dynamics of temperature entrainment by a circadian clockPhilipp Burt0Saskia Grabe1Cornelia Madeti2Abhishek Upadhyay3Martha Merrow4Till Roenneberg5Hanspeter Herzel6Christoph Schmal7Institute for Theoretical Biology, Faculty of Life Sciences, Humboldt-Universität zu Berlin, Unter den Linden 6, 10117 Berlin, Germany; Institute for Theoretical Biology, Charité Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, GermanyInstitute for Theoretical Biology, Faculty of Life Sciences, Humboldt-Universität zu Berlin, Unter den Linden 6, 10117 Berlin, Germany; Institute for Theoretical Biology, Charité Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, GermanyInstitute of Medical Psychology, Faculty of Medicine, LMU Munich, Goethestrasse 31, 80336 Munich, GermanyInstitute for Theoretical Biology, Faculty of Life Sciences, Humboldt-Universität zu Berlin, Unter den Linden 6, 10117 Berlin, Germany; Institute for Theoretical Biology, Charité Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany; Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4058 Basel, SwitzerlandInstitute of Medical Psychology, Faculty of Medicine, LMU Munich, Goethestrasse 31, 80336 Munich, GermanyInstitute of Medical Psychology, Faculty of Medicine, LMU Munich, Goethestrasse 31, 80336 Munich, GermanyInstitute for Theoretical Biology, Faculty of Life Sciences, Humboldt-Universität zu Berlin, Unter den Linden 6, 10117 Berlin, Germany; Institute for Theoretical Biology, Charité Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, GermanyInstitute for Theoretical Biology, Faculty of Life Sciences, Humboldt-Universität zu Berlin, Unter den Linden 6, 10117 Berlin, Germany; Institute for Theoretical Biology, Charité Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany; Corresponding authorSummary: Autonomously oscillating circadian clocks resonate with daily environmental (zeitgeber) rhythms to organize physiology around the solar day. Although entrainment properties and mechanisms have been studied widely and in great detail for light-dark cycles, entrainment to daily temperature rhythms remains poorly understood despite that they are potent zeitgebers. Here we investigate the entrainment of the chronobiological model organism Neurospora crassa, subject to thermocycles of different periods and fractions of warm versus cold phases, mimicking seasonal variations. Depending on the properties of these thermocycles, regularly entrained rhythms, period-doubling (frequency demultiplication) but also irregular aperiodic behavior occurs. We demonstrate that the complex nonlinear phenomena of experimentally observed entrainment dynamics can be understood by molecular mathematical modeling.http://www.sciencedirect.com/science/article/pii/S2589004221013419ChronobiologySystems biologyIn silico biologyPlant biology |
| spellingShingle | Philipp Burt Saskia Grabe Cornelia Madeti Abhishek Upadhyay Martha Merrow Till Roenneberg Hanspeter Herzel Christoph Schmal Principles underlying the complex dynamics of temperature entrainment by a circadian clock iScience Chronobiology Systems biology In silico biology Plant biology |
| title | Principles underlying the complex dynamics of temperature entrainment by a circadian clock |
| title_full | Principles underlying the complex dynamics of temperature entrainment by a circadian clock |
| title_fullStr | Principles underlying the complex dynamics of temperature entrainment by a circadian clock |
| title_full_unstemmed | Principles underlying the complex dynamics of temperature entrainment by a circadian clock |
| title_short | Principles underlying the complex dynamics of temperature entrainment by a circadian clock |
| title_sort | principles underlying the complex dynamics of temperature entrainment by a circadian clock |
| topic | Chronobiology Systems biology In silico biology Plant biology |
| url | http://www.sciencedirect.com/science/article/pii/S2589004221013419 |
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