Infant formula enriched with milk fat globule membrane, long-chain polyunsaturated fatty acids, synbiotics, gangliosides, nucleotides and sialic acid reduces infections during the first 18 months of life: The COGNIS study
Functional nutrients like synbiotics or milk-fat globule membrane (MFGM) affect positively host immunity, modifying intestinal microbioma and reducing early childhood infections. We compared effects of an experimental enriched-infant formula with long chain polyunsaturated fatty acids, MFGM, synbiot...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2021-08-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S175646462100178X |
| _version_ | 1818923100655321088 |
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| author | Florian Herrmann Ana Nieto-Ruiz Natalia Sepúlveda-Valbuena M. Teresa Miranda Estefanía Diéguez Jesús Jiménez Roser De-Castellar María García-Ricobaraza José Antonio García-Santos Mercedes G. Bermúdez Cristina Campoy |
| author_facet | Florian Herrmann Ana Nieto-Ruiz Natalia Sepúlveda-Valbuena M. Teresa Miranda Estefanía Diéguez Jesús Jiménez Roser De-Castellar María García-Ricobaraza José Antonio García-Santos Mercedes G. Bermúdez Cristina Campoy |
| author_sort | Florian Herrmann |
| collection | DOAJ |
| description | Functional nutrients like synbiotics or milk-fat globule membrane (MFGM) affect positively host immunity, modifying intestinal microbioma and reducing early childhood infections. We compared effects of an experimental enriched-infant formula with long chain polyunsaturated fatty acids, MFGM, synbiotics, sialic acid, nucleotides and gangliosides to a standard infant formula and breastfeeding regarding infections incidence and evolution in infants until 18 months of age. 170 healthy infants were enrolled in a RCT to receive either a bioactive functional nutrients enriched infant formula (EF, n = 85) or a standard formula (SF, n = 85). 50 breastfed (BF) infants were also enrolled. At age 12 months, EF group compared to SF and BF groups showed a lower incidence of infectious episodes. Moreover, they also presented less incidence of respiratory tract infections and gastrointestinal infections than SF infants, reducing risk by 30.2% and 32.5%, respectively. Infants fed with an EF seem to have reduced incidence of certain infections at 12 months of age. |
| first_indexed | 2024-12-20T02:04:04Z |
| format | Article |
| id | doaj.art-c86d64607e9b405ea0dda7605779ee62 |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-12-20T02:04:04Z |
| publishDate | 2021-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-c86d64607e9b405ea0dda7605779ee622022-12-21T19:57:15ZengElsevierJournal of Functional Foods1756-46462021-08-0183104529Infant formula enriched with milk fat globule membrane, long-chain polyunsaturated fatty acids, synbiotics, gangliosides, nucleotides and sialic acid reduces infections during the first 18 months of life: The COGNIS studyFlorian Herrmann0Ana Nieto-Ruiz1Natalia Sepúlveda-Valbuena2M. Teresa Miranda3Estefanía Diéguez4Jesús Jiménez5Roser De-Castellar6María García-Ricobaraza7José Antonio García-Santos8Mercedes G. Bermúdez9Cristina Campoy10Department of Paediatrics, School of Medicine. University of Granada. Avda. Investigación 11, 18016 Granada, Spain; Instituto de Investigación Biosanitaria ibs.GRANADA, Health Sciences Technological Park, 18012 Granada, Spain; EURISTIKOS Excellence Centre for Paediatric Research, Biomedical Research Centre, University of Granada, 18016 Granada, SpainDepartment of Paediatrics, School of Medicine. University of Granada. Avda. Investigación 11, 18016 Granada, Spain; Instituto de Investigación Biosanitaria ibs.GRANADA, Health Sciences Technological Park, 18012 Granada, Spain; EURISTIKOS Excellence Centre for Paediatric Research, Biomedical Research Centre, University of Granada, 18016 Granada, Spain; Mind, Brain and Behaviour Research Centre-CIMCYC, University of Granada, 18011 Granada, SpainDepartment of Paediatrics, School of Medicine. University of Granada. Avda. Investigación 11, 18016 Granada, Spain; EURISTIKOS Excellence Centre for Paediatric Research, Biomedical Research Centre, University of Granada, 18016 Granada, Spain; Nutrition and Biochemistry Department, Faculty of Sciences, Pontificia Universidad Javeriana, Bogotá 110231, ColombiaDepartment of Biostatistics, School of Medicine, University of Granada, 18016 Granada, SpainDepartment of Paediatrics, School of Medicine. University of Granada. Avda. Investigación 11, 18016 Granada, Spain; Instituto de Investigación Biosanitaria ibs.GRANADA, Health Sciences Technological Park, 18012 Granada, Spain; EURISTIKOS Excellence Centre for Paediatric Research, Biomedical Research Centre, University of Granada, 18016 Granada, SpainLaboratorios Ordesa, S.L., 08820 Barcelona, SpainLaboratorios Ordesa, S.L., 08820 Barcelona, SpainDepartment of Paediatrics, School of Medicine. University of Granada. Avda. Investigación 11, 18016 Granada, Spain; Instituto de Investigación Biosanitaria ibs.GRANADA, Health Sciences Technological Park, 18012 Granada, Spain; EURISTIKOS Excellence Centre for Paediatric Research, Biomedical Research Centre, University of Granada, 18016 Granada, SpainDepartment of Paediatrics, School of Medicine. University of Granada. Avda. Investigación 11, 18016 Granada, Spain; Instituto de Investigación Biosanitaria ibs.GRANADA, Health Sciences Technological Park, 18012 Granada, Spain; EURISTIKOS Excellence Centre for Paediatric Research, Biomedical Research Centre, University of Granada, 18016 Granada, SpainDepartment of Paediatrics, School of Medicine. University of Granada. Avda. Investigación 11, 18016 Granada, Spain; Instituto de Investigación Biosanitaria ibs.GRANADA, Health Sciences Technological Park, 18012 Granada, Spain; EURISTIKOS Excellence Centre for Paediatric Research, Biomedical Research Centre, University of Granada, 18016 Granada, Spain; Corresponding authors at: Department of Paediatrics, School of Medicine, University of Granada, Avda. de la Investigación, 11-Health Sciences Technological Park, 8016 Granada, SpainDepartment of Paediatrics, School of Medicine. University of Granada. Avda. Investigación 11, 18016 Granada, Spain; Instituto de Investigación Biosanitaria ibs.GRANADA, Health Sciences Technological Park, 18012 Granada, Spain; EURISTIKOS Excellence Centre for Paediatric Research, Biomedical Research Centre, University of Granada, 18016 Granada, Spain; Spanish Network of Biomedical Research in Epidemiology and Public Health (CIBERESP), Granada’s Node, Institute of Health Carlos III, Madrid, Spain; Corresponding authors at: Department of Paediatrics, School of Medicine, University of Granada, Avda. de la Investigación, 11-Health Sciences Technological Park, 8016 Granada, SpainFunctional nutrients like synbiotics or milk-fat globule membrane (MFGM) affect positively host immunity, modifying intestinal microbioma and reducing early childhood infections. We compared effects of an experimental enriched-infant formula with long chain polyunsaturated fatty acids, MFGM, synbiotics, sialic acid, nucleotides and gangliosides to a standard infant formula and breastfeeding regarding infections incidence and evolution in infants until 18 months of age. 170 healthy infants were enrolled in a RCT to receive either a bioactive functional nutrients enriched infant formula (EF, n = 85) or a standard formula (SF, n = 85). 50 breastfed (BF) infants were also enrolled. At age 12 months, EF group compared to SF and BF groups showed a lower incidence of infectious episodes. Moreover, they also presented less incidence of respiratory tract infections and gastrointestinal infections than SF infants, reducing risk by 30.2% and 32.5%, respectively. Infants fed with an EF seem to have reduced incidence of certain infections at 12 months of age.http://www.sciencedirect.com/science/article/pii/S175646462100178XEarly nutritionInfectionInfant formulaSynbioticsMilk fat globule membrane |
| spellingShingle | Florian Herrmann Ana Nieto-Ruiz Natalia Sepúlveda-Valbuena M. Teresa Miranda Estefanía Diéguez Jesús Jiménez Roser De-Castellar María García-Ricobaraza José Antonio García-Santos Mercedes G. Bermúdez Cristina Campoy Infant formula enriched with milk fat globule membrane, long-chain polyunsaturated fatty acids, synbiotics, gangliosides, nucleotides and sialic acid reduces infections during the first 18 months of life: The COGNIS study Journal of Functional Foods Early nutrition Infection Infant formula Synbiotics Milk fat globule membrane |
| title | Infant formula enriched with milk fat globule membrane, long-chain polyunsaturated fatty acids, synbiotics, gangliosides, nucleotides and sialic acid reduces infections during the first 18 months of life: The COGNIS study |
| title_full | Infant formula enriched with milk fat globule membrane, long-chain polyunsaturated fatty acids, synbiotics, gangliosides, nucleotides and sialic acid reduces infections during the first 18 months of life: The COGNIS study |
| title_fullStr | Infant formula enriched with milk fat globule membrane, long-chain polyunsaturated fatty acids, synbiotics, gangliosides, nucleotides and sialic acid reduces infections during the first 18 months of life: The COGNIS study |
| title_full_unstemmed | Infant formula enriched with milk fat globule membrane, long-chain polyunsaturated fatty acids, synbiotics, gangliosides, nucleotides and sialic acid reduces infections during the first 18 months of life: The COGNIS study |
| title_short | Infant formula enriched with milk fat globule membrane, long-chain polyunsaturated fatty acids, synbiotics, gangliosides, nucleotides and sialic acid reduces infections during the first 18 months of life: The COGNIS study |
| title_sort | infant formula enriched with milk fat globule membrane long chain polyunsaturated fatty acids synbiotics gangliosides nucleotides and sialic acid reduces infections during the first 18 months of life the cognis study |
| topic | Early nutrition Infection Infant formula Synbiotics Milk fat globule membrane |
| url | http://www.sciencedirect.com/science/article/pii/S175646462100178X |
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