Optical Coherence Tomography Angiography (OCTA) information content in the diagnosis of type 1 choroidal neovascularization combined with pigment epithelium detachment
Purpose of the study is to determine the reliability of OCT angiography in the diagnosis of type 1 choroidal neovascularization (CNV) in wet age-related macular degeneration depending on the height of pigment epithelium detachment (PED).Material and methods. The study included 82 patients (114 eyes)...
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| Format: | Article |
| Language: | Russian |
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Real Time Ltd
2021-03-01
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| Series: | Российский офтальмологический журнал |
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| Online Access: | https://roj.igb.ru/jour/article/view/580 |
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| author | V. V. Neroev M. V. Ryabina A. P. Sarygina |
| author_facet | V. V. Neroev M. V. Ryabina A. P. Sarygina |
| author_sort | V. V. Neroev |
| collection | DOAJ |
| description | Purpose of the study is to determine the reliability of OCT angiography in the diagnosis of type 1 choroidal neovascularization (CNV) in wet age-related macular degeneration depending on the height of pigment epithelium detachment (PED).Material and methods. The study included 82 patients (114 eyes) with confirmed type 1 CNV, who were examined using spectral OCT and OCTA. The patients were divided into two groups depending on PED height: group 1 consisted of 69 eyes with PED height less than 300 μm, while group 2 (45 eyes) had PED height of more than 300 μm. A separate comparative analysis of the visualization of pathological vessels was made in a group of untreated patients (56 eyes) and a group of patients (58 eyes) treated with angiogenesis inhibitors.Results. In group 1 with a PED height less than 300 μm (167.0 ± 60.4 μm) OCTA detected blood flow along abnormal vessels in 100 % of cases. In group 2 with a PED height above 300 μm (484.7 ± 131.9 μm) CNV vessels were visualized in 24.4 % of eyes. The PED height of patients after intravitreal injections of angiogenesis inhibitors (IVI IA) ranged from 38 to 683 μm (221 ± 133 μm). According to OCTA visualization of type 1 CNV vasculature was noted in 55 eyes (94.8 %). In patients who received no antiangiogenic therapy, with a PED height 59 - 800 μm (238 ± 149 μm) CNV was visualized in 41 % of cases (23 eyes).Conclusion. OCTA showed high reliability in the diagnosis of type 1 CNV with low PED. This method was significantly less informative when the height of the neovascular PED exceeded 300 μm, with the exception of PED after IVI IA. |
| first_indexed | 2024-04-10T02:30:48Z |
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| issn | 2072-0076 2587-5760 |
| language | Russian |
| last_indexed | 2024-04-10T02:30:48Z |
| publishDate | 2021-03-01 |
| publisher | Real Time Ltd |
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| series | Российский офтальмологический журнал |
| spelling | doaj.art-c86e5472a6d84c80ae71fd6a3881c3772023-03-13T07:54:31ZrusReal Time LtdРоссийский офтальмологический журнал2072-00762587-57602021-03-01141424610.21516/2072-0076-2021-14-1-42-46332Optical Coherence Tomography Angiography (OCTA) information content in the diagnosis of type 1 choroidal neovascularization combined with pigment epithelium detachmentV. V. Neroev0M. V. Ryabina1A. P. Sarygina2ФГБУ НМИЦ глазных болезней им. Гельмгольца Минздрава России; ФГБОУ ВО МГМСУ им. А.И. Евдокимова Минздрава РоссииФГБУ НМИЦ глазных болезней им. Гельмгольца Минздрава РоссииФГБУ НМИЦ глазных болезней им. Гельмгольца Минздрава РоссииPurpose of the study is to determine the reliability of OCT angiography in the diagnosis of type 1 choroidal neovascularization (CNV) in wet age-related macular degeneration depending on the height of pigment epithelium detachment (PED).Material and methods. The study included 82 patients (114 eyes) with confirmed type 1 CNV, who were examined using spectral OCT and OCTA. The patients were divided into two groups depending on PED height: group 1 consisted of 69 eyes with PED height less than 300 μm, while group 2 (45 eyes) had PED height of more than 300 μm. A separate comparative analysis of the visualization of pathological vessels was made in a group of untreated patients (56 eyes) and a group of patients (58 eyes) treated with angiogenesis inhibitors.Results. In group 1 with a PED height less than 300 μm (167.0 ± 60.4 μm) OCTA detected blood flow along abnormal vessels in 100 % of cases. In group 2 with a PED height above 300 μm (484.7 ± 131.9 μm) CNV vessels were visualized in 24.4 % of eyes. The PED height of patients after intravitreal injections of angiogenesis inhibitors (IVI IA) ranged from 38 to 683 μm (221 ± 133 μm). According to OCTA visualization of type 1 CNV vasculature was noted in 55 eyes (94.8 %). In patients who received no antiangiogenic therapy, with a PED height 59 - 800 μm (238 ± 149 μm) CNV was visualized in 41 % of cases (23 eyes).Conclusion. OCTA showed high reliability in the diagnosis of type 1 CNV with low PED. This method was significantly less informative when the height of the neovascular PED exceeded 300 μm, with the exception of PED after IVI IA.https://roj.igb.ru/jour/article/view/580age-related macular degenerationchoroidal neovascularization type 1pigment epithelium detachmentoct angiographyanti-vegf therapy |
| spellingShingle | V. V. Neroev M. V. Ryabina A. P. Sarygina Optical Coherence Tomography Angiography (OCTA) information content in the diagnosis of type 1 choroidal neovascularization combined with pigment epithelium detachment Российский офтальмологический журнал age-related macular degeneration choroidal neovascularization type 1 pigment epithelium detachment oct angiography anti-vegf therapy |
| title | Optical Coherence Tomography Angiography (OCTA) information content in the diagnosis of type 1 choroidal neovascularization combined with pigment epithelium detachment |
| title_full | Optical Coherence Tomography Angiography (OCTA) information content in the diagnosis of type 1 choroidal neovascularization combined with pigment epithelium detachment |
| title_fullStr | Optical Coherence Tomography Angiography (OCTA) information content in the diagnosis of type 1 choroidal neovascularization combined with pigment epithelium detachment |
| title_full_unstemmed | Optical Coherence Tomography Angiography (OCTA) information content in the diagnosis of type 1 choroidal neovascularization combined with pigment epithelium detachment |
| title_short | Optical Coherence Tomography Angiography (OCTA) information content in the diagnosis of type 1 choroidal neovascularization combined with pigment epithelium detachment |
| title_sort | optical coherence tomography angiography octa information content in the diagnosis of type 1 choroidal neovascularization combined with pigment epithelium detachment |
| topic | age-related macular degeneration choroidal neovascularization type 1 pigment epithelium detachment oct angiography anti-vegf therapy |
| url | https://roj.igb.ru/jour/article/view/580 |
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